Transforming growth factor-β-related proteins: an ancestral and widespread superfamily of cytokines in metazoans

Herpin, Amaury; Lelong, Christophe; Favrel, Pascal

doi:10.1016/j.dci.2003.09.007

Cited by 205 publications

(158 citation statements)

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“…Drosophila, Anopholes, and C. elegans contain TGF-␤ homologues, but no distinct nodal subfamily member (Adams et al, 2000;Holt et al, 2002;C. elegans Sequencing Consortium, 1998;Herpin et al 2004). However, nodal may be present and play an active role in the development of the third major metazoan group, the lophotrochozoa.…”

Section: Discussionmentioning

confidence: 99%

“…Many members of the transforming growth factor-␤ (TGF-␤) superfamily of signaling molecules are involved in body plan determination during embryogenesis in vertebrates (Whitman, 1998;Herpin et al, 2004). TGF-␤ growth factor ligands act through a signal transduction pathway and bind to specific cell surface receptors identified as type I and type II receptors (Massagú e, 1998;Whitman, 1998;Schier and Shen, 2000;Mehra and Wrana, 2002).…”

Section: Nodal Is Part Of the Tfg-␤ Superfamily Of Signaling Moleculesmentioning

confidence: 99%

“…In vertebrates, the type I receptor activates Smad2 or related Smad proteins, which act with transcription cofactors to effect transcription at the nuclear level, activating downstream genes (Massagú e, 1998;Whitman, 1998;Schier and Shen, 2000;Wrana, and Pawson, 1997). This signaling pathway, including the ligand, receptors, and Smad proteins, is highly conserved among all vertebrates studied (Whitman, 2001) and is also highly conserved in invertebrates (Herpin et al 2004). Nodal, a TGF-␤ ligand, associates with EGF-CFC cofactors to bind to its receptors (Cheng et al, 2004;Herpin et al, 2004).…”

Section: Nodal Is Part Of the Tfg-␤ Superfamily Of Signaling Moleculesmentioning

confidence: 99%

“…This signaling pathway, including the ligand, receptors, and Smad proteins, is highly conserved among all vertebrates studied (Whitman, 2001) and is also highly conserved in invertebrates (Herpin et al 2004). Nodal, a TGF-␤ ligand, associates with EGF-CFC cofactors to bind to its receptors (Cheng et al, 2004;Herpin et al, 2004). Nodal plays a regulatory role in cell interactions that are re- In echinoderms and hemichordates, invagination of the endoderm begins at the vegetal pole and the early gastrula is radially symmetrical.…”

Section: Nodal Is Part Of the Tfg-␤ Superfamily Of Signaling Moleculesmentioning

confidence: 99%

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Nodal signaling and the evolution of deuterostome gastrulation

Chea

Wright

Swalla

2005

Developmental Dynamics

101

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Chordates, including vertebrates, evolved within a group of animals called the deuterostomes. All holoblastic deuterostomes gastrulate at the vegetal pole and the blastopore becomes the anus, while a mouth is formed at the anterior or to the oral side. Nodal is a member of the TGF-␤ superfamily of signaling molecules that are important in signaling between cells during many embryonic processes in vertebrate embryos. Nodal has also been found in other invertebrate deuterostomes, such as ascidians and sea urchins, but, so far, is missing in protostomes. Nodal has been shown to be particularly important in determining left-right asymmetries in vertebrate embryos, but less information is available for its developmental role in the invertebrate deuterostomes. We review gastrulation in the deuterostomes, then examine nodal expression early during mesoderm formation and later during the establishment of asymmetries in both vertebrates and invertebrates. Nodal is expressed asymmetrically on the left side in chordates and on the presumptive oral side of the embryo in echinoid echinoderms. The expression of nodal is in different germ layers in embryos of different phyla. Expression is in the ectoderm in most of the invertebrate deuterostomes, and in the mesoderm in vertebrates. We summarize the work that has been published to date, especially nodal expression in the invertebrate deuterostomes, and suggest future experiments to better understand the evolution of nodal signaling and deuterostome gastrulation. Developmental Dynamics 234:269 -278, 2005.

