Transforming growth factor–β overexpression in cutaneous extramedullary hematopoiesis of a patient with myelodysplastic syndrome associated with myelofibrosis

Kawakami, Tamihiro; Kimura, Satoko; Kato, Masayuki; Mizoguchi, Masahiro; Soma, Yoshinao

doi:10.1016/j.jaad.2007.10.489

Cited by 14 publications

(13 citation statements)

References 20 publications

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“…Rarely, cutaneous lesions harboring hematopoietic elements may show dermal sclerosis. The demonstration of transforming growth factor beta in the immature hematopoietic cells may explain the fibrogenic activity (14). However, there was no evidence of fibrosis in the present case.…”

Section: Discussioncontrasting

confidence: 48%

Cutaneous myeloid sarcoma of the penile foreskin

Afrose¹,

Nebhnani²,

Wadhwa³

2013

TJPATH

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Myeloid sarcoma, considered to herald the onset of a blast crisis in the setting of chronic myeloproliferative neoplasm/dysplasia, typically presents during the course of the disorder. Cutaneous involvement is uncommon and lesions on genital skin are seldom seen. We present a case of a well-differentiated myeloid sarcoma in the penile foreskin in an apparently healthy 29-year-old male presenting with phimosis. The unusual composition of the inflammatory cell infiltrate, and characteristic sparing of dermal blood vessels, nerves and smooth muscle fibres led to the correct diagnosis. Absence of commonly observed changes in the circumcision skin like those of balanitis xerotica was also helpful. Detailed hematological work up revealed a previously undiagnosed chronic myeloid leukemia in chronic phase. The patient also had simultaneous priapism, another rare presentation of chronic myeloid leukemia. One year hence, the patient is in hematological remission with no evidence of extramedullary disease. Although priapism has been described as a rare presenting symptom in chronic myeloid leukemia, the present case is unique as this is the first time a cutaneous myeloid sarcoma has been documented in the penile foreskin.

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Section: Discussioncontrasting

confidence: 48%

Cutaneous myeloid sarcoma of the penile foreskin

Afrose¹,

Nebhnani²,

Wadhwa³

2013

TJPATH

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“…Literature documentation of CEMH comprises a total of about 30 cases and appears to be most frequently associated with myelofi brosis or myeloproliferative disorders (Patel et al 1995 ;Revenga et al 2000 ;Fernandez Acenero et al 2003 ). Increased levels of transforming growth factor-beta appear to be associated with CEMH in patients with idiopathic myelofi brosis ( Collie et al 2013 ;Corella et al 2008 ;Haniffa et al 2006 ;Kawakami et al 2008 ;Kwon et al 1999 ;Lane et al 2002 ;Miyata et al 2008 ;Mizoguchi et al 1990 ;Pagerols et al 1998 ;Rodriguez et al 1991 ;Rogalski et al 2002 ;Ruberto et al 1995 ).…”

Section: Pyoderma Gangrenosum Associated With G-csfmentioning

confidence: 99%

Cutaneous Hematopathology

2014

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“… 1 , 2 , 3 However, the mechanism underlying the specific migration of myeloblasts to the skin remains uncertain. In 2008, Kawakami et al 4 presumed that transforming growth factor–beta 1 (TGF-β1) released by hematopoietic cells within the cutaneous extramedullary hematopoiesis could play a role in the onset of such skin lesions. 4 …”

Section: Introductionmentioning

confidence: 99%