Water treatment, such as disinfection, is an integral stage of its use for human life. The use of plasma technology with high-voltage electric discharge in a liquid for obtaining a bactericidal effect is discussed. It has been experimentally shown that among the factors accompanying a high-voltage electric discharge in a liquid and affecting the viability of bacteria, cavitation is the main one. Simultaneous use of electric discharge in the special cavitation mode and oxidizing agents makes it possible to achieve stable disinfection of water. At the same time, bactericidal doses of the oxidizing agent are reduced by a factor of 10 relative to existing standards, and the energy costs for electric discharge exposure, enhanced by small doses of an oxidizing agent, are reduced by 6 times compared to the costs of disinfection by only an electric discharge.