Transient abnormal lymphomyelopoiesis in a newborn with PTPN11 mutation associated Noonan syndrome

Issue Highlights—September 2022

“…Interestingly, the patients immunophenotyping findings, which are reported here, appear to recapitulate in part the prenatal generation of thymocytes, referred to as layered immune constitution (Davenport et al, 2020). (Abdelghani et al, 2022). A number of genetic mutations can result in Noonan syndrome, which may be inherited as an autosomal dominant condition or occur as a new mutation (Roberts et al, 2013).…”

“…Finally, the second Case Study is presented by Eman Abdelghani, Clifford Mueller, and Huifei Liu from the Ohio State University College of Medicine and Esoterix Pathology Practice Group. They describe an abnormal, transient lymphomyelopoiesis resembling a mixed phenotype acute leukemia in a newborn patient with Nooan syndrome (Abdelghani et al, 2022). A number of genetic mutations can result in Noonan syndrome, which may be inherited as an autosomal dominant condition or occur as a new mutation (Roberts et al, 2013).…”