Transgenic Expression of Leukemia Inhibitory Factor Inhibits Both Rod and Cone Gene Expression

Ash, John D.; Graham, D.R.

doi:10.1007/0-387-32442-9_22

Cited by 1 publication

(2 citation statements)

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“…As previously reported, LIF profoundly inhibited photoreceptor maturation, including the development of the light‐sensitive rod outer segments and the expression of cone opsins (Ash and Graham, 2005; Graham et al, 2005). To characterize further the effects on rods and cones, we analyzed retinas for the expression of recoverin and peanut agglutinin (PNA; Fig.…”

Section: Resultssupporting

confidence: 70%

“…1C,D). However, these cells were arrested in an immature state, showing little or no outer segment and a short inner segment, and they did not express opsin (Ash and Graham, 2005; Graham et al, 2005). Another major effect of LIF on photoreceptor development was perturbed synaptic development, as shown by the patchy structure of the outer plexiform layer (OPL) and the aberrant spacing of putative cone terminals in the OPL and their growth into the inner nuclear layer (INL) or inner plexiform layers (IPL).…”

Section: Resultsmentioning

confidence: 99%

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Leukemia inhibitory factor inhibits neuronal development and disrupts synaptic organization in the mouse retina

Sherry¹,

Mitchell²,

Li³

et al. 2005

J. Neurosci. Res.

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Leukemia inhibitory factor (LIF) belongs to the interleukin-6 cytokine family, all members of which signal through the common gp130 receptor. Neurotrophic members of this cytokine family are known to arrest photoreceptor maturation and are likely to regulate maturation of other retinal neurons as well. We have used transgenic mice that constitutively express LIF beginning in embryonic development to determine its effects on synaptic organization and molecular maturation of all classes of retinal neurons. LIF reduced the numbers of cells showing markers characteristic of mature cells of all neuronal classes and caused synaptic ectopia. The net effect was disrupted morphological development and disturbed synaptic organization. Our study suggests that cytokines signaling through gp130 are capable of regulating many aspects of neuronal differentiation in the retina, including synaptic targeting.

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Section: Resultssupporting

confidence: 70%

Section: Resultsmentioning

confidence: 99%