Transgenerational Effects of Two Antidepressants (Sertraline and Venlafaxine) on <i>Daphnia magna</i> Life History Traits

Minguez, Laëtitia; Ballandonne, Céline; Rakotomalala, Christiane; Dubreule, Christelle; Kientz-Bouchart, Valérie; Halm-Lemeille, Marie-Pierre

doi:10.1021/es504808g

Cited by 65 publications

(23 citation statements)

References 49 publications

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“…Although no differences in patterns were observed for energy reserves within generations and exposures to carbendazim, a trade‐off seemed to have occurred that can be seen by examining r and the longevity of an organism. Several authors have reported that D. magna had the ability to switch life history responses under exposure to stressors (Minguez et al ), and in the present study reproduction was found to be more favored than survival. Different patterns may be explained by the nature of a chemical, but the level of concentration used should also be considered.…”

Section: Resultssupporting

confidence: 65%

Multigenerational effects of carbendazim in Daphnia magna: From a subcellular to a population level

Silva

Santos

Ferreira

et al. 2019

Enviro Toxic and Chemistry

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Anthropogenic activities such as the use of pesticides may affect aquatic biota populations, due to potential agricultural runoffs or disposals. Carbendazim is one example of a widely used fungicide with a high potential to end up in aquatic ecosystems through runoff. Deleterious effects observed at the individual level are possibly explained by changes in homeostasis at the cellular level, and both factors can then be used to predict effects at the population level. In the present study, an isoclonal population of Daphnia magna (clone K6) was exposed to a concentration that mimics relevant levels of carbendazim in the environment over 12 generations. The effects of carbendazim were assessed in some generations using the following endpoints: biochemical biomarkers (cholinesterase, catalase, and glutathione-S-transferase), lipid peroxidation and energy-related parameters (carbohydrates, lipids, and proteins along with available energy and energy consumption), parental longevity, and population growth (r). Long-term exposure to carbendazim had no effect on the intrinsic rate of natural increase (r) of adult D. magna, but longevity was decreased at the F12 generation compared to that of control. Differences between the exposed and nonexposed populations were found for cholinesterase, glutathione-S-transferase, and lipid peroxidation. However, for catalase and energy-related parameters, no differences were observed between these 2 populations. Natural variability was seen throughout the test period, under control conditions, within the 12 generations. Overall, carbendazim induced some effects at the subcellular level that translated into changes in longevity but these later vanished in terms of population effects. Environ Toxicol Chem 2019;38:412-422. C 2018 SETAC

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Section: Resultssupporting

confidence: 65%

Multigenerational effects of carbendazim in Daphnia magna: From a subcellular to a population level

Silva

Santos

Ferreira

et al. 2019

Enviro Toxic and Chemistry

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“…Hence, the modifications of energy allocation observed in F2 organisms (i.e., earlier puberty and reduction of egg reserves) translated in a lower growth ability of F3 offspring. Such cross generation trade-offs were previously reported in Gammarus [61], in Daphnia [62], and in the oyster Saccostrea glomerate [63], where a decrease in the amount of energy allocated to eggs due to direct exposure to contaminant led to smaller offspring. Therefore, we might describe here a cascading model of changes in the life-history traits of G. fossarum that originates from a reduction of F1 brood size, which then has resulted in an increased energy allocation to reproduction in F2 females, and then a reduced growth in F3 juveniles.…”

Section: Cascading Effects On F1 F2 Reproductive Features and F3 Grosupporting

confidence: 70%

A “Population Dynamics” Perspective on the Delayed Life-History Effects of Environmental Contaminations: An Illustration with a Preliminary Study of Cadmium Transgenerational Effects over Three Generations in the Crustacean Gammarus

Cribiu

Devaux

Garnero

et al. 2020

IJMS

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We explore the delayed consequences of parental exposure to environmentally relevant cadmium concentrations on the life-history traits throughout generations of the freshwater crustacean Gammarus fossarum. We report the preliminary results obtained during a challenging one-year laboratory experiment in this environmental species and propose the use of population modeling to interpret the changes in offspring life-history traits regarding their potential demographic impacts. The main outcome of this first long-term transgenerational assay is that the exposure of spawners during a single gametogenesis cycle (3 weeks) could result in severe cascading effects on the life-history traits along three unexposed offspring generations (one year). Indeed, we observed a decrease in F1 reproductive success, an early onset of F2 offspring puberty with reduced investment in egg yolk reserves, and finally a decrease in the growth rate of F3 juveniles. However, the analysis of these major transgenerational effects by means of a Lefkovitch matrix population model revealed only weak demographic impacts. Population compensatory processes mitigating the demographic consequences of parental exposure seem to drive the modification of life-history traits in offspring generations. This exploratory study sheds light on the role of population mechanisms involved in the demographic regulation of the delayed effects of environmental toxicity in wild populations.

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“…The relatively high concentration (∼50 μg L −1 ) of venlafaxine caused significant effects in the F 0 and 18S rRNA gene expression, indicating that algae could be the most concerned (without discarding protozoa or fungi). This chemical has an up to now unknown mode of action on algae, though it acts as a serotonin–norepinephrine reuptake inhibitor and affects the reproduction and metabolism of cladocerans and fish ( Henry et al, 2004 ; Galus et al, 2013 ; Minguez et al, 2015 ). On the other hand, diuron inhibits algal photosynthesis by blocking the electron transfer at PSII ( Kumar et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Fullerenes Influence the Toxicity of Organic Micro-Contaminants to River Biofilms

et al. 2018

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Organic micro-contaminants (OMCs) enter in freshwaters and interact with other contaminants such as carbon nanoparticles, becoming a problem of unknown consequences for river ecosystems. Carbon nanoparticles (as fullerenes C60) are good adsorbents of organic contaminants and their interaction can potentially affect their toxicity to river biofilms. We tested the C60 interactions with selected OMCs and their effects on river biofilms in different short-term experiments. In these, river biofilms were exposed to C60 and three OMCs (triclosan, diuron, or venlafaxine) and their respective mixtures with fullerenes (C60 + each OMC). The effects were evaluated on structural, molecular, and functional descriptors of river biofilms. Our results showed that C60 did not cause toxic effects in river biofilms, whereas diuron and triclosan significantly affected the heterotrophic and phototrophic components of biofilms and venlafaxine affected only the phototrophic component. The joint exposure of C60 with venlafaxine was not producing differences with respect to the former response of the toxicant, but the overall response was antagonistic (i.e., decreased toxicity) with diuron, and synergistic (i.e., increased toxicity) with triclosan. We suggest that differences in the toxic responses could be related to the respective molecular structure of each OMC, to the concentration proportion between OMC and C60, and to the possible competition between C60 pollutants on blocking the receptors of the biological cell membranes. We conclude that the presence of C60 at low concentrations modified the toxicity of OMC to river biofilms. These interactions should therefore be considered when predicting toxicity of OMC in river ecosystems.

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Transgenerational Effects of Two Antidepressants (Sertraline and Venlafaxine) on Daphnia magna Life History Traits

Cited by 65 publications

References 49 publications

Multigenerational effects of carbendazim in Daphnia magna: From a subcellular to a population level

Multigenerational effects of carbendazim in Daphnia magna: From a subcellular to a population level

A “Population Dynamics” Perspective on the Delayed Life-History Effects of Environmental Contaminations: An Illustration with a Preliminary Study of Cadmium Transgenerational Effects over Three Generations in the Crustacean Gammarus

Fullerenes Influence the Toxicity of Organic Micro-Contaminants to River Biofilms

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