Transforming growth factor-β and myostatin signaling in skeletal muscle

Kollias, Helen D.; McDermott, John C.

doi:10.1152/japplphysiol.01091.2007

Cited by 276 publications

(254 citation statements)

References 83 publications

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“…The type I receptor is the center of the signaling as it is essential for signal specificity as well as for signal propagation beyond the plasma membrane. 15,16 Cross-linking studies demonstrated that activin receptor IIB (ACVR2B) is the primary type II receptor for myostatin. 37,38 Blocking the activity of this receptor in mice models leads to dramatic increases in muscle mass, comparable with those seen in myostatin knock out mice.…”

Section: Discussionmentioning

confidence: 99%

“…ACVR1B got the highest ranking because of its high significance in both the combined linkage and association approach (Figure 2) and the familybased association analyses (Figure 3), and because the ACVR1B protein has a role in the molecular TGFb pathway regulating the signaling of myostatin, a negative regulator of skeletal muscle mass. 15,16 Even though it ranked lower, INHBC was also included for follow-up because it is a part of the same superfamily of proteins as ACVR1B.…”

Section: Fine Mapping Stagementioning

confidence: 99%

“…Our observations fit with available physiological data that demonstrate a potential role for ACVR1B in the regulation of muscle mass, as it is part of the transforming growth factor b (TGFb) pathway regulating myostatin -a negative regulator of muscle mass -signaling. 15,16 …”

Section: Introductionmentioning

confidence: 99%

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Comprehensive fine mapping of chr12q12-14 and follow-up replication identify activin receptor 1B (ACVR1B) as a muscle strength gene

et al. 2010

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Muscle strength is important in functional activities of daily living and the prevention of common pathologies. We describe the two-staged fine mapping of a previously identified linkage peak for knee strength on chr12q12-14. First, 209 tagSNPs in/around 74 prioritized genes were genotyped in 500 Caucasian brothers from the Leuven Genes for Muscular Strength study (LGfMS). Combined linkage and family-based association analyses identified activin receptor 1B (ACVR1B) and inhibin b C (INHBC), part of the transforming growth factor b pathway regulating myostatin -a negative regulator of muscle mass -signaling, for follow-up. Second, 33 SNPs, selected in these genes based on their likelihood to functionally affect gene expression/function, were genotyped in an extended sample of 536 LGfMS siblings. Strong associations between ACVR1B genotypes and knee muscle strength (P-values up to 0.00002) were present. Of particular interest was the association with rs2854464, located in a putative miR-24-binding site, as miR-24 was implicated in the inhibition of skeletal muscle differentiation. Rs2854464 AA individuals were B2% stronger than G-allele carriers. The strength increasing effect of the A-allele was also observed in an independent replication sample (n¼266) selected from the Baltimore Longitudinal Study of Aging and a Flemish Policy Research Centre Sport, Physical Activity and Health study. However, no genotype-related difference in ACVR1B mRNA expression in quadriceps muscle was observed. In conclusion, we applied a two-stage fine mapping approach, and are the first to identify and partially replicate genetic variants in the ACVR1B gene that account for genetic variation in human muscle strength.

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Section: Discussionmentioning

confidence: 99%

Section: Fine Mapping Stagementioning

confidence: 99%

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Comprehensive fine mapping of chr12q12-14 and follow-up replication identify activin receptor 1B (ACVR1B) as a muscle strength gene

et al. 2010

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“…As extrinsic factors, myostatin (Mstn), a member of the TGF- superfamily, has been proposed as a regulator of embryonic myogenesis [30,32,34,163,164,165,166]. Myostatin, also called GDF8 (growth differentiation factor 8), is a secreted growth factor that belongs to the transforming growth factor- (TGF-) superfamily of growth and differentiation factors [30].…”

Section: Extrinsic Pathwaymentioning

confidence: 99%

“…Myostatin, also called GDF8 (growth differentiation factor 8), is a secreted growth factor that belongs to the transforming growth factor- (TGF-) superfamily of growth and differentiation factors [30]. In mice, myostatin is predominantly expressed in skeletal muscle tissues from the period of embryogenesis to adulthood suggesting a role for this factor in the control of muscle development and function [30,166]. The role of myostatin in muscle comes from the phenotype of myostatin-deficient animals.…”

Section: Extrinsic Pathwaymentioning

confidence: 99%

Role and Function of Wnts in the Regulation of Myogenesis: When Wnt Meets Myostatin

Fédon¹,

Bonnieu²,

Vernus³

et al. 2012

Skeletal Muscle - From Myogenesis to Clinical Relations

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Hernia Mesh with Biomechanical and Mesh–Tissue Interface Dual Compliance for Scarless Abdominal Wall Reconstruction

Jiao

et al. 2023

Adv Funct Materials

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A fabric hydrogel composite hernia mesh with biomechanical and mesh–tissue interface dual compliance is designed for scarless abdominal wall reconstruction. The mesh is composed of a polyester knitted fabric and chitosan–polyacrylamide hydrogel complex. The mechanical properties of the composite mesh are adjusted to resemble the human abdominal wall by alkali treatment of chitosan to achieve good biomechanical compliance. An adhesion group is introduced into the composite mesh that forms covalent bonds with tissue, eliminating the need for suturing, reducing stress concentration at the fixation site, achieving mesh‐tissue interface compliance, and improving the simplicity of the operation. Covalent bonds and hydrogen bonds make the mesh have strong adhesion (70.1 ± 3.2 kPa) and repeatable (four times) robust adhesiveness. In vivo experiments using a rabbit abdominal wall defect model demonstrate quick adhesiveness and excellent functional reconstruction. Biomechanical and mesh–tissue interface dual compliance allow the tissue to regenerate an intact abdominal wall structure. The adhesive fabric hydrogel composite hernia mesh offers significant clinical values for repairing abdominal wall defects and provides design ideas for repairing other load‐bearing soft tissues.

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Transforming growth factor-β and myostatin signaling in skeletal muscle

Abstract: Kollias HD, McDermott JC. Transforming growth factor-␤ and myostatin signaling in skeletal muscle.

Cited by 276 publications

References 83 publications

Comprehensive fine mapping of chr12q12-14 and follow-up replication identify activin receptor 1B (ACVR1B) as a muscle strength gene

Comprehensive fine mapping of chr12q12-14 and follow-up replication identify activin receptor 1B (ACVR1B) as a muscle strength gene

Role and Function of Wnts in the Regulation of Myogenesis: When Wnt Meets Myostatin

Hernia Mesh with Biomechanical and Mesh–Tissue Interface Dual Compliance for Scarless Abdominal Wall Reconstruction

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