Transfusion of intra‐operative autologous whole blood: Influence on complement activation and interleukin formation

Abstract

Inflammatory mediators and plasma haemoglobin were increased in intra-operatively salvaged and filtered blood compared to circulatory levels. Intra-operative retransfusion of autologous whole blood caused a transient systemic increase that normalized in the early postoperative period. There were no significant adverse events reported in the study. These data suggest that the Sangvia(®) system can be used for intra-operative collection and retransfusion of salvaged blood.

Postoperative autologous blood transfusion drain or no drain in primary total hip arthroplasty? A randomised controlled trial

“…One of the advantages of autologous retransfusion is the good quality and the direct contribution of the retransfused red blood cells to oxygen transport, delivery and consumption in the patient [20][21][22][23][24]. This is in contrast to red blood cells in homologous transfusions from a blood bank, in which optimal contribution to the oxygen consumption may take several hours because of so-called storage lesions [25,26].…”

Influence of Autologous and Homologous Blood Transfusion on Interleukins and Tumor Necrosis Factor-α in Peri-operative Patients with Esophageal Cancer

“…However, blood transfusion-associated immunosuppression may further aggravate the postoperative immunosuppression of cancer patients, which will enable residual and exfoliative tumor cells escape from immunological surveillance, leading to recurrence and distant metastasis of tumors (De Oliveira et al, 2012;Meng et al, 2013). A study found that autologous blood transfusion could improve the postoperative immunological function and protect organs of cancer patients (Han et al, 2011;Stachura et al, 2011). This study mainly detect the dynamic changes of IL-6, IL-8, IL-10 and TNF-α levels before and after operations so as to explore the influence of autologous and homologous blood transfusions on the immunological function of patients with esophagus carcinoma.…”

Autotransfusion: Therapeutic Principles, Efficacy and Risks

“…When blood comes into contact with non-endothelial tissue, due to the activation of the coagulation and complement cascade, platelets and leukocytes are activated and erythrocytes are destroyed (Krohn et al 2001, Sinardi et al 2005, Stachura et al 2010). Aspiration of blood increases this damage by air contact and turbulence.…”

“…Several pore-sized filters are now available on the market. Originally this technique was also used intra-operatively, but because of serious adverse effects during reinfusion it was, until recently, only used for reinfusion of wound blood lost in the postoperative phase (drain blood) (Stachura et al 2010 ). The blood is predominately collected without addition of anticoagulants, because the added anticoagulant is not removed by washing, and anticoagulant other than citrate may cause coagulopathy.…”