Transient amantadine‐induced musical hallucinations in a patient with Parkinson's disease

Gondim, Francisco de Assis Aquino; Costa, Helida A.; Taunay, Tauily C.; Oliveira, Gisele R. de; Ferreira, Jamile Magalhães; Rola, Francisco H.

doi:10.1002/mds.22553

Cited by 13 publications

(14 citation statements)

References 6 publications

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“…They include benzodiazepines [lormetazepam (Ginsberg, 2003), temazepam (Fisman, 1991), lorazepam (Curtin and Remund, 2002), and triazolam (Nevins, 1991)], opioids [morphine (Davies and Quinn, 2005), tramadol (Keeley et al, 2000) and oxycodone (Moore, 2003)], tricyclic antidepressants [imipramine (Terao, 1995), clomipramine (Vallada and Gentil, 1991) and mirtazapine (Padala et al, 2010)], anticholinergic medication [biperiden (Gertz et al, 1996)], alcohol (Scott, 1975), an N-methyl-D-aspartate antagonist [amantadine (Gondim et al, 2010)], a dopamine agonist [bromocriptine (Kobayashi et al, 2004)], salicylates (Allen, 2008), dipyridamole(Tomar and Cheung, 2007), propranolol (Fernandez and Crowther, 1998), voriconazole (Agrawal and Sherman, 2004), pentoxifylline (Gilbert, 1993) and steroids (Kanemura et al, 2010). …”

Section: Resultsmentioning

confidence: 99%

Musical hallucinations: review of treatment effects

et al. 2015

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Background: Despite an increased scientific interest in musical hallucinations over the past 25 years, treatment protocols are still lacking. This may well be due to the fact that musical hallucinations have multiple causes, and that published cases are relatively rare.Objective: To review the effects of published treatment methods for musical hallucinations.Methods: A literature search yielded 175 articles discussing a total number of 516 cases, of which 147 articles discussed treatment in 276 individuals. We analyzed the treatment results in relation to the etiological factor considered responsible for the mediation of the musical hallucinations, i.e., idiopathic/hypoacusis, psychiatric disorder, brain lesion, and other pathology, epilepsy or intoxication/pharmacology.Results: Musical hallucinations can disappear without intervention. When hallucinations are bearable, patients can be reassured without any other treatment. However, in other patients musical hallucinations are so disturbing that treatment is indicated. Distinct etiological groups appear to respond differently to treatment. In the hypoacusis group, treating the hearing impairment can yield significant improvement and coping strategies (e.g., more acoustic stimulation) are frequently helpful. Pharmacological treatment methods can also be successful, with antidepressants being possibly more helpful than antiepileptics (which are still better than antipsychotics). The limited use of acetylcholinesterase inhibitors has looked promising. Musical hallucinations occurring as part of a psychiatric disorder tend to respond well to psychopharmacological treatments targeting the underlying disorder. Musical hallucinations experienced in the context of brain injuries and epilepsy tend to respond well to antiepileptics, but their natural course is often benign, irrespective of any pharmacological treatment. When intoxication/pharmacology is the main etiological factor, it is important to stop or switch the causative substance or medication.Conclusion: Treatments for musical hallucinations tend to yield favorable results when they target the main etiological factor of these phenomena. There is a need to establish the natural course of musical hallucinations, their response to non-pharmacological treatments, and their effects on the patient's quality of life. There is also a need to standardize the assessment of treatment responses, and document long-term follow up.

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Section: Resultsmentioning

confidence: 99%

Musical hallucinations: review of treatment effects

et al. 2015

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“…Multiple case reports describe the development of musical hallucinations after medication (e.g., salicylates, propranolol, voriconazole, steroids, tricyclic antidepressants, amantidine, and dipyridamole) administration [23][24][25][26][27][28][29][30]. Whiplash injury and abdominal pain have also been associated with these hallucinations [31,32].…”

Section: What Other Kinds Of Auditory Toxic Effects Have Been Reported?mentioning

confidence: 99%

Oxymorphone Insufflation Associated with Acute Sensorineural Hearing Loss: Case Files of the University of Massachusetts Medical Toxicology Fellowship

Boyle

Rosenbaum

2013

J. Med. Toxicol.

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“…Hallucinations, spontaneous aberrant perceptions, occur in a significant proportion of cases (Diederich et al, 2009). Hallucinations can be induced by medications such as anticholinergics (Celesia and Wanamaker, 1972), dopamine agonists (Baker et al, 2009) and a range of medications modulating diverse neurochemical pathways (Porteous and Ross, 1956;Lees et al, 1977;Gondim et al, 2010;Friedman et al, 2011;Wand, 2012). This presents challenges to determining the causes and nature of AH in PD and DLB.…”

Section: Introductionmentioning

confidence: 99%

Auditory and visual hallucination prevalence in Parkinson’s disease and dementia with Lewy bodies: a systematic review and meta-analysis

Eversfield¹,

Orton²

2018

Preprint

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Background: Non-motor features of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) contribute significantly to disease burden yet are less well understood than motor features. Auditory hallucinations (AH) are commonly associated with psychotic disorders, yet their contribution to PD and DLB is not well understood.Methods: We conducted a systematic review and random-effects model meta-analyses of studies reporting AH associated with PD or DLB. Prevalence of visual hallucinations (VH) in identified studies meeting eligibility criteria were included in meta-analyses, facilitating comparison with AH. Synthesis of qualitative descriptions of AH was performed. PubMed, Web of Science and Scopus databases were searched for primary journal articles, written in English, published from 1970 to 2017. Studies reporting AH prevalence in PD or DLB were screened using PRISMA methods. Results: Searches identified 4,542 unique studies for consideration, of which, 26 met inclusion criteria. AH pooled prevalence in PD was estimated to be 8.9% (95% CI=5.3-14.5), while in DLB was estimated to be 30.8% (±23.4-39.3). VH were more common, with an estimated pooled prevalence in PD of 28.2% (±19.1-39.5), while in DLB they were estimated to be 61.8% (±49.1-73.0). Meta-regression determined that the use of validated methodologies to identify hallucinations produced higher prevalence estimates.Conclusions: AH and VH present in a substantial proportion of PD and DLB cases, with VH reported more frequently in both conditions. Both AH and VH are more prevalent in DLB than PD. There is a need for standardised use of validated methods to detect and monitor hallucinations.

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Transient amantadine‐induced musical hallucinations in a patient with Parkinson's disease

Cited by 13 publications

References 6 publications

Musical hallucinations: review of treatment effects

Musical hallucinations: review of treatment effects

Oxymorphone Insufflation Associated with Acute Sensorineural Hearing Loss: Case Files of the University of Massachusetts Medical Toxicology Fellowship

Auditory and visual hallucination prevalence in Parkinson’s disease and dementia with Lewy bodies: a systematic review and meta-analysis

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