Transforming growth factor beta 1 and metalloproteinase-9 overexpression in colorectal cancer (CC) and adenoma

Abstract

The increased expression of TGFbeta1, MMP-9 observed in colorectal adenomas seems to be related to the grade of dysplasia. We assume that overexpression of TGFbeta1, MMP-9 represent an early event in colorectal carcinogenesis and may possibly have the prognostic value.

784 Clinical applications of molecular profiling of colorectal cancer

“…These findings confirm previous work by Daniel et al (2007), investigating TGFB1 protein expression by IHC in colorectal cancer. The authors demonstrated than in highgrade dysplastic polyps, than in low-grade dysplastic polyp [521].…”

“…These findings confirm previous work by Daniel et al (2007), investigating TGFB1 protein expression by IHC in colorectal cancer. The authors demonstrated than in highgrade dysplastic polyps, than in low-grade dysplastic polyp [521]. Matsushita et al (1999) found that TGFB receptor mRNA was expressed mainly by normal and adenoma colorectal tissues whereas TGFB1 expressed by cancer [516].…”

“…Matsushita et al (1999) found that TGFB receptors mRNA expressed mainly by normal and adenoma colorectal tissues whereas TGFB1 expressed by cancer [516]. Moreover, Daniel et al (2007), using immunohistochemistry, identified higher TGFB1 protein expression in colorectal cancer, than in high-grade dysplastic polyp, than in lowgrade dysplastic polyp [521]. The significant positive correlation between TGFB1 and its receptors expression levels in both tumour and normal colorectal tissues confirm that their role in colorectal cancer is more complex than a simple legendreceptor feedback.…”

Prognostic Significance of Matrix Metalloproteinase-9 (MMP-9) in Stage II Colorectal Carcinoma

“…MMP-9 expression is also significantly increased in CRC tissues [11]. Overexpression of MMP-9 and elevated serum MMP-9 represents an early event in colorectal carcinogenesis and may be of possible prognostic value [12,13].…”

Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2

“…MMPs are increasingly involved in the breakdown of ECM and suggested to play an important role in the process of tumor invasion and metastasis [20,21]. Over expressions of MMP (2 and 9) have been demonstrated in human colorectal cancers [22,23]. The extracellular signal-regulated kinase (ERK) signaling pathway plays a major role in the control of diverse cellular processes such as proliferation, survival, differentiation and motility.…”