Transformation products of amoxicillin and ampicillin after photolysis in aqueous matrices: Identification and kinetics

Arsand, Juliana Bazzan; Hoff, Rodrigo Barcellos; Jank, Louíse; Meirelles, Lucas N.; Díaz˗Cruz, M. Silvia; Pizzolato, Tânia Mara; Barceló, Damià

doi:10.1016/j.scitotenv.2018.06.122

Cited by 49 publications

(21 citation statements)

References 35 publications

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“…Different categories of antibiotics have been detected, mainly including β-lactams, MAs, FQs, TCs, SAs, diaminopyrimidines, and some metabolites (Table 1). Although the consumption of βlactams (penicillins and cephalosporins) is high [2,10,50], in most cases, they are rarely detected in aqueous environments; which may be attributed to their easy hydrolysis and photolysis, as well as effective removals in WWTPs [15,[51][52][53]. According to the surveys [2,5,27], MAs, FQs, TCs, and SAs were the most frequently detected classes of antibiotics in the aquatic environments, which is consistent with the most widely used categories of antibiotics [2,10,50].…”

Section: Groundwater and Drinking Watersupporting

confidence: 63%

Antibiotics: An overview on the environmental occurrence, toxicity, degradation, and removal methods

et al. 2021

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Antibiotics, as antimicrobial drugs, have been widely applied as human and veterinary medicines. Recently, many antibiotics have been detected in the environments due to their mass production, widespread use, but a lack of adequate treatment processes. The environmental occurrence of antibiotics has received worldwide attention due to their potential harm to the ecosystem and human health. Research status of antibiotics in the environment field is presented by bibliometrics. Herein, we provided a comprehensive overview on the following important issues: (1) occurrence of antibiotics in different environmental compartments, such as wastewater, surface water, and soil; (2) toxicity of antibiotics toward non-target organisms, including aquatic and terrestrial organisms; (3) current treatment technologies for the degradation and removal of antibiotics, including adsorption, hydrolysis, photodegradation and oxidation, and biodegradation. It was found that macrolides, fluoroquinolones, tetracyclines, and sulfonamides were most frequently detected in the environment. Compared to surface and groundwaters, wastewater contained a high concentration of antibiotic residues. Both antibiotics and their metabolites exhibited toxicity to non-target organisms, especially aquatic organisms (e.g., algae and fish). Fluoroquinolones, tetracyclines, and sulfonamides can be removed through abiotic process, such as adsorption, photodegradation, and oxidation. Fluoroquinolones and sulfonamides can directly undergo biodegradation. Further studies on the chronic effects of antibiotics at environmentally relevant concentrations on the ecosystem were urgently needed to fully understand the hazards of antibiotics and help the government to establish the permissible limits. Biodegradation is a promising technology; it has numerous advantages such as cost-effectiveness and environmental friendliness.

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Section: Groundwater and Drinking Watersupporting

confidence: 63%

Antibiotics: An overview on the environmental occurrence, toxicity, degradation, and removal methods

et al. 2021

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“…The detection domain studied in this work does not include the concentration values of the maximum levels of ampicillin set by the European Union. It is worthy to note that studies showed that the degradation of ampicillin is almost complete and reaches a maximum after 48 h in rivers [ 46 ]. Therefore, taking into consideration this degradation step, it is of high interest to develop an aptasensor for ampicillin detection in samples with very low antibiotic concentrations.…”

Section: Resultsmentioning

confidence: 99%

MoS2/PPy Nanocomposite as a Transducer for Electrochemical Aptasensor of Ampicillin in River Water

