Transfusion Medicine. Second of Two Parts. Blood Conservation

Goodnough, Lawrence T.; Brecher, Mark E.; Kantner, M.H.; AuBochon, J.P.

doi:10.1097/00005392-199907000-00112

Cited by 85 publications

(144 citation statements)

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“…It has been calculated that moderate blood losses perioperatively result in lower post-operative haematocrit values in surgical patients who have preoperatively donated autologous blood compared to patients who have not donated autologous blood. 16,17 The present study shows that it is not necessary to collect autologous blood from healthy BM donors before the marrow harvest. The post-donation Hb concentrations do not decrease to levels considered detrimental to healthy persons whether autologous blood is transfused or not.…”

Section: Collection Of Autologous Blood From Bm Donors T Parkkali Et Almentioning

confidence: 65%

Collection of autologous blood for bone marrow donation: how useful is it?

Parkkali

Juvonen

Volin

et al. 2005

Bone Marrow Transplant

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Summary:The hospital charts of 495 adult bone marrow (BM) donors to adult patients were reviewed to determine how necessary it is to collect autologous blood for marrow donation. An autologous transfusion was given to 79% of the donors. The median total volume of marrow harvested was 900 ml (range 450-1350 ml). The median number of nucleated cells harvested was 3.2 Â 10 8 /kg patient weight (range 0.9-7.4 Â 10 8 /kg patient weight). On the morning following the harvest, the median haemoglobin (Hb) concentrations were

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Section: Collection Of Autologous Blood From Bm Donors T Parkkali Et Almentioning

confidence: 65%

Collection of autologous blood for bone marrow donation: how useful is it?

Parkkali

Juvonen

Volin

et al. 2005

Bone Marrow Transplant

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“…25 These alternatives need further study to determine their true risks and benefits. This study has several limitations.…”

Section: Discussionmentioning

confidence: 99%

Blood Transfusion and In-hospital Outcomes in Anemic Patients with Myocardial Infarction Undergoing Percutaneous Coronary Intervention

Jani

Smith

et al. 2007

Clin Cardiol

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SummaryStudies have shown poor prognostic implications of anemia in patients with myocardial infarction (MI) and in patients undergoing percutaneous coronary intervention (PCI). The impact of blood transfusion in these populations remains controversial. The objective of this study was to examine the effect of transfusion on in-hospital mortality in anemic patients undergoing PCI for MI.Data from 67,051 PCIs (June 1, 1997 to January 31, 2004) were prospectively collected in a multicenter registry (Blue Cross Blue Shield of Michigan Cardiovascular Consortium). Of these, 4,623 patients who were classified as anemic according to the World Health Organization criteria underwent PCI within 7 days of presentation with acute MI. A propensity score for being transfused was estimated for each patient, and propensity matching and a prediction model for in-hospital death were developed.The average age was 67.8 years, 57.7% of patients were men, and 22.3% of patients received a transfusion during hospitalization. Transfused patients, compared to nontransfused patients, were more likely to be older, female, have lower preprocedure hemoglobin levels, more comorbidities, and a higher unadjusted in-hospital mortality rate (14.52% vs. 3.01%, p < 0.0001). After adjustment for comorbidities and propensity for transfusion, blood transfusion was associated with a higher risk of in-hospital mortality (adjusted odds ratio = 2.02, 95% confidence interval 1.47-2.79, p < 0.0001).In anemic patients undergoing PCI for MI, transfusion was associated with an increased crude and adjusted rate of in-hospital mortality. A randomized controlled trial is needed to determine the value of transfusion and the ideal transfusion criteria.

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“…The efficacy of intraoperative cell salvage techniques and ultra-filtration remain controversial in cardiac surgery. 17,18 Therefore, their use was restricted to very specific situations associated with expected high blood losses or a high priming volume. Although the cell saver was used more frequently and ultra-filtration less so, these techniques were employed in only 20% of the patients.…”

Section: The Blood Conservation Programmentioning

confidence: 99%