Transforming Wound Management: Nanomaterials and Their Clinical Impact

T, Ashwini; Prabhu, Ashlesh; Baliga, Vishal; Bhat, Shreesha; Thenkondar, Siddarth T.; Nayak, Yogendra; Nayak, Usha Y.

doi:10.3390/pharmaceutics15051560

Cited by 17 publications

(4 citation statements)

References 161 publications

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“…In addition, appropriate antimicrobial action can be achieved by controlling the size and shape of nanopreparations. In wound healing, nanomaterials have shown the potential to promote cell proliferation, migration, angiogenesis, and extracellular matrix remodeling and prevent infections ( 123 ). Therefore, nanoparticles are more suitable for many purposes than macroscopic materials.…”

Section: Classification and Active Ingredients Of Dressingsmentioning

confidence: 99%

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Current status and progress in research on dressing management for diabetic foot ulcer

Jiang,

Li,

Luo

et al. 2023

Front. Endocrinol.

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Diabetic foot ulcer (DFU) is a major complication of diabetes and is associated with a high risk of lower limb amputation and mortality. During their lifetime, 19%–34% of patients with diabetes can develop DFU. It is estimated that 61% of DFU become infected and 15% of those with DFU require amputation. Furthermore, developing a DFU increases the risk of mortality by 50%–68% at 5 years, higher than some cancers. Current standard management of DFU includes surgical debridement, the use of topical dressings and wound decompression, vascular assessment, and glycemic control. Among these methods, local treatment with dressings builds a protective physical barrier, maintains a moist environment, and drains the exudate from DFU wounds. This review summarizes the development, pathophysiology, and healing mechanisms of DFU. The latest research progress and the main application of dressings in laboratory and clinical stage are also summarized. The dressings discussed in this review include traditional dressings (gauze, oil yarn, traditional Chinese medicine, and others), basic dressings (hydrogel, hydrocolloid, sponge, foam, film agents, and others), bacteriostatic dressings, composite dressings (collagen, nanomaterials, chitosan dressings, and others), bioactive dressings (scaffold dressings with stem cells, decellularized wound matrix, autologous platelet enrichment plasma, and others), and dressings that use modern technology (3D bioprinting, photothermal effects, bioelectric dressings, microneedle dressings, smart bandages, orthopedic prosthetics and regenerative medicine). The dressing management challenges and limitations are also summarized. The purpose of this review is to help readers understand the pathogenesis and healing mechanism of DFU, help physicians select dressings correctly, provide an updated overview of the potential of biomaterials and devices and their application in DFU management, and provide ideas for further exploration and development of dressings. Proper use of dressings can promote DFU healing, reduce the cost of treating DFU, and reduce patient pain.

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Section: Classification and Active Ingredients Of Dressingsmentioning

confidence: 99%

“…Structural relationship, need for easier exfoliation of particles, and dispersion. Cost-efficiency ( 123 ).…”

Section: Classification and Active Ingredients Of Dressingsmentioning

confidence: 99%

Current status and progress in research on dressing management for diabetic foot ulcer

Jiang,

Li,

Luo

et al. 2023

Front. Endocrinol.

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“…Wound management remains a great challenge worldwide, and effective strategies for enhanced wound healing are urgently needed. 1 Extracellular vesicles (EVs) are cell-secreted lipid bilayer vesicles encapsulated with diverse bioactive molecules 2 and less immunogenic compared with cells. 3 Notably, plateletderived extracellular vesicles (PEVs) showing great potential in the development of new biotherapies in wound healing have attracted increasing attention in the recent years.…”

Section: Introductionmentioning

confidence: 99%

“…Wound management remains a great challenge worldwide, and effective strategies for enhanced wound healing are urgently needed . Extracellular vesicles (EVs) are cell-secreted lipid bilayer vesicles encapsulated with diverse bioactive molecules and less immunogenic compared with cells .…”

Section: Introductionmentioning

confidence: 99%

Self-Assembled DNA Microflowers for Platelet-Derived Extracellular Vesicle Isolation and Infected Wound Healing

Zhu,

Fan,

et al. 2024

Biomacromolecules

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Platelet-derived extracellular vesicles (PEVs) showing great potential in wound healing have attracted increasing attention recently. Nondestructive isolation and effective utilization strategies are highly conducive for PEVs developing into recognized therapeutic entities. Here, we present an efficient strategy for PEV isolation and bacterial infected wound healing based on self-assembled DNA microflowers. First, DNA microflowers are prepared using rolling circle amplification. Then, the hydrophobic interaction between cholesteryl modified on DNA microflowers and the phospholipid bilayer membrane of PEVs leads to the formation of a network structure with improved mechanical strength and the separation of PEVs from biological samples. Finally, controlled release of PEVs is achieved through bacterial-induced hydrogel degradation. In vitro experiments demonstrate the obtained DNA hydrogel with good cytocompatibility and therapeutic potential. Taken together, the DNA microflower-based hydrogels with bioadhesive, self-healing, tunable mechanical properties and bacteria-responsive behavior offer substantial potential for EV isolation and wound healing.

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