Transfusion Medicine — Blood Transfusion

Goodnough, Lawrence T.; Brecher, Mark E.; Kanter, Michael H.; AuBuchon, James P.

doi:10.1056/nejm199902113400606

Cited by 817 publications

(208 citation statements)

References 99 publications

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“…Through autologous blood transfusion systems, allogeneic blood exposure is expected to decrease along with the well-known complications of transfusion reactions through storage-induced mechanisms, allergic reactions, errors in application and administration, immunosuppression and viral contamination (cytomegalovirus, human immunodeficiency virus, hepatitis B/C) [5][6][7][8][9]. In addition, there are economic considerations and limited supply of allogeneic blood transfusions (ABT).…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of an autologous transfusion system following cemented and non-cemented revisions of total hip arthroplasty

Hawi

Kendoff

Hessling

et al. 2014

International Orthopaedics (SICOT)

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Purpose The goal of this study was to analyse the efficacy of blood autotransfusion using a continuous autologous transfusion system in revisions of total hip arthroplasty (THA). We looked at whether administration of allogeneic blood units was reduced in these cases and if there is a difference between cemented and non-cemented revisions. Methods Between January 2011 and December 2011, patients being treated with revision THA were included (n=411). The following parameters were analysed: patient age, gender, weight (kg), height (cm), body mass index (BMI, kg/m 2 ), surgical diagnosis, treatment and American Society of Anesthesiologists (ASA) classification score. The difference between pre-and post-operative haemoglobin (Hb, g/dl), amount of peri-operative blood loss (ml), amount of retransfused washed shed blood and amount of allogeneic and/or autologous transfusion (ml) were recorded. Results In both the cemented and non-cemented revision THA groups, there was no significant difference between pre-and post-operative Hb with or without using an autotransfusion system. In 92 of 186 cemented cases using an autologous transfusion system (49.5 %) and 38 of 117 non-cemented cases using an autologous transfusion system (32.5 %), allogeneic blood transfusion (ABT) was required. Cemented procedures using an autologous transfusion system got significantly more ABTs than non-cemented procedures using an autologous transfusion system (p=0.0042, odds ratio=2.035).Conclusions Use of an autologous transfusion system did not reduce the amount of ABT in revision THA in the patient cohort reported here. In our opinion, general blood management is required before and during surgery to reduce administration of ABT.

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Section: Introductionmentioning

confidence: 99%

Effectiveness of an autologous transfusion system following cemented and non-cemented revisions of total hip arthroplasty

Hawi

Kendoff

Hessling

et al. 2014

International Orthopaedics (SICOT)

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“…8 Blood products used in surgery increase the transmission risk of hepatitis, human immunodeficiency virus, parvovirus B19 and human T-lymphotropic virus type I and II. 11 Transfusion also increases the risk of allo-immunization, hemolytic and allergic reactions and transfusion-related acute lung injury. 11 Blood transfusions represent significant financial burden to the healthcare system and methods to reduce its use are warranted.…”

Section: Discussionmentioning

confidence: 99%

“…11 Transfusion also increases the risk of allo-immunization, hemolytic and allergic reactions and transfusion-related acute lung injury. 11 Blood transfusions represent significant financial burden to the healthcare system and methods to reduce its use are warranted. The purpose of this survey was to evaluate the opinions and practice patterns regard- …”

Section: Discussionmentioning

confidence: 99%

Blood transfusion and hemostatic agents used during radical cystectomy

Punjani

Lavallée

Momoli

et al. 2013

CUAJ

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“…Autologous blood units procured by acute normovolemic hemodilution are retransfused before the patient leaves the operating room and therefore require no inventory or testing costs. This practice also eliminates the possibility of an administrative error that could lead to a fatal ABO-incompatible blood transfusion, which now approximates the risk of mortality from HIV or hepatitis transmission from blood transfusion 30,31 . Because acute hemodilution and re-infusion are accomplished in the operating room by on-site personnel, the blood procurement and administration costs are minimized, making acute hemodilution the less expensive method of autologous blood procurement.…”

Section: Economic Considerationsmentioning

confidence: 99%

Acute Normovolemic Hemodilution

Goodnough

1999

Transfus Alt Transfus Med

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SUMMARY I Acute normovolemic hemodilution is a point of care method of autologous blood procurement. Acute hemodilution has several inherent advantages over preoperative autologous blood donation: it is inexpensive, does not require testing, and has none of the risks of administrative error or bacterial contamination related to stored blood. The clinical efficacy of acute hemodilution is increasingly apparent. This technique will also serve as a foundation for the use of emerging oxygen carrying solutions.

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Transfusion Medicine — Blood Transfusion

Cited by 817 publications

References 99 publications

Effectiveness of an autologous transfusion system following cemented and non-cemented revisions of total hip arthroplasty

Effectiveness of an autologous transfusion system following cemented and non-cemented revisions of total hip arthroplasty

Blood transfusion and hemostatic agents used during radical cystectomy

Acute Normovolemic Hemodilution

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