Transforming growth factor-β1 gene polymorphisms are associated with progression of liver fibrosis in Caucasians with chronic hepatitis C infection

Wang, Hao; Mengsteab, Senait; Tag, Carmen G.; Gao, Chunfang; Hellerbrand, Claus; Lammert, Frank; Gressner, A. M.; Weiskirchen, Ralf

doi:10.3748/wjg.v11.i13.1929

Cited by 77 publications

(56 citation statements)

References 50 publications

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“…Genomic DNA was extracted from peripheral blood cells using the QIAamp DNA Blood Mini extraction kit (Qiagen, Hilden, Germany). The primers, cycling conditions, and melting curve analysis were in referring to our previous publication (17). The fluorescencelabeled primers were obtained from Metabion (Metabion, Martinsried, Germany), and the common PCR-primers were synthesized at MWG-Biotech AG (Ebersberg, Germany).…”

Section: Tgfβ1 Gene Snp Analysis In Lightcycler Systemmentioning

confidence: 99%

Laboratory Characterizations on 2007 Cases of Monoclonal Gammopathies in East China

Wang

Gao

et al. 2008

Cell Mol Immunol

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Section: Tgfβ1 Gene Snp Analysis In Lightcycler Systemmentioning

confidence: 99%

Laboratory Characterizations on 2007 Cases of Monoclonal Gammopathies in East China

Wang

Gao

et al. 2008

Cell Mol Immunol

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“…The G→C transition at position 915 of the TGF-β1 signal sequence causes the amino acid sequence to change from arginine to proline in codon 25. A number of previous studies reported the association between this SNP and susceptibility to chronic HCV infection (14)(15)(16)(17)(18)(19)(20)(21). However, the currently available results are controversial.…”

Section: Introductionmentioning

confidence: 78%

“…1. Finally, 8 eligible studies including a total of 1,542 participants (910 cases and 632 controls) were identified (14)(15)(16)(17)(18)(19)(20)(21). A summary of the characteristics of each study, including first author, year of publication, ethnicity of cases and controls, genotyping methods, number of cases and Table I.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, we could only calculate pooled OR with its 95% CI for a Caucasian population and there was no association between TGFB1 915G/C polymorphism and susceptibility to chronic HCV infection in that population. As regards genotyping methods, there was also only one study using polymerase chain reaction (PCR)-restriction fragment length polymorphism (15), LightCycler (Roche, Basel, Switzerland) (19) and PCR sequence-specific primers (16), respectively. As regards the methods of PCR-direct sequencing and amplification-refractory mutation system-PCR, a subgroup analysis Table IV.…”

Section: Meta-analysis For Tgfb1 915g/c Polymorphismmentioning

confidence: 99%

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Association between TGFB1 915G/C polymorphism and susceptibility to chronic hepatitis C virus infection: A meta-analysis

Zheng

Liu

2014

Biomedical Reports

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Abstract. The human transforming growth factor-β1 (TGF-β1) gene, namely TGFB1, contains several single-nucleotide polymorphisms (SNPs) and some of the polymorphic variants were shown to affect the TGF-β1 protein levels. A number of studies reported the association between 915G/C polymorphism and susceptibility to chronic hepatitis C virus (HCV) infection. However, the results were inconsistent. This meta-analysis was conducted to assess the association of TGFB1 915G̸C polymorphism with susceptibility to chronic HCV infection. PubMed, ISI Web of Knowledge, ScienceDirect and Google Scholar databases were systematically searched up to August, 2013 to identify relevant studies. The pooled odds ratios (ORs) with their corresponding 95% confidence intervals (95% CIs) were calculated in 5 genetic comparison models (C vs. G, CC vs. GG, GC vs. GG, CC vs. GG+GC and CC+GC vs. GG). The Galbraith plot and subgroup analyses based on ethnicity, genotyping methods, sample size and fibrosis were performed to investigate possible sources of heterogeneity. A sensitivity analysis and assessment of publication bias were also conducted. Finally, 8 eligible case-control studies on TGFB1 915G/C polymorphism, including a total of 910 cases and 632 controls, were included in this meta-analysis. Overall, there was no evidence of any gene-disease association obtained from the subgroup analyses. Therefore, this meta-analysis demonstrated that there is no association between TGFB1 915G/C polymorphisms and susceptibility to chronic HCV infection.

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“…By contrast, Qi et al (2009) reported that the TGF-β1 -509 CC genotype was associated with hepatitis B virus-related HCC in a Chinese population. In another study, Wang et al (2005) reported that the C allele of TGF-β1 -509, but not the T allele, might play an important role in the progression of liver cirrhosis. The differences in these results may have been caused by different clinical characteristics and the different ethnic groups studied.…”

Section: Discussionmentioning

confidence: 99%

TGF-β1 polymorphism 509 C>T is associated with an increased risk for hepatocellular carcinoma in HCV-infected patients

Ma¹,

Liu²,

Fang³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Transforming growth factor-beta 1 (TGF-β1), a member of the transforming growth factor beta family, functions as a multi-functional cytokine and plays a key role in cellular growth, proliferation, and differentiation. The 509 C/T polymorphism in the TGF-β1 gene has been implicated in the outcome of hepatitis C virus (HCV) infection; however, little is known regarding the relationship between TGF-β1 gene mutations and the development of hepatocellular carcinoma (HCC) in HCV-infected patients. The aim of the study was to evaluate the effect of the TGF-β1 polymorphisms 509 C>T on the occurrence of HCC in patients chronically infected with HCV in a Chinese Han population. The results showed that HCC patients had a higher frequency of the TGF-β1 -509 TT genotype distribution of the TGF-β1 -509 polymorphism and a lower frequency of the CC genotype. Serum TGF-β1 levels were significantly higher in patients with the TT genotype than in those with the CC genotype. In this study, we confirmed that the TGF-β1 polymorphism 509 C>T is associated with the risk of HCC in HCV-infected patients.

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Transforming growth factor-β1 gene polymorphisms are associated with progression of liver fibrosis in Caucasians with chronic hepatitis C infection

Abstract: In summary, these results confirm the hypothesis that TGF-beta1 polymorphisms are associated with fibrosis progression in Caucasians chronically infected with hepatitis C.

Cited by 77 publications

References 50 publications

Laboratory Characterizations on 2007 Cases of Monoclonal Gammopathies in East China

Laboratory Characterizations on 2007 Cases of Monoclonal Gammopathies in East China

Association between TGFB1 915G/C polymorphism and susceptibility to chronic hepatitis C virus infection: A meta-analysis

TGF-β1 polymorphism 509 C>T is associated with an increased risk for hepatocellular carcinoma in HCV-infected patients

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