et al. 2021

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We report the design of an electrochemical aptasensor for ampicillin detection, which is an antibiotic widely used in agriculture and considered to be a water contaminant. We studied the transducing potential of nanostructure composed of MoS2 nanosheets and conductive polypyrrole nanoparticles (PPyNPs) cast on a screen-printed electrode. Fine chemistry is developed to build the biosensors entirely based on robust covalent immobilizations of naphthoquinone as a redox marker and the aptamer. The structural and morphological properties of the nanocomposite were studied by SEM, AFM, and FT-IR. High-resolution XPS measurements demonstrated the formation of a binding between the two nanomaterials and energy transfer affording the formation of heterostructure. Cyclic voltammetry and electrochemical impedance spectroscopy were used to analyze their electrocatalytic properties. We demonstrated that the nanocomposite formed with PPyNPs and MoS2 nanosheets has electro-catalytic properties and conductivity leading to a synergetic effect on the electrochemical redox process of the redox marker. Thus, a highly sensitive redox process was obtained that could follow the recognition process between the apatamer and the target. An amperometric variation of the naphthoquinone response was obtained regarding the ampicillin concentration with a limit of detection (LOD) of 10 pg/L (0.28 pM). A high selectivity towards other contaminants was demonstrated with this biosensor and the analysis of real river water samples without any treatment showed good recovery results thanks to the antifouling properties. This biosensor can be considered a promising device for the detection of antibiotics in the environment as a point-of-use system.

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“…In contrast, UV-B H 2 O 2 photolysis led a high AMX removal around 80% after 75 min of simulated sunlight irradiation. Several studies have reported that AMX undergoes photolysis/hydrolysis reactions (Lamm et al 2009;Pérez-Parada et al 2011;Arsand et al 2018). However, these studies reported that although AMX suffered photo-transformations, it was still found after 24 h of simulated sunlight irradiation (Arsand et al 2018).…”

Section: Resultsmentioning

confidence: 99%

Photo-Fenton process at natural conditions of pH, iron, ions, and humic acids for degradation of diuron and amoxicillin

Buitrago

Sanabria

Gutiérrez‐Zapata

et al. 2019

Environ Sci Pollut Res

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Effect of ferric ions at concentrations typically found in natural waters (0.05 to 1.06 mg L −1 ) and low H 2 O 2 concentrations (between 0.5 and 17.9 mg L −1 ) on simulated sunlight-induced (300 W m −2 ) photo-Fenton degradation at initial neutral pH (7.0) of amoxicillin and diuron in Milli-Q water was studied using an rotatable central composite experimental design 2 2 with a central and two axial points. H 2 O 2 concentration was the parameter playing the key role on the degradation of both pollutants. Despite that initial pH was 7.0 in Milli-Q water, this latter decreased rapidly in the first minutes, reaching values of 3.5 and 5.0 for diuron and amoxicillin respectively after 15 min of simulated sunlight irradiation. In contrast, in presence of bicarbonate/carbonate (HCO 3), fluoride (F − ), and humic acids (HAs) at concentrations found often in surface and well waters with ferric ion and H 2 O 2 concentrations of 0.3 and 9.7 and 15.2 mg L −1 respectively, both pollutants exhibited a strong degradation keeping the circumneutral pH. Amoxicillin and diuron degradation byproducts found by HPLC/MS were compatible with HO • and/or CO 3 -• radical attack. Several photo-induced processes such as photo-Fenton (by dissolved ferric-HA complexes), heterogeneous photocatalysis (by colloidal iron), UV-B H 2 O 2 photolysis, irradiated-dissolved organic matter, and their reactions with pollutants would be the main oxidative route responsible of degradations. These findings demonstrated that it could be possible using iron concentrations often found in natural waters to oxidize via photo-Fenton processes among other events, organic pollutants at natural pH conditions.Keywords Circumneutral photo-Fenton . Diuron . Amoxicillin . H 2 O 2 photolysis . Water detoxification . Low iron amounts * Paula Osorio-Vargas

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Transformation products of amoxicillin and ampicillin after photolysis in aqueous matrices: Identification and kinetics

Cited by 49 publications

References 35 publications

Antibiotics: An overview on the environmental occurrence, toxicity, degradation, and removal methods

Antibiotics: An overview on the environmental occurrence, toxicity, degradation, and removal methods

MoS2/PPy Nanocomposite as a Transducer for Electrochemical Aptasensor of Ampicillin in River Water

Photo-Fenton process at natural conditions of pH, iron, ions, and humic acids for degradation of diuron and amoxicillin

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