Transfusion associated graft versus host disease

Naveen, K; Athanker, Sharatchandra B; Rajoor, Umesh; Sindhoor, Jayaraj

doi:10.4103/0019-5154.156477

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…Lymphocytes carry plenty of speci c human leucocyte antigens which might be recognized by the immune system of blood recipient and caused host in ammatory and immune cascade reaction [24]. Secondly, it is reported that the transfusion-related GVHD was caused by viable or immunocompetent lymphocytes that from the transfusion of stored blood products [25,26]. Moreover, leukocyte may release some pro-in ammatory factors during storage [27].…”

Section: Discussionmentioning

confidence: 99%

Stored Whole Blood Transfusion Initiate Serum Amyloid A Activation Monitored by Real-Time Dynamic Imaging

Zhang¹,

Wang²,

Liu³

et al. 2020

Preprint

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BACKGROUND: Transfusion of stored whole blood (SWB) is increasingly routine practice to resuscitate severe traumatic hemorrhage patients in military operations and civilian emergency centers. It has been well established that transfusion of red blood cells (RBCs) after prolonged storage exerts harmful effects that are mainly mediated by inflammation. Whether the storage lesion that related to inflammation will happen in SWB remains unclear.METHODS: A hepatocyte SAA (serum amyloid A) specific reporter mouse that facilitated non-invasive imaging of hepatocyte SAA expression was used for the evaluation of acute inflammation and acute-phase reaction after the transfusion of SWB or components separated from end-stage whole blood. Donor C57BL/6 mouse whole blood was used to model an allogeneic transfusion in Balb/C mouse recipients. RESULTS: End-stage whole blood (14 days of storage) transfusion induced the most significant SAA expression, while 10-day-storage evoked much weaker signal compared to their fresh and 5-day-storage counterparts. It was RBCs rather than white blood cells and plasma-containing platelets that should be responsible for the systemic inflammatory and SAA activation during end-stage whole blood transfusion. Circulatory and hepatic pro-inflammatory cytokines induced the SAA expression in hepatocyte. The macrophage M1 polarization aroused by SWB activated SAA through nuclear transcription factor NF-κB. CONCLUSION: Storage lesion will also happen during the storage of whole blood, which is related to the change of RBCs after prolonged storage. The side effect induced by systemic inflammation and acute-phase reaction should be taken into consideration before resuscitation by long-term storage whole blood transfusion.

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Section: Discussionmentioning

confidence: 99%

Stored Whole Blood Transfusion Initiate Serum Amyloid A Activation Monitored by Real-Time Dynamic Imaging

Zhang¹,

Wang²,

Liu³

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…The clinical signs and symptoms of TA-GVHD are: fever, increased hepatic enzymes, diarrhea, rash progressing from peeling and they occur from three to thirty days after the transfusion [21]. The treatment of TA-GVHD is not effective, so the irradiation of the cell blood components is fundamental for prevention, especially in patients who are in the risk group for developing TA-GVHD [29,[49][50][51].…”

Section: Transfusion-associated Graft-versus-host Disease -Gvhdmentioning

confidence: 99%

Transfusion reaction and hemovigilance: An imperative discussion in Brazilian hemotherapy services

Santos

Alzamora²,

Teles³

et al. 2017

int arch med

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Transfusion of blood components is considered safer, but it took years to reach this level. One of the most effective ways to make blood transfusion a safer practice is hemovigilance, which provides important data, including the history of feared transfusion reactions. In recent years in Brazil, there has been an improvement in the reporting of transfusion reactions, however due to the great diversity of hematology services, there are still transfusion reactions. The aims of this study were described the main types of transfusion reactions, as well as to evaluate the underreporting importance of transfusion occurrences of hemotherapy services in Brazil.

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Evaluación de la eficacia de un irradiador terapéutico para la irradiación de concentrados eritrocitarios, en Oaxaca, México

Luis

Canales

Matos³

et al. 2016

Acta Universitaria

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La enfermedad injerto contra hospedero asociada a la transfusión (EICH-AT) es una reacción postransfusional grave debido al injerto de linfocitos residuales (LR) presentes en los componentes sanguíneos. El objetivo de este trabajo fue evaluar la eficacia del irradiador terapéutico THERATRON® Phoenix™ (cobalto 60) del Centro de Oncología y Radioterapia de Oaxaca, México, para eliminar la capacidad de proliferación de los LR en concentrados eritrocitarios (CR). Para este fin, se obtuvieron siete concentrados eritrocitarios de donadores de sangre seleccionados según los criterios de las normas oficiales nacionales, los cuales fueron irradiados a 2520 cGy; y se cuantificaron parámetros para evaluar la conservación del potencial terapéutico de los concentrados eritrocitarios (hemoglobina, hematocrito, hemólisis e hiperkalemia) y de efectividad para inactivar a los LR (número, viabilidad y capacidad proliferativa). El irradiador preservó la calidad e incrementó la seguridad transfusional de estos componentes sanguíneos al eliminar la capacidad proliferativa de los LR, y el análisis de costo-efectividad demostró su eficiencia para este proceso. Tomando como base estos resultados, se proponen estos parámetros como control de calidad para la validación de irradiadores terapéuticos y/o de rayos X para la irradiación de concentrados eritrocitarios, así como la difusión de este servicio en todo el país, con la finalidad de reducir la incidencia de la enfermedad injerto contra hospedero asociada a la transfusión.

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Transfusion associated graft versus host disease

Cited by 3 publications

References 7 publications

Stored Whole Blood Transfusion Initiate Serum Amyloid A Activation Monitored by Real-Time Dynamic Imaging

Stored Whole Blood Transfusion Initiate Serum Amyloid A Activation Monitored by Real-Time Dynamic Imaging

Transfusion reaction and hemovigilance: An imperative discussion in Brazilian hemotherapy services

Evaluación de la eficacia de un irradiador terapéutico para la irradiación de concentrados eritrocitarios, en Oaxaca, México

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