LETTERS TO THE EDITOR the near-death cortical electrical spike with explosive surges in released dopamine, adenosine, serotonin, and noradrenaline in the frontal and occipital cortices. Interestingly, full patient resuscitation is sometimes achievable even after the cortical isoelectric stage is reached during hypoxia.Thank you, Mashour et al., your study review is fascinating. We can finally possibly understand the perceived outof-body, probably hypoxic, near-end-of-life experiences that people have reported for thousands of years and vividly recall.