Transfusion reactions: a comparative observational study of blood components produced before and after implementation of semiautomated production from whole blood

Abstract

The change in manufacturing method was associated with lower reaction rates to SAGM RBCs than to AS-3 RBCs. Pooled BC PLTs were noninferior to random-donor PRP PLTs with respect to ATEs.

Transfusion reactions in pediatric compared with adult patients: a look at rate, reaction type, and associated products

“…This pediatric rate was approximately threefold higher than the adult rate of approximately two per 1000 transfusions. Much of the published data describing rate and frequency of transfusion reactions in adults were obtained from countrywide hemovigilance data and, therefore, do not specifically segregate pediatric from adult data, although these numbers are often referenced as “adult” data since the majority of hospitalized patients are adults . These data reference a range of approximately 2.5 to 3.3 in 1000 .…”

Segments from red blood cell units should not be used for quality testing

“…Units of leukoreduced RBCs in saline‐adenine‐glucose‐mannitol (SAGM) preservative and their corresponding segments (n = 24) were obtained from two CBS centers: London, Ontario; and Calgary, Alberta. The RBC components were produced from WB using one of two production methods: the buffy coat (BC) method or the WB filtration method, with each site providing six BC components and six WB filtration components. For both methods, bags manufactured by Macopharma (Mouvaux, France: LQT7291LX and DQE7291LX) and Fenwal, Inc. (Lake Zurich, IL: CGR6494B and CGR8441B), were used.…”

Process Improvement by Eliminating Mixing of Whole Blood Units after an Overnight Hold Prior to Component Production Using the Buffy Coat Method

“…WB units from each pool were processed into leukoreduced pooled PCs in plasma, leukoreduced RBCs in saline-adenine-glucose-mannitol preservative, and frozen plasma following the standard semiautomated BC production method currently in place at CBS, as described previously [1, 2]. The 4 WB units labeled M were manually and thoroughly mixed prior to the first centrifugation step, while those labeled NM were not.…”

“…At Canadian Blood Services (CBS), production of pooled platelet components (PCs) is a semiautomated process in which WB is held overnight and then separated by a hard centrifugation step into RBCs, plasma, and buffy coats (BCs), from which PCs are subsequently produced [1, 2]. CBS current practice includes a thorough, manual mixing of WB units following the overnight hold immediately prior to the first centrifugation step.…”