Transgeneration Effects of Antenatal Acute Hypoxia during Early Organogenesis

Dunaeva, T. Yu.; Trofimova, L. K.; Граф, А. В.; Maslova, M. V.; Маклакова, А. С.; Krushinskaya, Ya. V.; Sokolova, N. A.

doi:10.1007/s10517-009-0316-6

Cited by 4 publications

(4 citation statements)

References 4 publications

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“…Mammalian studies have shown that prenatal exposure to certain environmental stresses (e.g., hypoxia) and chemical contaminants (e.g., endocrine disrupting chemicals) can lead to alterations in phenotypes (e.g., delayed physical and sexual development, infertility, increased mortality and behavioral changes) in successive generations, despite the offspring have never been directly exposed to the stress and contaminants before [11] , [12] . Such transgenerational effects may not be caused by alterations in DNA sequence but by changes in the epigenome.…”

Section: Introductionmentioning

confidence: 99%

Identification and Expression Profiling of MicroRNAs in the Brain, Liver and Gonads of Marine Medaka (Oryzias melastigma) and in Response to Hypoxia

et al. 2014

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The marine medaka (Oryzias melastigma) has been increasingly used as a fish model for detecting environmental stresses and chemical contaminants in the marine environment. Recent mammalian studies have shown that environmental stresses can alter the expression profiles of microRNAs (miRNAs), leading to transgenerational effects. Here, we use high-throughput Illumina RNA sequencing (RNA-Seq) for miRNA transcriptome analysis of brain, liver, and gonads from sexually mature male and female marine medaka. A total of 128,883,806 filtered sequence reads were generated from six small RNA libraries, identifying a total of 2,125,663 non-redundant sequences. These sequences were aligned and annotated to known animal miRNAs (miRBase) using the BLAST method. A total of 223 distinct miRNA types were identified, with the greatest number expressed in brain tissue. Our data suggested that 55 miRNA types from 34 families are common to all tested tissues, while some of the miRNAs are tissue-enriched or sex-enriched. Quantitative real-time PCR analysis further demonstrated that let-7a, miR-122, and miR-9-3p were downregulated in hypoxic female medaka, while miR-2184 was specifically upregulated in the testis of hypoxic male fish. This is the first study to identify miRNAs in O. melastigma using small RNA deep sequencing technology. Because miRNA expression is highly conserved between marine medaka and other vertebrates, marine medaka may serve as a good model for studies on the functional roles of miRNAs in hypoxia stress response and signaling in marine fish.

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Section: Introductionmentioning

confidence: 99%

Identification and Expression Profiling of MicroRNAs in the Brain, Liver and Gonads of Marine Medaka (Oryzias melastigma) and in Response to Hypoxia

et al. 2014

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“…Owing to this, we tested if SP would show a protective action on the behavioral and biochemical changes induced by hypoxia. We used the previously established model, in which acute hypoxia was created in a decompression chamber with female rats sensitized to the insult by pregnancy [21, 24, 31]. Protective action of SP was observed already during the acute hypoxia in decompression chamber.…”

Section: Resultsmentioning

confidence: 99%

Behavioral Impact of the Regulation of the Brain 2-Oxoglutarate Dehydrogenase Complex by Synthetic Phosphonate Analog of 2-Oxoglutarate: Implications into the Role of the Complex in Neurodegenerative Diseases

Trofimova

Lovat

Groznaya

et al. 2010

International Journal of Alzheimer's Disease

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Decreased activity of the mitochondrial 2-oxoglutarate dehydrogenase complex (OGDHC) in brain accompanies neurodegenerative diseases. To reveal molecular mechanisms of this association, we treated rats with a specific inhibitor of OGDHC, succinyl phosphonate, or exposed them to hypoxic stress. In males treated with succinyl phosphonate and in pregnancy-sensitized females experiencing acute hypobaric hypoxia, we revealed upregulation of brain OGDHC (within 24 hours), with the activity increase presumably representing the compensatory response of brain to the OGDHC inhibition. This up-regulation of brain OGDHC was accompanied by an increase in exploratory activity and a decrease in anxiety of the experimental animals. Remarkably, the hypoxia-induced elevation of brain OGDHC and most of the associated behavioral changes were abrogated by succinyl phosphonate. The antagonistic action of hypoxia and succinyl phosphonate demonstrates potential therapeutic significance of the OGDHC regulation by the phosphonate analogs of 2-oxoglutarate.

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“…221 Subsequently, environment hypoxia resulted transgenerational task was detected in rats. 222 Intriguingly, breakthrough finding was reported in fish that hypoxia impairs male reproduction in Oryzias melastigma by declining of spermatozoa quality and quantity, via the methylation regulation. 73,223 Probing the mechanism of hypoxic stress on fish physiology through methylation is being emphasized, including reproductive impairments, 73,223,224 embryogenesis, 225 immunity, 226 growth and development 227 and metabolism.…”

Section: Hypoxic Stressmentioning

confidence: 99%

“…Earlier, the studies reported that exposing monkeys to high altitude with hypoxic stress significantly changed number of spermatozoa and spermatozoa motility 221 . Subsequently, environment hypoxia resulted transgenerational task was detected in rats 222 . Intriguingly, breakthrough finding was reported in fish that hypoxia impairs male reproduction in Oryzias melastigma by declining of spermatozoa quality and quantity, via the methylation regulation 73,223 .…”

Section: Identification Of Dna Methylation Changes In Fish Spermatozo...mentioning

confidence: 99%

Potential implications of sperm DNA methylation functional properties in aquaculture management

Zhang

Cheng

Vechtova

et al. 2022

Reviews in Aquaculture

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The biology of fish sperm, an important topic in the research of reproduction and fisheries from basic science to evolutionary and applied aspects, has implications for aquaculture management, fish breeding and biological conservation. The quality of spermatozoa plays a vital role in fish fertility, and directly affects the health and performance of offspring. Environmental factors that affect determinants of spermatozoa quality usually reflected in the DNA methylation pattern of the spermatozoa epigenome, which may change offspring's performance. The aim of the present study was to conduct a review on existing data about DNA methylation in fish spermatozoa as a biological tool for identifying the quality of offspring based on their phenotypes and performances. Furthermore, this study provides valuable knowledge from fundamental to applied sciences dealing with enhancement of breeding selection, fish reproduction and environmental adaptation. The review also describes the individual

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Transgeneration Effects of Antenatal Acute Hypoxia during Early Organogenesis

Cited by 4 publications

References 4 publications

Identification and Expression Profiling of MicroRNAs in the Brain, Liver and Gonads of Marine Medaka (Oryzias melastigma) and in Response to Hypoxia

Identification and Expression Profiling of MicroRNAs in the Brain, Liver and Gonads of Marine Medaka (Oryzias melastigma) and in Response to Hypoxia

Behavioral Impact of the Regulation of the Brain 2-Oxoglutarate Dehydrogenase Complex by Synthetic Phosphonate Analog of 2-Oxoglutarate: Implications into the Role of the Complex in Neurodegenerative Diseases

Potential implications of sperm DNA methylation functional properties in aquaculture management

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