Transfusion‐related acute lung injury (TRALI) following autologous stem cell transplant for relapsed acute myeloid leukaemia: a case report and review of the literature

Leach,; Vora,; Jones, Jones; Lucas,

doi:10.1046/j.1365-3148.1998.00165.x

Cited by 58 publications

(50 citation statements)

References 28 publications

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“…Serological work up of TRALI patients identified antibodies to a HNA in a number of cases (Yomtovian et al, 1984;Nordhagen et al, 1986;Bux et al, 1996;Leach et al, 1998); a description of HNA antigens and their implication in TRALI has been published previously (Bux, 2005).…”

Section: Antibodies To Human Neutrophil Antigensmentioning

confidence: 99%

The pathogenesis of transfusion‐related acute lung injury (TRALI)

2007

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SummaryIn recent years, transfusion-related acute lung injury (TRALI) has developed from an almost unknown transfusion reaction to the most common cause of transfusion-related major morbidities and fatalities. A clinical definition of TRALI was established in 2004, based on acute respiratory distress, noncardiogenic lung oedema temporal association with transfusion and hypoxaemia. Histological findings reveal lung oedema, capillary leucostasis and neutrophil extravasation. However, the pathogenesis of TRALI remains controversial. Leucocyte antibodies, present in fresh frozen plasma and platelet concentrates from multiparous donors, and neutrophil priming agents released in stored cellular blood components have been considered to be causative. As neutrophils and endothelial cells are pivotal in the pathogenesis of TRALI, a threshold model was established to try to unify the various reported findings on pathogenesis. This model comprises the priming of neutrophils and/or endothelium by the patient's co-morbidity, neutrophil and/or endothelial cell activation by the transfused blood component, and the severity of the TRALI reaction.

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Section: Antibodies To Human Neutrophil Antigensmentioning

confidence: 99%

The pathogenesis of transfusion‐related acute lung injury (TRALI)

2007

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“…6,17,20,39,41,42 TRALI has also been reported in patients requiring transplantation of bone marrow and solid organ; ALI in these patients should be considered an untoward reaction related to the graft or to supportive care. [43][44][45][46][47][48][49][50] Further prospective analyses of patients who have undergone transfusion are required to properly identify patients who are at risk for TRALI.…”

Section: Differential Diagnosismentioning

confidence: 99%

Transfusion-related acute lung injury

Silliman¹,

Ambruso²,

Boshkov³

2005

Blood

395

379

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Transfusion-related acute lung injury (TRALI) is a life-threatening adverse effect of transfusion that is occurring at increasing incidence in the United States and that, in the past 2 reporting years, has been the leading cause of transfusionrelated death. TRALI and acute lung injury (ALI) share a common clinical definition except that TRALI is temporally and mechanistically related to the transfusion of blood/blood components. In prospec

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“…TRALI has been reported following transfusion of plasma-containing blood components [13,[17][18][19][20][21][22][23][24][25]. Estimates of the incidence of TRALI include: 1 in 5000 blood and blood components transfused [17]; 1 in 2000 plasma-containing components [26]; 1 in 7900 units of fresh frozen plasma [27]; 1 in 432 units of whole bloodderived platelet concentrates [18]; and 1 in 1323 blood components transfused [18].…”

Section: Incidencementioning

confidence: 99%

Transfusion‐related acute lung injury: a literature review

Barrett

Kam

2006

Anaesthesia

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SummaryTransfusion-related acute lung injury (TRALI) is a serious and potentially fatal complication of transfusion of blood and blood components. TRALI is under-diagnosed and under-reported because of a lack of awareness. A number of models have been proposed to explain the pathogenesis of TRALI: an antibody mediated model; a two-event biologically active mediator model; and a combined model. TRALI can occur with any type of blood product and can occur with as little as one unit. Its presentation is similar to other forms of acute lung injury and management is predominantly supportive. The main strategy in combating TRALI is prevention both through manipulation of the donor pool and through clinical strategies directed at reducing transfusion of blood products including, but not limited to, evidence-based lower transfusion thresholds.

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Transfusion‐related acute lung injury (TRALI) following autologous stem cell transplant for relapsed acute myeloid leukaemia: a case report and review of the literature

Cited by 58 publications

References 28 publications

The pathogenesis of transfusion‐related acute lung injury (TRALI)

The pathogenesis of transfusion‐related acute lung injury (TRALI)

Transfusion-related acute lung injury

Transfusion‐related acute lung injury: a literature review

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