Transgressive segregation of primary and secondary metabolites in F2 hybrids between Jacobaea aquatica and J. vulgaris

Kirk, Heather; Cheng, Dandan; Choi, Young Hae; Vrieling, Klaas; Klinkhamer, Peter G. L.

doi:10.1007/s11306-011-0301-8

Cited by 24 publications

(19 citation statements)

References 30 publications

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“…As a consequence, novel combinations, extreme concentrations of secondary metabolites, or in some cases, metabolites not found in both parents are expressed as a result of sexual reproduction. Indeed, several studies focusing on the impact of hybridization among related plant species on metabolomic profiles in their progeny support this hypothesis (Kirk et al 2004(Kirk et al , 2005(Kirk et al , 2012.…”

Section: Genomic Variation As Raw Materials For Metabolic Innovationmentioning

confidence: 94%

The Remarkable Pliability and Promiscuity of Specialized Metabolism

Weng

Noel

2012

Cold Spring Harbor Symposia on Quantitative Biology

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Metabolic pathways are often considered "perfected" or at least predictable as substrates efficiently rearrange into products through the intervention of an optimized enzyme. Moreover, single catalytic steps link up, forming a myriad of metabolic circuits that are often modeled with a high degree of certainty. However, on closer examination, most enzymes are not precise with respect to their activity, using not just one substrate but often a variety and producing not just one product but a diversity. Hence, the metabolic systems assembled from enzymes possessing varying degrees of what can be termed catalytic promiscuity are not clear-cut and restrictive; rather, they may at times operate stochastically in the intracellular milieu. This "messiness" complicates our understanding of normal and aberrant cellular behavior, while paradoxically sowing the seeds for future advantageous metabolic adaptations for host organisms. Catalytic promiscuity is intrinsically associated with the dynamic nature of enzyme structures and their chemical mechanisms, both key to enzyme and metabolic evolvability. In addition to primary (core) metabolism, which is essential for survival, organisms also possess highly elaborated secondary (specialized) metabolic systems. These specialized enzymes and pathways often provide unique adaptive strategies for a myriad of organisms and their populations in challenging and changing ecosystems. Generally, enzymes of specialized metabolism show attenuated kinetic activities and expanded catalytic promiscuity compared with their phylogenetic relatives rooted in primary metabolism. We propose that evolvability may be a selected trait in many specialized metabolic systems spread across populations of organisms exposed to continually fluctuating biotic and abiotic environmental pressures. As minor metabolites arising from catalytic messiness provided enhanced population fitness, specificity relaxed, and catalytic efficiency was attenuated. This updated view provides a mechanistic basis for reaching a deeper understanding of the evolutionary underpinnings of the explosion of chemodiversity in nature.Fundamentally, metabolism is a chemical property of living organisms, defined as the collection of enzymecatalyzed chemical reactions that synthesize or deconstruct metabolic chemicals necessary to sustain life and contribute to the reproductive success of host populations in the face of ever-changing environmental pressures. Similarly to other catalysts, enzymes do not alter the equilibrium of the chemical reactions but enhance the rate of the reactions by lowering their activation energies (Cook and Cleland 2007). Reactions catalyzed by enzymes are generally precise and efficient, involving specific metabolic substrates transformed into predictable metabolic products using defined catalytic mechanisms. This ordered view of one enzyme -one mechanism -one product comes from seminal discoveries made by many investigators during the last century, focused for excellent practical reasons on the phylogenetically...

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Section: Genomic Variation As Raw Materials For Metabolic Innovationmentioning

confidence: 94%

The Remarkable Pliability and Promiscuity of Specialized Metabolism

Weng

Noel

2012

Cold Spring Harbor Symposia on Quantitative Biology

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“…Hardig et al 2000). Also, it has been found that these additional markers may unveil hybrid individuals that go undetected when using problematic DNA markers such as RAPD or AFLP (e.g., Kirk et al 2012). However, the main reason to study phenotypic and chromosomal traits in hybrids is that they may give insights of their ecological performance.…”

Section: Genetic Data Employed For Hybrid Recognition: Chromosome Nummentioning

confidence: 99%

Genetic, morphological, and chemical patterns of plant hybridization

López-Caamal

Tovar-Sánchez

2014

Rev. Chil. de Hist. Nat.

