Transfusionsmalaria bei Promyelozytenleukämie

Abstract

Five weeks after re-induction treatment and nine days after discharge from hospital, remittent fever occurred in a 34-year-old woman with promyelocytic leukaemia in full remission. She also had haemolytic anaemia and thrombocytopenia, as well as a reduced creatinine clearance. Findings on physical examination were unremarkable, but Falciparum malaria was found in the blood smear. Infusion of erythrocyte or platelet concentrates, administered in treating the leukaemia, was the probable source of the infection. Ten days after starting the administration of chloroquine and sulfadoxine-pyrimethamine she was discharged from hospital, cured of the malaria.

Transfusion-Transmitted Malaria and Mitigation Strategies in Nonendemic Regions

“…In Germany, for example, in the last 40 years, a total of three cases of TTMs have been published. Two of them occurred in the 1980s and the last case in 1997 [ 54 , 55 , 56 ]. In France and England, a total of four cases were registered between 2002 and 2013.…”

Malaria

“…In den letzten 40 Jahren wurden insgesamt drei Fälle von transfusionsassoziierter Malaria in Deutschland veröffentlicht [79][80][81], davon zwei in den 1980er-Jahren sowie der oben bereits beschriebene Fall aus dem Jahr 1997. In Frankreich und England wurden im Zeitraum von 2002 bis 2013 insgesamt vier Fälle registriert; die Spendenden kamen alle aus Westafrika [56].…”

Malaria

“…In the past few years, 3 reports were published on transfusion associated cases of malaria [54][55][56]. In 1998, Witt et al [56] ported on an 18-month-old boy who developed antibiotic refractory fever 14 days after a heart operation.…”