Transfusion of Polymorphonuclear Neutrophils in a Premature Infant With Klebsiella Sepsis

Review: Deficiencies in the neutrophil system of newborn infants, and the use of leukocyte transfusions in the treatment of neonatal sepsis

“…The first description of the administration of adult donor granulocytes to a human neonate was that of Laurenti [4] in which a preterm infant with Klebsiella septicemia was transfused with 2 x 1 O l o granulocytes obtained by continuous flow filtration. No adverse sequellae were observed and the patient exhibited clinical improvement.…”

The Effect of Hybridoma Antibody Administration upon Neutrophil Kinetics during Experimental Type III Group B Streptococcal Sepsis

“…The explanation for this phenomenon appears to be complex, involving both an incomplete development of the neutrophil system (8,14,16,23,24) and lack of type-specific antibodies to major bacterial pathogens (2,15,21). It is well recognized that because of these deficiencies, many neonates who contract bacterial sepsis cannot be saved with standard antibiotic therapy alone; therefore, much attention has been paid to additional, adjunctive measures, such as exchange transfusion (3 1,32), neutrophil transfusion (9,10,19,20,33) and plasma/antibody administration (28,30) in order to improve the outcome of these patients.…”

Chemotactic Receptor of Cord Blood Granulocytes to the Synthesized Chemotactic Peptide N-Formyl-Methionyl-Leucyl-Phenylalanine

“…Chemotactic dysfunction of CBG has been clearly defined by many investigators (5,6,7,9,13,18). In CBG, response to varying concentrations of chemotactic factor, however, has not been examined, nor compared to ABG.…”