Transfusional iron overload presenting as choroid plexus hemosiderosis

Sossa, D. E.; Chiang, Francisco; Verde, Audrey R.; Castillo, Maurício

doi:10.5334/jbr-btr.474

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…However, the pituitary gland could not be evaluated due to susceptibility artifact due to the air of the sphenoid sinus. There have been 2 case reports describing iron deposition in the choroid plexus with the application of SWI, but neither report mentioned imaging findings of the pituitary gland [ [6] , [17] ]. Considering that the sella turcica is surrounded by the air of the sphenoid sinus, SWI may not be suitable for evaluations of the pituitary gland.…”

Section: Discussionmentioning

confidence: 99%

Choroid plexus and pituitary gland hemochromatosis induced by transfusional iron overload: Two case reports

Fujii,

Matsuki,

Hamakawa

et al. 2024

Radiology Case Reports

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Section: Discussionmentioning

confidence: 99%

Choroid plexus and pituitary gland hemochromatosis induced by transfusional iron overload: Two case reports

Fujii,

Matsuki,

Hamakawa

et al. 2024

Radiology Case Reports

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“…Several human diseases of diverse aetiologies have been by now connected to altered iron accumulation in choroid plexuses, such as β-thalassemia, fragile X-associated tremor/ataxia syndrome (FXTAS), haemochromatosis and alcoholism (11)(12)(13)(14)(15)(16). Also, the repeated therapeutic administration of RBC concentrates was related to a so-called "choroid plexus iron overload sign" in magnetic resonance imaging (27,28). Physiologically, iron within the choroid plexus accumulates most pronouncedly within choroid plexus epithelial cells (46)(47)(48)(49), which accordingly express a variety of molecules for iron import, storage and export (21,50).…”

Section: Discussionmentioning

confidence: 99%

“…Alterations in the iron content of choroid plexuses have been observed for diverse human diseases such as β-thalassemia, fragile X-associated tremor/ataxia syndrome (FXTAS), or alcoholism (22)(23)(24)(25)(26). Also, upon repeated therapeutic transfusions of red blood cell (RBC) concentrates or in the genetic iron overload condition hemochromatosis, a "choroid plexus iron overload sign" was described in magnetic resonance imaging (27,28). Thus, accumulation of iron in the choroid plexuses manifests in manifold diseases with diverse aetiologies underscoring the need to further expand the knowledge on iron imbalances at this site.…”

Section: Introductionmentioning

confidence: 99%

Iron accumulation in the choroid plexus, ependymal cells and CNS parenchyma in a rat strain with low‐grade haemolysis of fragile macrocytic red blood cells

et al. 2021

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Iron accumulation in the CNS is associated with many neurological diseases via amplification of inflammation and neurodegeneration. However, experimental studies on iron overload are challenging, since rodents hardly accumulate brain iron in contrast to humans. Here, we studied LEWzizi rats, which present with elevated CNS iron loads, aiming to characterise choroid plexus, ependymal, CSF and CNS parenchymal iron loads in conjunction with altered blood iron parameters and, thus, signifying non-classical entry sites for iron into the CNS. Non-haem iron in formalin-fixed paraffin-embedded tissue was detected via DAB-enhanced Turnbull Blue stainings. CSF iron levels were determined via atomic absorption spectroscopy. Ferroportin and aquaporin-1 expression was visualised using immunohistochemistry. The analysis of red blood cell indices and serum/plasma parameters was based on automated measurements; the fragility of red blood cells was manually determined by the osmotic challenge. Compared with wild-type animals, LEWzizi rats showed strongly increased iron accumulation in choroid plexus epithelial cells as well as in ependymal cells of the ventricle lining. Concurrently, red blood cell macrocytosis, lowgrade haemolysis and significant haemoglobin liberation from red blood cells were apparent in the peripheral blood of LEWzizi rats. Interestingly, elevated iron accumulation was also evident in kidney proximal tubules, which share similarities with the blood-CSF barrier. Our data underscore the importance of iron gateways into the CNS other than the classical route across microvessels in the CNS parenchyma. Our findings of pronounced choroid plexus iron overload in conjunction with peripheral iron overload and increased RBC fragility in LEWzizi rats may be seminal for future studies of human diseases, in which similar constellations are found.

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Transfusional Iron Overload and Choroid Plexus Hemosiderosis in a Pediatric Patient: Brain Magnetic Resonance Imaging Findings

Kim

Lee

Lim

et al. 2019

Investig Magn Reson Imaging

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Transfusional iron overload presenting as choroid plexus hemosiderosis

Cited by 3 publications

References 4 publications

Choroid plexus and pituitary gland hemochromatosis induced by transfusional iron overload: Two case reports

Choroid plexus and pituitary gland hemochromatosis induced by transfusional iron overload: Two case reports

Iron accumulation in the choroid plexus, ependymal cells and CNS parenchyma in a rat strain with low‐grade haemolysis of fragile macrocytic red blood cells

Transfusional Iron Overload and Choroid Plexus Hemosiderosis in a Pediatric Patient: Brain Magnetic Resonance Imaging Findings

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