2005
DOI: 10.1007/s11248-005-4349-y
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Transgene transmission to progeny by oMt1a-oGH transgenic mice

Abstract: Most studies utilizing transgenic technology focus on the impact to traits of interest, rather than propagation of the transgene to offspring. In animals containing growth hormone constructs, transgene transmission to progeny follows a Mendelian pattern of inheritance in the first few generations following generation of a founder animal, but decreases in subsequent generations. In the present study, the ovine metallothionein 1a-ovine growth hormone (oMt1a-oGH) transgenic mouse was used to determine whether tra… Show more

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Cited by 3 publications
(2 citation statements)
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“…Similarly, with regards to the hMT2 mice, it is likely that mutant transgene expression is too low to signficantly disrupt cellular pathways dependent on torsinA. It is possible that transgene repression or inactivation, which has been described in numerous plant and animal models is responsible for the Northern blot and QRT-PCR results seen in hWT and hMT2 mice (Kilby et al, 1992;Chevalier-Mariette et al, 2003;Thomas et al 2005). DNA methylation, which may occur over several generations, appears to be the most common mechanism of transgene repression/inactivation.…”
Section: Discussionmentioning
confidence: 99%
“…Similarly, with regards to the hMT2 mice, it is likely that mutant transgene expression is too low to signficantly disrupt cellular pathways dependent on torsinA. It is possible that transgene repression or inactivation, which has been described in numerous plant and animal models is responsible for the Northern blot and QRT-PCR results seen in hWT and hMT2 mice (Kilby et al, 1992;Chevalier-Mariette et al, 2003;Thomas et al 2005). DNA methylation, which may occur over several generations, appears to be the most common mechanism of transgene repression/inactivation.…”
Section: Discussionmentioning
confidence: 99%
“…Similarly, with regards to the hMT2 mice, it is likely that mutant transgene expression is too low to significantly disrupt cellular pathways that are dependent on torsinA. It is possible that transgene repression or inactivation, which has been described in numerous plant and animal models, is responsible for the Northern blot and QRT-PCR results seen in hWT and hMT2 mice (Kilby et al, 1992;ChevalierMariette et al, 2003;Thomas et al 2005). DNA methylation, which might occur over several generations, appears to be the most common mechanism of transgene repression/inactivation.…”
Section: Discussionmentioning
confidence: 99%