Transfusion Transmitted Hepatitis: Where Do We Stand Now? A One Center Study in Upper Egypt

El-Faramawy, Amel Abdel Magied; El-Rashidy, Omnia Fathy; Tawfik, Perihan Hamdy; Hussein, Galal Helmy

doi:10.5812/hepatmon.852

Cited by 19 publications

(10 citation statements)

References 25 publications

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“…Likewise, anti-HCV seropositivity in our patients (11.32%) was lower than those reported among multitransfused patients in Jordan (40%), 2 Egypt (45% to 76%), 4 , 15 Iran (44.7%), 16 India (16% to 26%) 5 and Pakistan (51.3%), 17 which is reflected by the relatively lower prevalence (0.95%) of HCV seropositivity among Syrian blood donors. 8…”

Section: Discussioncontrasting

confidence: 70%

Seropositivity of Hepatitis B and C among Syrian Multitransfused Patients

Yazaji

Habbal

Monem

2016

Mediterr J Hematol Infect Dis

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Background and objectivesBlood transfusion is a lifesaving therapy for patients with hemoglobinopathies. However, the need of frequent transfusion carries the risk of transmitting hepatitis B and C infections which are intermediately prevalent in Syria. Despite screening blood donations with sensitive methods, the risk of transmission is still present when infectious blood is donated within the window period. This study aimed to investigate the incidence of HBV and HCV seropositivity, and its association with multiple transfusions among Syrian hemoglobinopathies patients.Materials and MethodsHBsAg, anti-HBc, anti-HBs and anti-HCV were tested for 159 Syrian multi-transfused patients by Enzyme-Linked Immunosorbent Assay (ELISA).ResultsThirty-nine of 159 (24.5%) multi-transfused patients were HBsAg/anti-HBc or anti-HCV positive, 26 (16%) of which never visited the dentist, and they either tested postsurgically negative for HBsAg and anti-HCV or never underwent a surgical procedure. On the contrary of anti-HCV seropositivity, HBsAg/anti-HBc seropositivity was significantly associated with the number of blood transfusions, number of blood units and age (P < 0.001).ConclusionAbout one-sixth of our patients most likely acquired HBV/HCV infection via blood transfusion. Administering HBV vaccine, ensuring the immune status, and monitoring hepatitis markers might considerably minimize the incidence of viral hepatitis among multi-transfused patients.

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Section: Discussioncontrasting

confidence: 70%

Seropositivity of Hepatitis B and C among Syrian Multitransfused Patients

Yazaji

Habbal

Monem

2016

Mediterr J Hematol Infect Dis

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“…The prevalence of HBV infection, here defined as positive HBsAg, among hemophiliacs is lower than that of HCV infection, with different studies finding the prevalence to be 7% - 12% (2, 10, 29-31). However, the rate of positive anti-HBc is much higher (2) (74.6% in our study group).…”

Section: Discussionmentioning

confidence: 98%

Co-Infection of the Hepatitis C Virus With Other Blood-Borne and Hepatotropic Viruses Among Hemophilia Patients in Poland

et al. 2016

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BackgroundThe prevalence of HCV infection in people with hemophilia is substantially higher than that in the general population (63% - 98%). Multiple transfusions and substitutive therapy have also been linked to a high risk of HBV and HIV transmission. However, the prevalence of other blood-borne viral infections in this population is less well known.ObjectivesThis study aimed to assess the prevalence of co-infection with HBV and other blood-borne viruses in Polish HCV-infected hemophiliacs.MethodsSeventy-one individuals, the majority of whom were male (94.36%), who had congenital bleeding disorders (60 had hemophilia A, five had hemophilia B, and six had other factor deficiencies) and HCV infection, which was defined as the presence of positive anti-HCV antibodies, were included in this study. The study group was divided into two subgroups according to the year in which blood donors were first tested for HBsAg in Poland. The serological markers were screened using commercially available enzyme immunoassays according to the manufacturer’s instructions. The molecular tests were performed using real-time PCR technology with commercial assays according to the manufacturer’s instructions.ResultsThe spontaneous elimination rate of HCV RNA was 29.6%. The HCV genotype 1 was detected in 28 patients (65.1%), genotype 2 in one patient (2.3%), genotype 3 in 11 patients (25.6%), genotype 4 in two patients (4.7%), and a mixed infection with genotypes 1 and 4 was detected in one person (2.3%). Fifty-three patients (74.6%) were anti-HBc positive. Among the seven HBsAg(+) patients, three individuals were HBV-DNA positive. No occult hepatitis B was detected. In six HBsAg positive patients, the HCV RNA was positive, while one patient was also infected with HIV. The prevalence rate of past infection with HAV in the study group was 30.9%, with a tendency for a higher prevalence in older patients. The prevalence of CMV and EBV infection was high and similar to that seen in the general population. All the patients were HGV and HTLV-1 negative.ConclusionsThe diagnostics and management of infections with hepatotropic viruses, particularly HBV, are neglected in hemophilic patients. All patients with coagulation disorders and a history of exposure to non-inactivated blood products should be screened for blood-borne infections. The prevalence of other potentially blood-borne viral infections exhibited a pattern similar to that observed in the general population.

