Transfusion‐related acute lung injury and potential risk factors among the inpatient <scp>US</scp> elderly as recorded in <scp>M</scp>edicare claims data, during 2007 through 2011

Menis, Mikhail; Anderson, Steven A.; Forshee, Richard A.; McKean, Stephen; Johnson, Chris; Warnock, Rob; Gondalia, Rahul; Mintz, Paul D.; Holness, Leslie; Worrall, Chris; Kelman, Jeffrey A.; Izurieta, Héctor S.

doi:10.1111/trf.12626

Cited by 40 publications

(46 citation statements)

References 60 publications

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“…[38][39][40][41][42] Several mechanisms are thought to be responsible for the association between transfusion and adverse outcomes including transfusion-induced immunomodulation or immunosuppression. 8,[43][44][45][46] While a causal relationship between transfusion and worse outcomes likely exists, the negative outcomes noted after transfusion may also be due, in part, to confounding. Patients who need a transfusion often have lost more blood and may be Bsicker,^leading to worse outcomes.…”

Section: Discussionmentioning

confidence: 97%

Red Cell Transfusion Triggers and Postoperative Outcomes After Major Surgery

Kim

Spolverato

Lucas

et al. 2015

Journal of Gastrointestinal Surgery

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Section: Discussionmentioning

confidence: 97%

Red Cell Transfusion Triggers and Postoperative Outcomes After Major Surgery

Kim

Spolverato

Lucas

et al. 2015

Journal of Gastrointestinal Surgery

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“…When compared to transfused control subjects, patient-related risk factors included emergency cardiac surgery, mechanical ventilation, hematologic malignancy, and high Acute Physiology and Chronic Health Evaluation II (APACHE II) score. A recent retrospective study showed substantially greater odds of TRALI for older individuals, in females than in males, white population than in non-white population, and in patients with history of post-inflammatory pulmonary fibrosis [21]. The study highlights the importance of the underlying condition of the patients in particular if they underwent prior alloimmunization, such as previous pregnancies, transfusions and bone marrow or organ transplantation.…”

Section: Demographicsmentioning

confidence: 99%

“…The study highlights the importance of the underlying condition of the patients in particular if they underwent prior alloimmunization, such as previous pregnancies, transfusions and bone marrow or organ transplantation. Also, greater number of products transfused (more than 5) is associated with a higher incidence of TRALI [21].…”

Section: Demographicsmentioning

confidence: 99%

“…Most clinical studies of TRALI have been conducted in operating rooms and ICU, in the form of prospective and retrospective case-control data analyses in critically ill patients in many different settings (Table 2) [3][4][5][17][18][19]21,23,25,26]. Koch et al [27] have primarily examined the effects of transfusion on cardiac patients, observing significant increase in respiratory insufficiency and necessity for mechanical ventilation after transfusion of older RBC units [3,27].…”

Section: Clinical Evidencementioning

confidence: 99%

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Storage of Red Blood Cells and Transfusion-Related Acute Lung Injury

Babaev

Pozzi

Hare

et al. 2014

JACCOA

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Transfusion-related acute lung injury (TRALI) is a major complication posttransfusion. A consensus definition of TRALI has been recently established to improve diagnosis but the pathogenesis of TRALI is yet to be understood. Although the antibody-mediated two-hit model of TRALI is the classical narrative, increasing evidence of the probable implications of prolonged storage of blood provides novel mechanisms towards storage lesion-the potentially injurious cellular and biochemical changes that occur in stored red blood cells. Red blood cell-derived lipids and micro vesicles may have been playing an important role in the development of TRALI. This article will provide a brief overview of the current understanding of TRALI and then discuss the implications and the potential mechanisms by which stored red blood cells may lead to TRALI. TRALI is characterized by clinical features that include, but not limited to, dyspnea, tachypnea, respiratory insufficiency, noncardiogenic bilateral pulmonary edema, decreased pulmonary compliance and acute hypoxemia (PaO 2 /FiO 2 <300 mmHg, (Table 1) [13,14]. KeywordsThe incidence of TRALI ranges from 1/5,000-1/1,323 transfusions within the general population and it is the leading cause of transfusion-related death in the United States [15]. Such large range in incidence could be attributed to the relatively unspecific diagnostics tools available for TRALI, past cases of under-diagnosis or misdiagnosis, and the elevated incidence of TRALI within vulnerable populations [14][15][16]. A recent study analyzing the incidence of TRALI in critically ill patients admitted to intensive care unit (ICU) observed that over 5% of all patients who received blood transfusion developed TRALI, which is 50-100 times greater occurrence than in the general hospital population [12,17]. Risk factors related to recipients and donorsThe risk factors of TRALI are highly diverse, among patients DefinitionDiagnostic Parameters TRALIBi-lateral infiltrates with non-cardiogenic pulmonary edema. ARDS appearance within 6hours after transfusion. Hypoxemia: PaO 2 /F i O 2 < 300 mmHg. Potential TRALI Similar to TRALI diagnosis with an additional risk-factor for lung injury/ARDS. Delayed TRALI Diagnostic parameters characteristic of TRALI within 24-72 hours after transfusion.

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“…Although its incidence decreased with modified transfusion practices, TRALI was the leading cause of transfusion-related fatalities in the United States from 2007 through to 2011 (1). Acute pancreatitis-associated lung injury (APALI) is the most common and a severe complication in patients with multisystem organ failure.…”

Section: Introductionmentioning

confidence: 99%

Effect of rapamycin on early stage apoptosis of neutrophils in Sprague-Dawley rats with acute lung injury

Zhu

Yuan

et al. 2017

Biomedical Reports

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Abstract. Transfusion-related acute lung injury (TRALI) is a serious complication characterized by the acute onset of non-cardiogenic pulmonary edema following transfusion of blood products. It is not known whether rapamycin has an effect on TRALI that is caused by blood transfusion. The aim of the present study was to determine the effect of rapamycin on early stage apoptosis of neutrophils in Sprague-Dawley rats with acute lung injury. Animal models of TRALI and acute pancreatitis-associated lung injury (APALI) were prepared using Sprague-Dawley rats and histopathological examination of lung tissues was used to validate acute lung injury models. Peripheral blood neutrophils were isolated and early stage apoptosis of neutrophils was detected by flow cytometry. The animal models of TRALI and APALI were constructed successfully. Early stage apoptosis of neutrophils increased in the TRALI group and decreased in the APALI group (P<0.05), while the apoptosis rates in rapamycin intervention TRALI and APALI groups were not significantly different compared to the rate in the control group (P>0.05). In conclusion, early stage apoptosis of neutrophils in TRALI was different from that in APALI, and rapamycin had a limited protective effect on TRALI and APALI in Sprague-Dawley rats.

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Transfusion‐related acute lung injury and potential risk factors among the inpatient US elderly as recorded in Medicare claims data, during 2007 through 2011

Cited by 40 publications

References 60 publications

Red Cell Transfusion Triggers and Postoperative Outcomes After Major Surgery

Red Cell Transfusion Triggers and Postoperative Outcomes After Major Surgery

Storage of Red Blood Cells and Transfusion-Related Acute Lung Injury

Effect of rapamycin on early stage apoptosis of neutrophils in Sprague-Dawley rats with acute lung injury

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