2022
DOI: 10.1038/s41467-022-33249-1
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Transformation of primary sensory cortical representations from layer 4 to layer 2

Abstract: Sensory input arrives from thalamus in cortical layer (L) 4, which outputs predominantly to superficial layers. L4 to L2 thus constitutes one of the earliest cortical feedforward networks. Despite extensive study, the transformation performed by this network remains poorly understood. We use two-photon calcium imaging to record neural activity in L2-4 of primary vibrissal somatosensory cortex (vS1) as mice perform an object localization task with two whiskers. Touch responses sparsen and become more reliable f… Show more

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Cited by 17 publications
(28 citation statements)
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“…We find that broadly tuned neurons -bidirectional single whisker and especially multiwhisker neurons -are more stable than narrowly tuned single whisker neurons. From L4 to L2, representations of whisker touch transition from narrow to broad tuning and from distributed to ensemble based coding 20 . This cross-laminar receptive field broadening is found in many sensory cortices [17][18][19]41 .…”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations
“…We find that broadly tuned neurons -bidirectional single whisker and especially multiwhisker neurons -are more stable than narrowly tuned single whisker neurons. From L4 to L2, representations of whisker touch transition from narrow to broad tuning and from distributed to ensemble based coding 20 . This cross-laminar receptive field broadening is found in many sensory cortices [17][18][19]41 .…”
Section: Discussionmentioning
confidence: 99%
“…Following segmentation, neuropil subtraction and ΔF/F computation were performed. For layer assignment, each neuron was first assigned a depth in reference to a single reference plane taken at the top of the dura 20 . The L1-L2 border was defined at the depth of the most superficially imaged excitatory neuron and the L3-L4 border was found by manually locating a noticeable shift in neuron morphology in conjunction with the emergence of clearly visible septa.…”
Section: Imaging Data Processingmentioning
confidence: 99%
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“…Our findings provide long sought-after evidence for a synaptic depression mechanism at intracortical synapses that generates sensory adaptation and sparsens representations. Given the similarity of cortical structure and observed features of rapid adaptation across sensory areas, this mechanism could be applicable across many stimulus modalities 9,[72][73][74] . Release probability is an inherent property at chemical synapses in the brain 11 ; thus, molecular machinery and neuromodulators that affect Pr can regulate synaptic transmission at a given set of synapses over time (as we've studied here), but could also specialize the dynamics of responses across different brain areas, or even different species.…”
Section: Distinct Time Scales and Perceptual Effects Of Adaptationmentioning
confidence: 99%