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“…Absence of positive HBSAg among studied thalassemic patients was also reported by Amli et al, (2008) [ 3 ] and Omar et al, (2011) [ 8 ]. Hepatitis B virus infection occurred in only one patient (2%) out of 50 thalassemics in the study of El Gawhary et al, (2009) [ 32 ], While in the study of El-Faramawy et al, (2012) [ 9 ] 12% of patients were infected with HBV. The decrease in the prevalence of hepatitis B infection in this study and some other studies reflects the efficacy of the vaccination program and effective screening of blood and blood products for these patients.…”

Section: Discussionmentioning

confidence: 99%

“…Although the risk of post-transfusion hepatitis C virus (HCV) infection dropped significantly after the national screening of blood in 1993, more than 20% of children who were multitransfused after that date were HCV-RNA positive [ 7 ]. In Egypt, prevalence rate of HCV antibodies seropositivity in thalassemic children at 2011was 51.7% [ 8 ] while in the study of El-Faramawy et al, (2012) [ 9 ], a prevalence of 48 % was reported.…”

Section: Introductionmentioning

confidence: 99%

Liver Enzymes in Children with beta-Thalassemia Major: Correlation with Iron Overload and Viral Hepatitis

Salama

Ibrahim²,

Kaddah

et al. 2015

Open Access Maced J Med Sci

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BACKGROUND:Beta Thalassemia is the most common chronic hemolytic anemia in Egypt (85.1%) with an estimated carrier rate of 9-10.2%. Injury to the liver, whether acute or chronic, eventually results in an increase in serum concentrations of Alanine transaminase (ALT) and Aspartate transaminase (AST).AIM:Evaluating the potentiating effect of iron overload & viral hepatitis infection on the liver enzymes.PATIENTS AND METHODS:Eighty (80) thalassemia major patients were studied with respect to liver enzymes, ferritin, transferrin saturation, HBsAg, anti-HCV antibody and HCV-PCR for anti-HCV positive patients.RESULTS:Fifty % of the patients were anti-HCV positive and 55% of them were HCV-PCR positive. Patients with elevated ALT and AST levels had significantly higher mean serum ferritin than those with normal levels. Anti-HCV positive patients had higher mean serum ferritin, serum ALT, AST and GGT levels and higher age and duration of blood transfusion than the negative group. HCV-PCR positive patients had higher mean serum ferritin and serum ALT and also higher age and duration of blood transfusion than the negative group.CONCLUSION:Iron overload is a main leading cause of elevated liver enzymes, and presence of HCV infection is significantly related to the increased iron overload.

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Transfusion Transmitted Hepatitis: Where Do We Stand Now? A One Center Study in Upper Egypt

Cited by 19 publications

References 25 publications

Seropositivity of Hepatitis B and C among Syrian Multitransfused Patients

Seropositivity of Hepatitis B and C among Syrian Multitransfused Patients

Co-Infection of the Hepatitis C Virus With Other Blood-Borne and Hepatotropic Viruses Among Hemophilia Patients in Poland

Liver Enzymes in Children with beta-Thalassemia Major: Correlation with Iron Overload and Viral Hepatitis

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