Transfusion of Predonated Autologous Blood in Elective Cardiac Surgery

Love, Tim R.; Hendren, William G.; O’Keefe, Dennis D.; Daggett, Willard M.

doi:10.1016/s0003-4975(10)60198-1

Cited by 103 publications

(27 citation statements)

References 18 publications

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“…Thus, Love et al 5 reduced allogeneic red cell exposure from 62% to 36% with an average donation of 1.97 units of autologous blood (using an average of 1.7 units) with little difference in the use of other products. In another study, 6 77 of 102 patients donating a mean of 4.1 units autologous blood avoided use of allogeneic blood, compared with 23 of 110 patients not participating in the autologous programme.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, collection of blood from donors with cardiovascular disease does not appear to be accompanied by an increased frequency of adverse reactions. [5][6][7] Autologous donor programmes are more readily accessible to patients in the United States than in Canada, where the blood collection system does not readily provide for appropriate medical supervision at donor clinics and patients with cardiovascular disease are generally excluded. Without the tradition of hospital-based blood donor clinics as in the United States, Canadian hospitals have been unwilling or unable to find the resources to mount widely available systematic autologous blood donor clinics.…”

Section: Cette ~Tude Vise It ~Valuer Les Rosultats De La Raise En Opementioning

confidence: 99%

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Autologous blood donation in support of cardiac surgery: a preliminary report on a hospital-based autologous donor programme

Pinkerton

1994

Can J Anaesth

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Section: Discussionmentioning

confidence: 99%

Section: Cette ~Tude Vise It ~Valuer Les Rosultats De La Raise En Opementioning

confidence: 99%

Autologous blood donation in support of cardiac surgery: a preliminary report on a hospital-based autologous donor programme

Pinkerton

1994

Can J Anaesth

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“…The probability of receiving allogeneic blood decreased from 82% to 27%, and from 69% to 32% in the studies by Owings et al and Dzik et al respectively. 3,4 Thus, autologous blood reduces, but does not completely eliminate 3,5,6 exposure to allogeneic transfusions, especially in patients of small body habitus or with a low predonation hematocrit. 7 In the absence of predonation, determinants of allogeneic blood use during myocardial revascularization have been identified to include preoperative factors such as female sex, age, body weight, preoperative hematocrit and red blood cell volume.…”

Section: Occasional Reviewmentioning

confidence: 99%

Transfusions in patients undergoing cardiac surgery with autologous blood

Hardy

Harel

Bélisle

2000

Can J Anesth/J Can Anesth

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705CAN J ANESTH 2000 / 47: 7 / pp [705][706][707][708][709][710][711] Purpose: Determinants of allogeneic blood use in cardiac surgery include preoperative factors such as female sex, age, body weight, hematocrit and red cell volume. We verified if these variables also predicted the need for allogeneic transfusions when autologous blood is predonated.Methods: Demographic and intraoperative variables, hemoglobin concentrations and transfusion requirements in patients undergoing cardiopulmonary bypass with autologous blood predonation were reviewed. Multivariate logistic regression and RECPAM tree-growing analyses were applied to identify the preoperative predictors of allogeneic transfusion in these patients.Results: Data from 230 patients included in our autologous blood program between 1995 and 1998 were analysed. Patients undergoing complex/reoperative surgical procedures and patients over age 64yr with a low red cell volume (<2070ml) undergoing simple procedures were more likely to require allogeneic red cells. Younger patients with a low red cell volume undergoing simple procedures carried an intermediate risk. Allogeneic transfusion was avoided in 95% of patients undergoing simple procedures when red cell volume $ 2070ml.Conclusions: In our institution, complex/reoperative surgery, low red cell volume and increased age are the main factors associated with the need for allogeneic red cell transfusion despite autologous blood predonation. Knowledge of the factors that limit the effectiveness of predonation with respect to allogeneic blood exposure should help clinicians decide which cardiac surgical patients should be included in autologous blood programs.Objectif : Parmi les déterminants de l'utilisation de sang allogénique en cardiochirurgie, on retrouve des facteurs préopératoires comme le sexe féminin, l'âge, la masse corporelle, l'hématocrite et le volume globulaire. Nous avons voulu vérifier si ces variables prédisaient aussi le besoin de transfusions allogéniques dans les cas d'un don autologue préopératoire. Méthode : Les variables démographiques et peropératoires, les concentrations d'hémoglobine et les conditions de transfusion ont été révisées chez des patients qui subissent une circulation extracorporelle avec du sang autologue prélevé avant l'opération. Des analyses de régression logistique multifactorielle et de partition et amalgamation récursive ont été appliquées pour identifier les facteurs prédictifs préopératoires de transfusion allogénique chez ces patients. Résultats : Des données sur 230 patients admis dans notre programme de sang autologue entre 1995 et 1998 ont été analysées. Les patients qui subissent une intervention chirurgicale complexe ou une réopération et ceux qui ont plus de 64 ans, présentent un faible volume globulaire, <2070 ml), et subissent une intervention simple ont davantage besoin de globules rouges allogéniques. Les jeunes patients qui présentent un faible volume globulaire et subissent une opération simple sont moyennement à risque. La transfusion allogénique a été ...

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“…9:~ Cardiac patients appear to behave similarly, with few untoward events related to their cardiac disease. [6][7][8]11 No serious reactions following phlebotomy were apparent in any of the "high-risk" patients donating autologous blood in the study by Mann et al ~2 Nonetheless, close monitoring during and after blood withdrawal by Spiess et al revealed a number of haemodynamic abnormalities, the importance of which is uncertain since these events did not lead to increased morbidity or mortality, l0…”

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confidence: 99%