Transformed rodent cells exhibit increased resistance to the carboxylic ionophores monensin and nigericin

Liteplo, Robert G.

doi:10.1016/0006-291x(91)91442-f

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…Given that monensin has a favorable safety profile and acts effectively at low micromolar concentrations, further investigation of the detailed mechanism underlying its mode of action is warranted. As a carboxylic Na + /H + ionophore, monensin has been noted to exert significant effects on function and activity of the Golgi apparatus and the intracellular trafficking and processing of endocytosis 29 . Earlier studies in fact utilized monensin conjugates or liposomes to deliver therapeutic monoclonal antibodies, immunotoxins, or chemotherapy drugs 30 31 32 33 34 35 .…”

Section: Discussionmentioning

confidence: 99%

Antibiotic monensin synergizes with EGFR inhibitors and oxaliplatin to suppress the proliferation of human ovarian cancer cells

Deng

Zhang

Wang

et al. 2015

Sci Rep

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Ovarian cancer is the most lethal gynecologic malignancy with an overall cure rate of merely 30%. Most patients experience recurrence within 12–24 months of cure and die of progressively chemotherapy-resistant disease. Thus, more effective anti-ovarian cancer therapies are needed. Here, we investigate the possibility of repurposing antibiotic monensin as an anti-ovarian cancer agent. We demonstrate that monensin effectively inhibits cell proliferation, migration and cell cycle progression, and induces apoptosis of human ovarian cancer cells. Monensin suppresses multiple cancer-related pathways including Elk1/SRF, AP1, NFκB and STAT, and reduces EGFR expression in ovarian cancer cells. Monensin acts synergistically with EGFR inhibitors and oxaliplatin to inhibit cell proliferation and induce apoptosis of ovarian cancer cells. Xenograft studies confirm that monensin effectively inhibits tumor growth by suppressing cell proliferation through targeting EGFR signaling. Our results suggest monensin may be repurposed as an anti-ovarian cancer agent although further preclinical and clinical studies are needed.

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Section: Discussionmentioning

confidence: 99%

Antibiotic monensin synergizes with EGFR inhibitors and oxaliplatin to suppress the proliferation of human ovarian cancer cells

Deng

Zhang

Wang

et al. 2015

Sci Rep

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“…For example, the transport of the gp70 glycoprotein to the cell surface and concomitant release of infectious virus has been reported to be inhibited by treatment of Friend murine leukemia virus-infected eveline cells with monensin (33). On the contrary, the rodent fibroblasts transformed with the Kirsten and Moloney murine sarcoma viruses exhibit increased resistance to the growth inhibitory and cytotoxic action of the antibiotic (18).…”

Section: Introductionmentioning

confidence: 99%

In VitroActivity of Biometal(II) Complexes of Monensin Against Virus-Induced Transplantable Animal Tumors

Pantcheva

Alexandrova

Zhivkova

et al. 2013

Biotechnology & Biotechnological Equipment

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Cellular Internalization of Cytolethal Distending Toxin fromHaemophilus ducreyi

et al. 2000

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The chancroid bacterium Haemophilus ducreyi produces a toxin (HdCDT) which is a member of the recently discovered family of cytolethal distending toxins (CDTs). These protein toxins prevent the cyclin-dependent kinase cdc2 from being activated, thus blocking the transition of cells from the G 2 phase into mitosis, with the consequent arrest of intoxicated cells in G 2 . It is not known whether these toxins act by signaling from the cell surface or intracellularly only. Here we report that HdCDT has to undergo at least internalization before being able to act. Cellular intoxication was inhibited (i) by removal of clathrin coats via K ؉ depletion, (ii) by treatment with drugs that inhibit receptor clustering into coated pits, and (iii) in cells genetically manipulated to fail in clathrin-dependent endocytosis. Intoxication was also completely inhibited in cells treated with bafilomycin A1 or nocodazole and in cells incubated at 18°C, i.e., under conditions known to block the fusion of early endosomes with downstream compartments. Moreover, disruption of the Golgi complex by treatment with brefeldin A or ilimaquinone blocked intoxication. In conclusion, our data indicate that HdCDT enters cells via clathrincoated pits and has to be transported via the Golgi complex in order to intoxicate cells. This is the first member of the family of CDTs for which cellular internalization and some details of the pathway have been demonstrated.

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Transformed rodent cells exhibit increased resistance to the carboxylic ionophores monensin and nigericin

Cited by 3 publications

References 12 publications

Antibiotic monensin synergizes with EGFR inhibitors and oxaliplatin to suppress the proliferation of human ovarian cancer cells

Antibiotic monensin synergizes with EGFR inhibitors and oxaliplatin to suppress the proliferation of human ovarian cancer cells

In VitroActivity of Biometal(II) Complexes of Monensin Against Virus-Induced Transplantable Animal Tumors

Cellular Internalization of Cytolethal Distending Toxin fromHaemophilus ducreyi

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