Transgenerational Studies: How Do We Investigate Multigenerational Effects?

Harville, Emily W.; Kartiosuo, Noora

doi:10.1002/oby.22723

Cited by 2 publications

(4 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, evidence suggests that maternal obesity has also persistent long‐term health effects in offspring 8,15 . In the same sense, the case of grandmother GWG does not only affect pregnancy outcomes but may also have persistent effects on offspring and grandchildren BMI 16‐18 . We showed that the G2 GWG increased the chances of G3 over 2 years of age being overweight, as the literature has already shown 8,11 .…”

Section: Discussionsupporting

confidence: 67%

“…8,15 In the same sense, the case of grandmother GWG does not only affect pregnancy outcomes but may also have persistent effects on offspring and grandchildren BMI. [16][17][18] We showed that the G2 GWG increased the chances of G3 over 2 years of age being overweight, as the literature has already shown. 8,11 respectively], when compared to adequate GWG.…”

Section: Refsupporting

confidence: 64%

“…The foetal over‐nutrition hypothesis claims that increased foetal exposure to nutrients (particularly glucose, lipids, and amino acids) may lead to persistent adaptations in the structure and function of adipose tissue (increased expression of adipogenesis, lipogenesis, and adipokine genes) and to the regulation of appetite and energy metabolism, leading to greater susceptibility to obesity at later ages 13‐15 . However, it is unclear whether intrauterine programming continues in a third generation nor if it occurs directly via epigenetic information from the gametes or indirectly via intrauterine exposures in generation two 15‐17 . A Scottish study with 1457 grandmother‐mother‐grandchild triads concluded that grandmother birthweight was associated with grandchild birthweight, independently of maternal birthweight 18 …”

Section: Introductionmentioning

confidence: 99%

“…[13][14][15] However, it is unclear whether intrauterine programming continues in a third generation nor if it occurs directly via epigenetic information from the gametes or indirectly via intrauterine exposures in generation two. [15][16][17] A Scottish study with 1457 grandmother-mother-grandchild triads concluded that grandmother birthweight was associated with grandchild birthweight, independently of maternal birthweight. 18 There is a paucity of studies assessing intergenerational health effects in the literature, since long-term follow-ups from participants are required.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Gestational weight gain and childhood body mass index across three generations: Results from the 1993 Pelotas (Brazil) Birth Cohort

et al. 2021

View full text Add to dashboard Cite

Summary Background Gestational weight gain (GWG) has been associated with the accumulation of body fat in offspring, but little is known about the intergenerational relationship. Objective To assess the effect of GWG in grandmothers and mothers on the child's body mass index (BMI). Methods This is a sub‐study nested in the 1993 Pelotas (Brazil) Birth Cohort at 22 years follow‐up visit. We calculated the BMI‐for‐age z‐score (BAZ) and evaluated overweight (>2 SD in ≤5 years of age and >1 SD for >5 years of age for BAZ). Grandmothers' and mothers' GWG were calculated as the difference between weight in the beginning of pregnancy and the last recorded weight before delivery. We standardized the GWG by adjusting for pre‐gestational BMI. We also categorized GWG as adequate, excessive, or insufficient, in accordance with the Institute of Medicine (2009). Linear and logistic regressions stratified by child's age (≤2 years; 2.01‐5 years; >5 years) were used. Structural equations were modelled to calculate the total, indirect, and direct effects of grandmothers' and mothers' GWG on children's BAZ. Results Nine hundred and forty‐six out of 1113 children evaluated were 5 years of age or under. There was an indirect effect (through maternal birthweight, maternal pre‐gestational BMI, maternal GWG, and child birthweight) of grandmother GWG on grandchild BAZ, from 2.01 to 5 years of age [β = 0.12 95%CI: 0.04‐0.20 (P < 0.01)]. Maternal GWG directly increased the child's BAZ at >5 years of age [β = 0.34 95%CI: 0.15‐0.53 (P < 0.001)]. Conclusions GWG's effect on BMI does seem to be transmitted across three generations. Managing this will require health education during the gestational period for women and their families.

show abstract

Section: Discussionsupporting

confidence: 67%