Transfusion Status in Liver and Kidney Transplantation Recipients—Results from Nationwide Claims Database

Abstract

Background: This study analyzed the status and trends of transfusion and its associated factors among liver and kidney transplantation recipients. Methods: A total of 10,858 and 16,191 naïve liver or kidney transplantation recipients from 2008 to 2017 were identified through the National Health Insurance Service database. The prescription code for transfusion and the presence, number, and amount of each type of transfusion were noted. The odds ratios and 95% confidence intervals were determined to identify significant differences in transfusion and blood components by liver and kidney transplantation recipient characteristics. Results: In this study, 96.4% of liver recipients and 59.7% of kidney recipients received transfusions related to the transplantation operation, mostly platelet and fresh frozen plasma. Higher perioperative transfusion in women and declining transfusion rates from 2008 to 2017 were observed in both liver and kidney recipients. In liver recipients, the transfusion rate in those who received organs from deceased donors was much higher than that in those who received organs from living donors; however, the mortality rate according to transfusion was higher only in recipients of deceased donor organs. In kidney recipients, a higher mortality rate was observed in those receiving transfusion than that in patients without transfusion. Conclusions: In Korea, the transfusion rates in liver and kidney recipients were relatively higher than those in other countries. Sociodemographic factors, especially sex and year of transplantation, were associated with transfusion in solid organ recipients, possibly as surrogates for other causal clinical factors.

Association between non‐alcoholic fatty liver disease and the risk of dementia: A nationwide cohort study

“…Baseline comorbidities, such as hypertension and diabetes, were defined by the responses to the medical history questionnaire. When the examinees were registered as disabled in the NHIS database, they were defined as having a disability 29 . Information on vital status was obtained by accessing the death certificate database from the National Population Registry of the Korea National Statistical Office.…”

“…When the examinees were registered as disabled in the NHIS database, they were defined as having a disability. 29 Information on vital status was obtained by accessing the death certificate database from the National Population Registry of the Korea National Statistical Office. The death registration was nearly complete, and 98.3% was confirmed by the diagnoses of the physician.…”

Research Priorities for Plasma and Platelet Transfusion Strategies in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding

“…Rationale: Transfusions are common in operative repairs involving vascular anastomosis, especially in solid organ transplants. In a large database study of Korean adults, nearly 96% of liver transplant and 60% of kidney transplant recipients received at least one transfusion, most of which were plasma and/or platelets (37). Intraoperative RBC transfusions have been associated with postoperative thrombosis in general surgeries and in those involving free flaps (38, 39).…”

Experiencia de un hospital privado durante los últimos cinco años en materia de trasplantes

“…8 La sensibilización es uno de los problemas más graves en los receptores de órganos, ya que aumenta el riesgo de rechazo hiperagudo. 9 Varios estudios reportan que el número de transfusiones relacionadas con la cirugía afectan negativamente en la supervivencia tanto de receptores hepáticos como renales. 8,9 En el HAP se han realizado esfuerzos activos por minimizar las transfusiones, que han tenido buenos resultados (Figura 2).…”