Transfusion issues in cancer patients

Federici, Augusto B.; Vanelli, Chiara; Arrigoni, Luisa

doi:10.1016/s0049-3848(12)70018-x

Cited by 10 publications

(6 citation statements)

References 19 publications

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“…Published guidelines based on “expert opinion” recommends transfusion of plasma for the following clinical indications: active bleeding in the setting of multiple coagulation factor deficiencies (massive transfusions, disseminated intravascular coagulation); emergency reversal of warfarin in patients with active bleeding in settings where prothrombin complex concentration with adequate level of factor VII is not available; and for use as replacement when performing plasma exchange [ 26 – 30 ]. Specifically, these are seen in burns [ 31 , 32 ], oncology [ 33 ], obstetric events [ 34 – 36 ], and more. Packed red cells are indicated in conditions requiring prevention of anemia related tissue hypoxia [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Demographic characteristics of blood and blood components transfusion recipients and pattern of blood utilization in a tertiary health institution in southern Nigeria

Okoroiwu

Okafor

2018

BMC Hematol

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BackgroundAn insight into the utilization pattern helps in future planning of blood drive. This study was conducted to describe the demographic characteristics of the transfusion recipients and pattern of blood and blood product utilization in Nigeria.MethodsBlood bank registers of University of Calabar Teaching Hospital (UCTH) Calabar were analysed for a 12 month period. Number of blood units requested, number of units issued, Cross-match to transfusion ratio (C/T), age, gender, blood group, blood components received, patients ward and clinical diagnosis were computed. Diagnoses were grouped into broad categories according to the disease headings of International Classification of Diseases (ICD-10).ResultsMajority of the 2336 transfusion recipients studied were females (69.09%) and are in the reproductive age group; 15–49 years (75.23%). The median age of the recipients was 35 years (range, 0–89). Most of the recipients (n = 1636; 70.04%) received whole blood transfusion. Majority (94.46%) of the cross–matched units were issued giving C/T ratio of 1.06. The common blood group type was O Rhesus positive (62.63%). Obstetrics and Gynecology had the highest blood requisition (41.40%). The majority of the patients were diagnosed with conditions related to pregnancy and childbirth (38.70%), conditions originating in prenatal period (14.38%). The age range of 25–54 years had the highest blood transfusion requests (n = 501; 51.07%), of these, females were majority (n = 390;77.84%).ConclusionsOur study recorded mostly young patients who received mostly whole blood. Most of the patients in the reproductive age group received transfusion for pregnancy and child-birth related cases.

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Section: Discussionmentioning

confidence: 99%

Demographic characteristics of blood and blood components transfusion recipients and pattern of blood utilization in a tertiary health institution in southern Nigeria

Okoroiwu

Okafor

2018

BMC Hematol

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“…This issue appeared to be more interesting than expected at the beginning of this research, due to the fact that, more than 50 percent of the administered PCs at the University Hospital Regensburg underwent irradiation in the past year. Gamma irradiation of 25 Gy exposed to PCs prevents the proliferation of leukocytes before transfusion (284,285). This process reduces the potential life-threatening transfusion associated graft-versus-host disease (TA-GvHD) in immunocompromised patients.…”

Section: Discussionmentioning

confidence: 99%

“…We investigated a potential effect of gamma irradiation on PLT vesiculation. Irradiation of 25 Gy exposed to PCs prevents the proliferation of WBCs to reduce graft‐versus‐host disease. Results of PLT vesiculation in PCs after gamma irradiation have not yet been reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Platelet‐derived extracellular vesicles in plateletpheresis concentrates as a quality control approach

