Transforming growth factor‐β family biology: From basic mechanisms to roles in development and disease

Christian, Jan L.; Hill, Caroline S.

doi:10.1002/dvdy.445

Cited by 1 publication

(1 citation statement)

References 14 publications

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“…In addition, many ligands require additional co-receptors. The signals from these receptors are predominantly transduced from the plasma membrane to the nucleus by the SMAD proteins, although several other non-SMAD signaling pathways can be activated in different contexts ( 81 ). This pathway is involved in tumor progression primarily through regulating EMT and immune cells in the tumor microenvironment ( 82 , 83 ).…”

Section: Klfs-mediated Molecular Regulationmentioning

confidence: 99%

Krüppel-like factors in tumors: Key regulators and therapeutic avenues

Zhang

Yao

et al. 2023

Front. Oncol.

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Krüppel-like factors (KLFs) are a group of DNA-binding transcriptional regulators with multiple essential functions in various cellular processes, including proliferation, migration, inflammation, and angiogenesis. The aberrant expression of KLFs is often found in tumor tissues and is essential for tumor development. At the molecular level, KLFs regulate multiple signaling pathways and mediate crosstalk among them. Some KLFs may also be molecular switches for specific biological signals, driving their transition from tumor suppressors to promoters. At the histological level, the abnormal expression of KLFs is closely associated with tumor cell stemness, proliferation, apoptosis, and alterations in the tumor microenvironment. Notably, the role of each KLF in tumors varies according to tumor type and different stages of tumor development rather than being invariant. In this review, we focus on the advances in the molecular biology of KLFs, particularly the regulations of several classical signaling pathways by these factors, and the critical role of KLFs in tumor development. We also highlight their strong potential as molecular targets in tumor therapy and suggest potential directions for clinical translational research.

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Section: Klfs-mediated Molecular Regulationmentioning

confidence: 99%