“…In particular, the neurotrophin-3 receptor gene (NTRK3, MIM#191316) is highly expressed in the locus coeruleus [King, et al, 1999], a brain structure that has an important function in the fear/alarm modulatory circuitry [Sullivan, et al, 1999]. Furthermore, overexpression of a full length isoform of 4 NTRK3 has been shown to contribute to anxiety-like behaviour in NTRK3 transgenic mice, whose anxious phenotype was reversed by the administration of benzodiazepines [Dierssen, et al, 2006;. Linkage and association studies suggest NTRK3 as a candidate gene also for other psychiatric disorders such as eating disorders or major depression [Camp, et al, 2005;Holmans, et al, 2007;Verma, et al, 2008].…”