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Section: Discussionmentioning

confidence: 99%

Section: Nodal Is Part Of the Tfg-␤ Superfamily Of Signaling Moleculesmentioning

confidence: 99%

Section: Nodal Is Part Of the Tfg-␤ Superfamily Of Signaling Moleculesmentioning

confidence: 99%

Section: Nodal Is Part Of the Tfg-␤ Superfamily Of Signaling Moleculesmentioning

confidence: 99%

See 2 more Smart Citations

Nodal signaling and the evolution of deuterostome gastrulation

Chea

Wright

Swalla

2005

Developmental Dynamics

101

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“…The functions of TGF-β family members are executed mainly through binding to type I and type II receptors, thus initiating a post-receptor signaling cascade (Derynck et al, 1996). The TGF-β signaling pathway has been shown to play an important role in many biological functions including the regulation of the extracellular matrix components and enzymes (Herpin et al, 2004). The TGF-β signaling pathway can regulate the amount and activity of the LOX family (LOX, LOXL1 to LOXL4) in human trabecular meshwork cells (Sethi et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Estradiol plays a role in regulating the expression of lysyl oxidase family genes in mouse urogenital tissues and human Ishikawa cells

Zong

Jiang

Zhao

et al. 2015

J. Zhejiang Univ. Sci. B

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Abstract:The lysyl oxidase (LOX) family encodes the copper-dependent amine oxidases that play a key role in determining the tensile strength and structural integrity of connective tissues by catalyzing the crosslinking of elastin or collagen. Estrogen may upregulate the expression of LOX and lysyl oxidase-like 1 (LOXL1) in the vagina. The objective of this study was to determine the effect of estrogen on the expression of all LOX family genes in the urogenital tissues of accelerated ovarian aging mice and human Ishikawa cells. Mice and Ishikawa cells treated with estradiol (E2) showed increased expression of LOX family genes and transforming growth factor β1 (TGF-β1). Ishikawa cells treated with TGF-β1 also showed increased expression of LOX family genes. The Ishikawa cells were then treated with either E2 plus the TGF-β receptor (TGFBR) inhibitor SB431542 or E2 alone. The expression of LOX family genes induced by E2 was reduced in the Ishikawa cells treated with TGFBR inhibitor. Our results showed that E2 increased the expression of the LOX family genes, and suggest that this induction may be mediated by the TGF-β signal pathway. E2 may play a role in regulating the expression of LOX family genes.

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Tacorin, an extract from Ananas comosus stem, stimulates wound healing by modulating the expression of tumor necrosis factor α, transforming growth factor β and matrix metalloproteinase 2

Rahayu¹,

Agustina²,

Tjandrawinata³

2017

FEBS Open Bio

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Wound healing is a complex biological process that involves integration of hemostasis, inflammation, proliferation and tissue remodeling. An extract of pineapple ( Ananas comosus ) stem demonstrates several therapeutics properties, including acceleration of wound healing. Tacorin is a water crude extract derived from the stem of A. comosus with high protein content. The effect of tacorin on wound healing in vivo was examined using rats with an induced injury. Wound closure was faster with tacorin treatment than in the untreated group. An in vitro study was conducted on mammalian cells (3T3‐L1) to observe the effect of tacorin on cell proliferation. Tacorin was first heated to inactivate its proteolytic activity. It increased the viability of 3T3‐L1 cells in a dose‐dependent manner. Excessive inflammation was suppressed by tacorin as shown by decreased tumor necrosis factor α expression. Treatment with tacorin increased the expression of transforming growth factor β, a major player in tissue remodeling. Moreover, tacorin also reduced the expression of MMP‐2 to accelerate the recovery of the wound. Taken together, tacorin is able to accelerate the wound‐healing process by increasing cell proliferation, suppressing inflammation and accelerating tissue remodeling.

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Transforming growth factor-β-related proteins: an ancestral and widespread superfamily of cytokines in metazoans

Cited by 205 publications

References 135 publications

Nodal signaling and the evolution of deuterostome gastrulation

Nodal signaling and the evolution of deuterostome gastrulation

Estradiol plays a role in regulating the expression of lysyl oxidase family genes in mouse urogenital tissues and human Ishikawa cells

Tacorin, an extract from Ananas comosus stem, stimulates wound healing by modulating the expression of tumor necrosis factor α, transforming growth factor β and matrix metalloproteinase 2

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