Transient Analgesia Evoked by Noxious Stimulus Offset

Grill, Joshua D.; Coghill, Robert C.

doi:10.1152/jn.00730.2001

Cited by 142 publications

(177 citation statements)

References 14 publications

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“…Offset analgesia is most likely an endogenous painmodulating mechanism [70] described as B[a] disproportionately large decrease in pain intensity following a relatively small decrease in noxious stimulus intensity^ [71]. Offset Fig.…”

Section: Offset Analgesiamentioning

confidence: 99%

Altered Central Sensitization and Pain Modulation in the CNS in Chronic Joint Pain

Arendt‐Nielsen

Skou

Nielsen

et al. 2015

Curr Osteoporos Rep

145

136

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Musculoskeletal pain disorders are the second largest contributor to global disability underlining the significance of effective treatments. However, treating chronic musculoskeletal pain, and chronic joint pain (osteoarthritis (OA)) in particular, is challenging as the underlying peripheral and central pain mechanisms are not fully understood, and safe and efficient analgesic drugs are not available. The pain associated with joint pain is highly individual, and features from radiological imaging have not demonstrated robust associations with the pain manifestations. In recent years, a variety of human quantitative pain assessment tools (quantitative sensory testing (QST)) have been developed providing new opportunities for profiling patients and reaching a greater understanding of the mechanisms involved in chronic joint pain. As joint pain is a complex interaction between many different pain mechanisms, available tools are important for patent profiling and providing the basic knowledge for development of new drugs and for developing pain management regimes.

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Section: Offset Analgesiamentioning

confidence: 99%

Altered Central Sensitization and Pain Modulation in the CNS in Chronic Joint Pain

Arendt‐Nielsen

Skou

Nielsen

et al. 2015

Curr Osteoporos Rep

145

136

View full text Add to dashboard Cite

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“…Thermal stimuli were delivered by a Peltier-based thermode (23mm × 23mm) in three 30s trials to the right forearm. For each trial, a three temperature stimulus train (e.g., 47°C [ (16). Once in contact with the skin, the thermode was ramped from a neutral temperature to the participant's testing temperature for 15 s (T1).…”

Section: Conditioned Pain Modulation (Cpm)-mentioning

confidence: 99%

Self-reported physical activity predicts pain inhibitory and facilitatory function

Naugle

Riley

2013

The Journal of Pain

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Considerable evidence suggests regular physical activity can reduce chronic pain symptoms. Dysfunction of endogenous facilitatory and inhibitory systems has been implicated in multiple chronic pain conditions. However, few studies have investigated the relationship between levels of physical activity and descending pain modulatory function.Purpose-This study's purpose was to determine whether self-reported levels of physical activity in healthy adults predicted 1) pain sensitivity to heat and cold stimuli, 2) pain facilitatory function as tested by temporal summation of pain (TS), and 3) pain inhibitory function as tested by conditioned pain modulation (CPM) and offset analgesia.Methods-Forty-eight healthy adults (age range 18-76) completed the International Physical Activity Questionnaire (IPAQ) and the following pain tests: heat pain thresholds (HPT), heat pain suprathresholds, cold pressor pain (CPP), temporal summation of heat pain, conditioned pain modulation, and offset analgesia. The IPAQ measured levels of walking, moderate, vigorous and total physical activity over the past seven days. Hierarchical linear regressions were conducted to determine the relationship between each pain test and self-reported levels of physical activity, while controlling for age, sex and psychological variables.Results-Self-reported total and vigorous physical activity predicted TS and CPM (p's <.05). Individuals who self-reported more vigorous and total physical activity exhibited reduced temporal summation of pain and greater CPM. The IPAQ measures did not predict any of the other pain measures.Conclusion-Thus, these results suggest that healthy older and younger adults who self-report greater levels of vigorous and total physical activity exhibit enhanced descending pain modulatory function. Improved descending pain modulation may be a mechanism through which exercise reduces or prevents chronic pain symptoms. KeywordsVigorous; Pain modulation; Temporal Summation; Conditioned Pain Modulation; ExerciseThe prevalence estimates of chronic pain among adults in the United States may be as high as 40%, affecting approximately 100 million adults (15). Pain increases physical disability (32), reduces quality of life, and is costly to both the individual experiencing pain and the Copyright © 2013 American College of Sports MedicineCorresponding Author: Kelly M. Naugle, College of Dentistry, University of Florida, 1329 SW 16 th Street, Rm 5180, Gainesville, FL 32608, Phone: 352-273-5975, Fax: 352-273-5985, knaugle@dental.ufl.edu. Conflict of InterestThere are not actual or potential conflicts of interest for any of the authors. The results of the present study do not constitute endorsement by ACSM. nation (15). Alarmingly, a recent study reported that the national cost of pain exceeds the cost of the nation's priority health conditions (e.g., cardiovascular disease, neoplasms, endocrine, nutritional and metabolic diseases), with costs ranging from $560 to $635 billion annually (15). Clearly, a need exists for effective meth...

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“…Moreover, several differential functions within each component of NAcc have been reported in animal studies (McFarland, Lapish, & Kalivas, 2003;Grill & Coghill, 2002;Zahm, 1999), albeit not in humans. Finally, disturbances at the level of NAcc have been implicated in drug abuse and schizophrenia, in addition to affective disorders (Kienast & Heinz, 2006;Totterdell, 2006).…”

Section: Introductionmentioning

confidence: 96%

Functional Connectivity and Coactivation of the Nucleus Accumbens: A Combined Functional Connectivity and Structure-Based Meta-analysis

Cauda

Cavanna

D’Agata

et al. 2011

Journal of Cognitive Neuroscience

193

144

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Abstract■ This article investigates the functional connectivity patterns of the nucleus accumbens (NAcc) in 18 healthy participants using a resting state functional connectivity (rsFC) protocol. Also, a meta-analytic connectivity modeling (MACM) was used to characterize patterns of functional coactivations involving NAcc: The results of a structure-based meta-analyses of 57 fMRI and PET studies were submitted to activation likelihood estimation analysis to estimate consistent activation patterns across the different imaging studies. The results of the combined rsFC and MACM analyses show that spontaneous activity in NAcc predicts activity in regions implicated in reward circuitries, including orbitomedial prefrontal cortex, globus pallidus, thalamus, midbrain, amygdala, and insula. This confirms the key role of NAcc in the mesocorticolimbic system, which integrates inputs from limbic and cortical regions. We also detected activity in brain regions having few or no direct anatomical connections with NAcc, such as sensorimotor cortex, cerebellum, medial and posterior parietal cortex, and medial/inferior temporal cortex, supporting the view that not all functional connections can be explained by anatomical connections but can also result from connections mediated by third areas. Our rsFC findings are in line with the results of the structure-based meta-analysis: MACM maps are superimposable with NAcc rsFC results, and the reward paradigm class is the one that most frequently generates activation in NAcc. Our results overlap considerably with recently proposed schemata of the main neuron systems in the limbic forebrain and in the anterior part of the limbic midbrain in rodents and nonhuman primates. ■

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Transient Analgesia Evoked by Noxious Stimulus Offset

Cited by 142 publications

References 14 publications

Altered Central Sensitization and Pain Modulation in the CNS in Chronic Joint Pain

Altered Central Sensitization and Pain Modulation in the CNS in Chronic Joint Pain

Self-reported physical activity predicts pain inhibitory and facilitatory function

Functional Connectivity and Coactivation of the Nucleus Accumbens: A Combined Functional Connectivity and Structure-Based Meta-analysis

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