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Natural hybridization is a frequent phenomenon among vascular plants. Hybridization is considered an important evolutionary force since it may lead to (1) an increase of the intraspecific genetic diversity of the participating populations, (2) the creation of new species, (3) species extinction through genetic assimilation, and (4) the generation of highly invasive genotypes. Because of the importance of plant hybridization in evolution, it is of great importance to accurately identify hybrid individuals. In this review, we give a general historical background of the study of plant hybridization. Also, we review some of the tools employed for hybrid recognition and their pattern of expression in hybrid individuals (morphological, chemical, chromosome number, and DNA fingerprinting techniques). We emphasize that even when chromosome number, morphological characters, and chemical characters are of limited use for hybrid recognition in the absence of DNA fingerprinting techniques, their exploration may give insights of the ecological performance of hybrids. This is of special importance when hybridization leads to evolutionary novelty in the form of polyploidy, transgressive character expression, or the expression of new secondary metabolites not present in the parental species.

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“…Metabolomics tools have been used to evaluate the impact of the genotype and the environment on the quality of plant growth in the study of interpecific hybrids between Jacobaea aquatica and J. vulgaris (common weeds native to Northern Eurasia). An NMR-based metabolomics profiling approach was used to correlate the expression of high and low concentrations of particular compounds, including phenylpropanoids and sugars, with results of quantification of genetically controlled differences between major primary and secondary metabolites [81]. In melon (Cucumis melo L.), metabolomic and elemental profiling of fruit quality were found to be affected by genotype and environment [82].…”

Section: Plant Metabolomics and Applicationsmentioning

confidence: 99%

Abiotic Stress in Plants and Metabolic Responses

Fraire-Velázquez¹,

Balderas‐Hernández²

2013

Abiotic Stress - Plant Responses and Applications in Agriculture

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The vast metabolic diversity observed in plants is the direct result of continuous evolutionary processes. There are more than , known plant secondary metabolites, representing a vast reservoir of diverse functions. When the environment is adverse and plant growth is affected, metabolism is profoundly involved in signaling, physiological regulation, and defense responses. "t the same time, in feedback, abiotic stresses affect the biosynthesis, concentration, transport, and storage of primary and secondary metabolites. Metabolic adjustments in response to abiotic stressors involve fine adjustments in amino acid, carbohydrate, and amine metabolic pathways. Proper activation of early metabolic responses helps cells restore chemical and energetic imbalances imposed by the stress and is crucial to acclimation and survival. Time-series experiments have revealed that metabolic activities respond to stress more quickly than transcriptional activities do. In order to study and map all the simultaneous metabolic responses and, more importantly, to link these responses to a specific abiotic stress, integrative and comprehensive analyses are required. Metabolomics is the systematic approach through which qualitative and quantitative analysis of a large number of metabolites is increasing our knowledge of how complex metabolic networks interact and how they are dynamically modified under stress adaptation and tolerance processes. " vast amount of research has been done using metabolomic approaches to i characterize metabolic responses to abiotic stress, ii to discover novel genes and annotate gene function, and, iii more recently, to identify metabolic quantitative trait loci. The integration of the collected metabolic data concerning abiotic stress responses is helping in the identification of tolerance traits that may be transferable to cultivated crop species. In this review, the diverse metabolic responses identified in plants so far are discussed. We also include recent advances in the study of plant metabolomes and metabolic fluxes with a focus on abiotic stress-tolerance trait interactions.

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Transgressive segregation of primary and secondary metabolites in F2 hybrids between Jacobaea aquatica and J. vulgaris

Cited by 24 publications

References 30 publications

The Remarkable Pliability and Promiscuity of Specialized Metabolism

The Remarkable Pliability and Promiscuity of Specialized Metabolism

Genetic, morphological, and chemical patterns of plant hybridization

Abiotic Stress in Plants and Metabolic Responses

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