Transgenic overexpression of a dominant negative mutant of FADD that, although counterselected during tumor progression, cooperates in L‐myc‐induced tumorigenesis
Abstract:Key words: FADD-DN; death receptor; cell cycle; oncogene cooperationApoptosis as a special form of programmed cell death has been recognized as a fundamental process both throughout embryogenesis and in the adult organism to maintain tissue homeostasis and remove dangerous or surplus cells without inflammation. 1 For a cancer to occur and progress, apoptosis must be inhibited as the tumor cells are constantly exposed to a variety of apoptotic stimuli, e.g., overexpression of apoptosis-inducing oncogenes, hypox… Show more
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