Transfusion requirements in septic shock patients: a randomized controlled trial

Liberal transfusion strategy improves survival in perioperative but not in critically ill patients. A meta-analysis of randomised trials

“…Twenty-seven trials met the inclusion criteria (Table 1) for a total of 11 021 patients: 17 studies enrolled patients in perioperative settings 10-12 15-18 21-23 27-31 33 34 while 10 trials enrolled patients in critically ill settings. 13 14 19 20 24-26 32 35 36 Within the perioperative setting nine trials were in orthopaedic, 12 17 18 21 22 28-30 34 five in cardiac, 10 15 23 27 33 one in vascular, 16 one in oncology surgery, 11 and one trial in obstetrics. 31 Fourteen trials were multicentre 10 17-20 22 24-26 29 31 32 34 36 with 18 trials including more than 100 10-13 15 18 19 21-23 25 26 30-32 34-36 and two trials more than 1000 patients.…”