Transfusion With Preserved Red Blood Cells

Robertson, O. H.

doi:10.1136/bmj.1.2999.691

Cited by 135 publications

(51 citation statements)

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“…When these stored red blood cells were infused back into the donor rabbits, they raised the haematocrit and did not cause haemoglobinuria or bilirubinuria [3]. Two years later, in military hospitals adjacent to World War I battlefields, Rous's post-doctoral fellow, Oswald Robertson, used this solution to store human red blood cells for up to 26 days and used this 'banked' blood to resuscitate soldiers in shock [4,5]. However, Robertson's US Army colleagues became concerned about the possibility of bacterial contamination of the stored blood, and the commission that approved stored blood transfusion for general use approved it only for storage in citrate without glucose and only for 5 days of storage [6].…”

Section: Introductionmentioning

confidence: 99%

Current issues relating to the transfusion of stored red blood cells

Zimrin¹,

2009

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The development of blood storage systems allowed donation and transfusion to be separated in time and space. This separation has permitted the regionalization of donor services with subsequent economies of scale and improvements in the quality and availability of blood products. However, the availability of storage raises the question of how long blood products can and should be stored and how long they are safe and effective. The efficacy of red blood cells was originally measured as the increment in haematocrit and safety began with typing and the effort to reduce the risk of bacterial contamination. Appreciation of a growing list of storage lesions of red blood cells has developed with our increasing understanding of red blood cell physiology and our experience with red blood cell transfusion. However, other than frank haemolysis, rare episodes of bacterial contamination and overgrowth, the reduction of oxygen-carrying capacity associated with the failure of some transfused cells to circulate, and the toxicity of lysophospholipids released from membrane breakdown, storage-induced lesions have not had obvious correlations with safety or efficacy. The safety of red blood cell storage has also been approached in retrospective epidemiologic studies of transfused patients, but the results are frequently biased by the fact that sicker patients are transfused more often and blood banks do not issue blood products in a random order. Several large prospective studies of the safety of stored red blood cells are planned.

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Section: Introductionmentioning

confidence: 99%

Current issues relating to the transfusion of stored red blood cells

Zimrin¹,

2009

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“…Robertson, an English army surgeon, using the solution devised by Rous and Turner, made the first successful use of bank blood during the first World War (4). The solution of Rous and Turner had several serious shortcomings, however, and did not receive general use.…”

Section: Introductionmentioning

confidence: 99%

The in Vitro Preservation and Post-Transfusion Survival of Stored Blood 1

Ross

Finch²,

Peacock³

et al. 1947

J. Clin. Invest.

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“…32 Robertson, who worked with Lee at Harvard and then with Rous and Turner at the Rockefeller, used their storage solution to collect group O whole blood in bottles and then demonstrated the utility of this stored blood as a resuscitation fluid on the battlefields of France in World War I. 33 Mollison has eloquently described the importance of the combination of citrate and glucose, saying that citrate allows the donor and the recipient to be separated in space, whereas glucose allows them to be separated in time. These and more sophisticated storage solutions are the basis for modern RBC banking.…”

Section: Historymentioning

confidence: 99%