Transforming growth factor-β and fibrosis

TP53INP1 decreases pancreatic cancer cell migration by regulating SPARC expression

“…Interestingly, SPARC was previously associated with the regulation of TGFb (Schiemann et al, 2003). TGFb is a master regulator of wound-healing and fibrosis by inducing the synthesis of several ECM proteins including collagen and FN1 (Verrecchia and Mauviel, 2007). Ample data demonstrate that TGFb induces SPARC expression (Wrana et al, 1991;Ford et al, 1993;Reed et al, 1994).…”

Pulmonary fibrosis: tissue characterization using late-enhanced MRI compared with unenhanced anatomic high-resolution CT

“…Fibroblasts are mesenchymal cells derived from the embryonic mesoderm tissue, and are not terminally differentiated. They can reactivate through several chemical signals that promote proliferation and cellular differentiation to form myofibroblasts with an upregulated rate of matrix production (22). Fibroblast activation plays a vital role in wound healing.…”

Human peritoneal mesothelial cell transformation into myofibroblasts in response to TGF-ß1 in vitro

“…During parenchymal inflammation the HPMCs are exposed to a microenvironment with high levels of cytokines, chemokines and growth factors, including TGF-ß1 (8). TGF-ß1 is considered to be a master switch for the induction of fibrosis by a process of EMT in various organs including the peritoneum (11)(12)(13). During stress/injury HPMCs attain plasticity and lose their polarity and mesothelial markers.…”