Transfusion-Transmitted Babesiosis in Washington State: First Reported Case Caused by a WA1-Type Parasite

Herwaldt, Barbara L.; Kjemtrup, Anne; Conrad, Patricia A.; Barnes, Ralph W.; Wilson, Marianna; McCarthy, Maureen G.; Sayers, Merlyn; Eberhard, Mark L.

doi:10.1086/593812

Cited by 110 publications

(85 citation statements)

References 12 publications

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“…Several cases of transfusion-associated babesiosis have been described, mainly in the United States (to the authors' knowledge, none were from Europe) (167).…”

Section: Other Parasitic Infectionsmentioning

confidence: 92%

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

et al. 2008

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SUMMARY In recent years, the increasing number of donors from different regions of the world is providing a new challenge for the management and selection of suitable donors. This is a worldwide problem in most countries with transplantation programs, especially due to the increase in immigration and international travel. This paper elaborates recommendations regarding the selection criteria for donors from foreign countries who could potentially transmit tropical or geographically restricted infections to solid-organ transplant recipients. For this purpose, an extensive review of the medical literature focusing on viral, fungal, and parasitic infections that could be transmitted during transplantation from donors who have lived or traveled in countries where these infections are endemic has been performed, with special emphasis on tropical and imported infections. The review also includes cases described in the literature as well as risks of transmission during transplantation, microbiological tests available, and recommendations for each infection. A table listing different infectious agents with their geographic distributions and specific recommendations is included.

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“…Several cases of transfusion-associated babesiosis have been described, mainly in the United States (to the authors' knowledge, none were from Europe) (167).…”

Section: Other Parasitic Infectionsmentioning

confidence: 92%

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

et al. 2008

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“…Later reports also described infections with WA1-type organisms, which were acquired via blood transfusion in patients from Washington State (267) (isolates WA2 and WA3) and California (327) (isolates CA5 and CA6). Herwaldt et al (267) PCR amplified sections of the SSU rDNAs from WA2 and WA3, which were found to be identical to each other and to WA1. Kjemtrup , and CA6).…”

Section: Babesia Sppmentioning

confidence: 99%

Importance of Nonenteric Protozoan Infections in Immunocompromised People

et al. 2010

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SUMMARY There are many neglected nonenteric protozoa able to cause serious morbidity and mortality in humans, particularly in the developing world. Diseases caused by certain protozoa are often more severe in the presence of HIV. While information regarding neglected tropical diseases caused by trypanosomatids and Plasmodium is abundant, these protozoa are often not a first consideration in Western countries where they are not endemic. As such, diagnostics may not be available in these regions. Due to global travel and immigration, this has become an increasing problem. Inversely, in certain parts of the world (particularly sub-Saharan Africa), the HIV problem is so severe that diseases like microsporidiosis and toxoplasmosis are common. In Western countries, due to the availability of highly active antiretroviral therapy (HAART), these diseases are infrequently encountered. While free-living amoebae are rarely encountered in a clinical setting, when infections do occur, they are often fatal. Rapid diagnosis and treatment are essential to the survival of patients infected with these organisms. This paper reviews information on the diagnosis and treatment of nonenteric protozoal diseases in immunocompromised people, with a focus on patients infected with HIV. The nonenteric microsporidia, some trypanosomatids, Toxoplasma spp., Neospora spp., some free-living amoebae, Plasmodium spp., and Babesia spp. are discussed.

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“…Gerber et al (11), in a study of patients having undergone cardiothoracic surgery with multiple blood transfusions, noted that the risk of acquiring babesiosis from packed erythrocytes was 0.17%, making it a potential but minor threat to the blood supply. Nevertheless, transmissions are now well-documented in the literature (7,11,17,28,47,55).…”

Section: Babesia and The Blood Supplymentioning

confidence: 99%

“…Like the malaria agent, the parasite attacks and damages host erythrocytes. The disease is transmitted to humans by infected ticks, a route shared with the agents of spotted fever, borreliosis, and ehrlichiosis; human-to-human transmission does not occur with the exception of transfusion-mediated spread (7,17). Babesia is placed in the same taxonomic group-the Piroplasmida-as another blood parasite, Theileria.…”

Section: Introductionmentioning

confidence: 99%

Cultivation ofBabesiaandBabesia-Like Blood Parasites: Agents of an Emerging Zoonotic Disease

Schuster

2002

Clin Microbiol Rev

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Babesia and its close relatives are members of a group of organisms called piroplasms, a name which comes from their pear-shaped outlines. Long associated with blood diseases of cattle and other mammals, members of the genus Babesia have been recognized since the 1950s as infectious agents in humans. Species of this protozoan blood parasite that have routinely been isolated from mice (B. microti) or cattle (B. divergens) have also been isolated from humans. In addition to these familiar species, new isolates that resist being placed in existing taxonomic categories are the basis for rethinking their phylogenetic relationships based on sequencing data. The parasite represents a threat to the safety of the blood supply in that blood from asymptomatic humans can transmit Babesia to blood recipients. Such transmissions have occurred. The development of methods for cultivation of these organisms represents a significant opportunity to study their biology and disease potential. In addition, in vitro cultivation has provided a basis for studying immune responses of mammals to these infectious agents, with the hope of ultimately producing attenuated strains that could be used for immunizing of cattle and, perhaps, humans who live in areas of endemicity. The microaerophilous stationary phase culture technique, which uses a tissue culture medium base supplemented with appropriate serum and erythrocytes, has made it possible to obtain large numbers of parasitized erythrocytes for studying the biology of this parasite

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Transfusion-Transmitted Babesiosis in Washington State: First Reported Case Caused by a WA1-Type Parasite

Cited by 110 publications

References 12 publications

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

Importance of Nonenteric Protozoan Infections in Immunocompromised People

Cultivation ofBabesiaandBabesia-Like Blood Parasites: Agents of an Emerging Zoonotic Disease

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