et al. 2015

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BACKGROUND Platelet‐derived extracellular vesicles (PL‐EVs) are present in plateletpheresis concentrates (PCs) and may influence the quality of PCs. The aim of the study was to analyze PC‐derived PL‐EVs and to correlate them with standard quality control (QC) variables of PCs and with donor‐specific laboratory variables. STUDY DESIGN AND METHODS PL‐EVs were analyzed by standard as well as advanced high‐sensitivity flow cytometry (FCM) and nanoparticle tracking analysis. A hematology analyzer was applied to the determination of platelet (PLT) count and immature PLT fraction (IPF). Functional capacity of PLTs (CD62P in response to thrombin receptor‐activating peptide 6 activation) was measured by FCM. All in vitro measurements were carried out on Day 0 and on Day 5. Altogether, a total of 42 PC samples, 15 irradiated on Day 0, were investigated. RESULTS Externalization of CD62P, as an indicator of intact PLT function, significantly decreased during in vitro PLT senescence and CD62P expression inversely correlated with increased PL‐EV levels. Interestingly, in fresh PCs a significant correlation was found between PL‐EVs and different hemapheresis instruments, duration of apheresis, and IPF count in peripheral blood of the donor before apheresis. In senescent PCs, the body mass index of donors inversely correlated with the PL‐EV counts. CONCLUSION Loss of PLT function in PCs was associated with increased PL‐EV levels. Shedding of PL‐EVs depends on shear stress influenced by different hemapheresis settings and diverse preanalytical conditions of donors. PL‐EV analysis may stimulate new quality and apheresis strategies for more vital PLTs for transfusion.

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“…A terapêutica transfusional é uma prática importante e comum nos pacientes portadores de doenças oncohematológicas como os diversos tipos de leucemias, linfomas e Síndromes Mieolodisplásicas (Singhal, et al, 2017). Ela tem como objetivo melhorar a capacidade de transporte de oxigênio e o fluxo de sangue na microcirculação (Federici, et al, 2012).…”

Section: Discussionunclassified

Aloimunização eritrocitária em pacientes politransfundidos com doenças onco-hematológicas: Uma revisão de literatura

Ramos

2021

RSD

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O objetivo desta revisão de literatura foi avaliar quais são as doenças onco-hematológicas mais frequentes em pacientes politransfundidos aloimunizados, determinar quais são os antígenos eritrocitários e os aloanticorpos antieritrocitários mais comuns detectados no perfil populacional do estudo, assim como identificar medidas adequadas a serem tomadas a fim de minimizar as taxas de aloimunização nesta população dependente de transfusão. Foram utilizados critérios de elegibilidade bem delineados e a busca ocorreu na base de dados bibliográfica eletrônica Medical Literature Analysis and Retrieval System Online (MEDLINE). A partir dos critérios utilizados foram incluídos 10 artigos para compor esta revisão.Verificou-seque a doença onco-hematológica mais prevalente na população estudada foi a Síndrome Mielodisplásica e os aloanticorpos detectados com maior frequência foram os associados aos sistemas Rh, Kell, MNS e Kidd. Todos os trabalhos apontaram a fenotipagem eritrocitária extensa como forma de minimizar as taxas de aloimunização entre os pacientes com neoplasias hematológicas, assim como reduzir os riscos de ocorrência de reações hemolíticas transfusionais. Portanto, a realização da fenotipagem e genotipagem para a identificação de outros sistemas além do ABO/Rh, principalmente para os pacientes cronicamente transfundidos e que apresentam Síndrome Mielodisplásica, pode minimizar o risco de aloimunização e suas consequências com reflexos positivos na segurança e eficácia da terapia transfusional.

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Transfusion issues in cancer patients

Cited by 10 publications

References 19 publications

Demographic characteristics of blood and blood components transfusion recipients and pattern of blood utilization in a tertiary health institution in southern Nigeria

Demographic characteristics of blood and blood components transfusion recipients and pattern of blood utilization in a tertiary health institution in southern Nigeria

Platelet‐derived extracellular vesicles in plateletpheresis concentrates as a quality control approach

Aloimunização eritrocitária em pacientes politransfundidos com doenças onco-hematológicas: Uma revisão de literatura

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