2010
DOI: 10.1038/aja.2009.76
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Transgelin induces apoptosis of human prostate LNCaP cells through its interaction with p53

Abstract: The androgen receptor (AR) and its coregulators have important roles in the carcinogenesis of prostate cancer. p53 is an important tumour suppressor gene, and the absence of a fundamental p53 response may predispose to cancer. Transgelin, known as an ARA54-associated AR inhibitor, can suppress AR function in LNCaP cells. In addition to these effects, we aimed to elucidate the proapoptotic effects of the protein on LNCaP and its underlying mechanisms, especially the interaction between transgelin and p53. Cell … Show more

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Cited by 24 publications
(17 citation statements)
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“…Transgelin acts as a repressor of MMP-9, a crucial protease for metastasis [36]. Transgelin is also reported to interact with p53, induce apoptosis and inhibit AR pathway in prostate cancer cells [37,38]. These studies show possible tumor suppressor activity of transgelin.…”
Section: Resultsmentioning
confidence: 99%
“…Transgelin acts as a repressor of MMP-9, a crucial protease for metastasis [36]. Transgelin is also reported to interact with p53, induce apoptosis and inhibit AR pathway in prostate cancer cells [37,38]. These studies show possible tumor suppressor activity of transgelin.…”
Section: Resultsmentioning
confidence: 99%
“…SM22α has been identified as the first ARA54‐associated negative modulator for androgen receptor in prostate cells [24]. The mitochondria‐associated apoptosis pathway was activated after transfection of SM22α into LNCaP cells and interaction between SM22α and p53 was confirmed by co‐immunoprecipitation in these cells [25]. SM22α has been also suggested as a tumor suppressor.…”
Section: Discussionmentioning
confidence: 99%
“…To detect apoptosis, we performed the terminal deoxynucleotidyl transferase-dUTP nick end labeling (TUNEL) assay (Invitrogen) as described previously. [ 15 ] Briefly, RT4 cells were seeded onto a 60-mm dish containing a coverslip. After treatment, cells were fixed with 4% paraformaldehyde in PBS followed by permeabilization with 0.25% Triton X-100.…”
Section: Ethodsmentioning
confidence: 99%