Transforming growth factor β1 (TGFβ1) expression in head and neck squamous cell carcinoma patients as related to prognosis

Abstract

TGFbeta1-positive expression was found in 47.2% of larynx, 36.7% of oral cavity/oropharynx and in 24% of the hypopharynx tumors. Reactivity in >60% of the cells was displayed only by 11.4% of HNSCC. All normal controls were positive. TGFbeta1-positive expression did not correlate with clinico pathological parameters. An association with differentiation was verified only in oral cavity/oropharynx tumors (P </= 0.001). TGFbeta1 was also not related to 5 years survival (Kaplan-Meier). Strong and diffuse expression of TGFbeta-RII was identified in 19/20 cases regardless of TGFbeta1 immunoreactivity. Out of 17 TGFbeta1-positive oral cavity/oropharynx tumors, only nine expressed TGFbeta-RI suggesting a disruption of the TGFbeta1 pathway. We conclude that TGFbeta1 protein immunostaining is not a useful biomarker in assessment of prognosis in HNSCC.

The Expression and Clinical Significance of TGF-β1 and MMP2 in Human Renal Clear Cell Carcinoma

“…Consequently, overexpressed TGF-β1 can function to promote tumor cell growth and progression, in the absence of antitumor actions. 2, 19 We believe such an imbalance in TGF-β1 actions occurs in RCCC tumors as well.…”

Expression of transforming growth factor-beta-1 and p27Kip1 in pancreatic adenocarcinomas: relation with cell-cycle-associated proteins and clinicopathologic characteristics

“…In pancreatic cancers, all three TGF-β isoforms are expressed at high levels and the presence of TGF-β isoforms is associated with shorter postoperative survival [34]. TGF-β isoforms were also markedly increased in hepatocellular carcinoma and prostate carcinoma [35-37]. Overproduction of TGF-β1 and loss of TGF-β-RII expression were found to be associated with poor clinical outcome [10].…”

Abnormal expression of Endoglin and its receptor complex (TGF-β1 and TGF-β receptor II) as early angiogenic switch indicator in premalignant lesions of the colon mucosa

“…Multivariate analysis indicated that only plasma TGF-ß1 levels were an independent and significant prognostic factor of disease-free survival, associated with increased risk of poor prognosis. Both TGF-ß1 and Endoglin act as valuable indicators of prognosis in several tumors (56,70,(87)(88)(89)(90)(91)(92)(93)(94)(95)(96)(97).…”