Transient Angiolymphoid Hyperplasia and Kaposi's Sarcoma after Primary Infection with Human Herpesvirus 8 in a Patient with Human Immunodeficiency Virus Infection

Oksenhendler, Éric; Cazals–Hatem, Dominique; Schulz, Thomas F.; Barateau, Véronique; Grollet, L; Sheldon, Julie; Clauvel, Jean‐Pierre; Sigaux, François; Agbalika, F.

doi:10.1056/nejm199805283382204

Cited by 98 publications

(37 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1,2 Among these are primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD). 3,4 MCD is characterized by lymphadenopathy with angiofollicular hyperplasia and plasma cell infiltration.…”

Section: Introductionmentioning

confidence: 99%

High incidence of Kaposi sarcoma–associated herpesvirus–related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease

Oksenhendler

Boulanger

Galicier

et al. 2002

Blood

Self Cite

368

270

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

High incidence of Kaposi sarcoma–associated herpesvirus–related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease

Oksenhendler

Boulanger

Galicier

et al. 2002

Blood

Self Cite

368

270

View full text Add to dashboard Cite

“…Also in keeping with the idea that MCD may reflect active viral lytic replication in lymphoid tissue is the observation that MCD can also be a manifestation of a primary infection with KSHV in an HIV-infected individual [128] or in transplant recipients [133]. Clinically visible MCD is, however, a rare outcome of primary KSHV infection, in spite of about 10% of HIV-1-infected individuals that seroconvert to KSHV having detectable KSHV viraemia in their peripheral blood [57].…”

Section: The Role Of Kshv In Multicentric Castleman's Disease (Mcd)mentioning

confidence: 88%

“…Except for several studies reporting the frequent detection of KSHV DNA in MCD, there are no systematic epidemiological studies to quantify the risk of MCD in KSHV-infected individuals. However, several case reports have linked de novo infection with KSHV of transplant recipients or HIV-infected patients to the relatively rapid emergence of MCD [127,128,133].…”

Section: The Role Of Kshv In Multicentric Castleman's Disease (Mcd)mentioning

confidence: 99%

The pleiotropic effects of Kaposi's sarcoma herpesvirus

Schulz

2005

The Journal of Pathology

157

143

View full text Add to dashboard Cite

Kaposi's sarcoma herpesvirus (KSHV), or human herpesvirus 8 (HHV8), is an essential factor in the pathogenesis of Kaposi's sarcoma (KS), multicentric Castleman's disease (MCD), and primary effusion lymphoma (PEL). Case reports suggest an occasional involvement in bone marrow hypoplasia and haemophagocytic syndrome, but other disease associations are unconfirmed or controversial. KSHV-associated disease is of particular importance in immunosuppressed individuals, in particular in patients with HIV infection and transplant recipients. KSHV establishes a latent infection in the majority of infected cells in KS, MCD, and PEL, but lytic replication occurs in a small fraction of infected cells. Viral proteins expressed during both the latent and the lytic phase of the viral life cycle contribute to the pathogenesis of KSHV-associated diseases.

show abstract

“…A retrospective diagnosis of HHV-8 primary infection was reported: the patient presented fever, arthralgia and polyadenopathy, which may be mistaken for numerous viral primary infections [15].…”

Section: Human Herpesvirus-8mentioning

confidence: 99%

“…To evaluate its prevalence in epidemiological studies, HHV-8 infection is diagnosed by immunoglobulin (Ig)G-positive serology results [15]. The results of past studies were affected by the high variability of the available tests [21].…”

Section: Human Herpesvirus-8mentioning

confidence: 99%

Pulmonary manifestations of human herpesvirus-8 during HIV infection

et al. 2013

View full text Add to dashboard Cite

Human herpesvirus (HHV)-8 is an oncogenic gamma herpesvirus that was first described in 1994 in Kaposi sarcoma lesions. HHV-8 is involved in the pathophysiological features of multicentric Castleman's disease (MCD) and primary effusion lymphoma (PEL), both rare B-cell lymphoproliferative diseases. HHV-8-related tumours occur almost exclusively in immunocompromised patients, mostly those with HIV infection. Combined antiretroviral therapies have reduced the incidence of Kaposi sarcoma but not MCD and PEL.HHV-8-related diseases frequently exhibit pulmonary involvement, which may indicate the disease. Kaposi sarcoma in the lung is often asymptomatic but may require specific therapy. It mostly shows cutaneous or mucosal involvement. Patients with typical MCD present fever and lymphadenopathy associated with interstitial lung disease without opportunistic infection. Specific treatment may be urgent. PEL provokes a febrile, lymphocytic-exudative pleural effusion, without a pleural mass on computed tomography scan. Rapid diagnosis prevents unnecessary examinations and leads to specific, rapid treatment. Therapy is complex, combining antiretroviral therapy and chemotherapy. @ERSpublications HHV-8-related diseases frequently exhibit pulmonary involvement, which may indicate the disease

show abstract

Transient Angiolymphoid Hyperplasia and Kaposi's Sarcoma after Primary Infection with Human Herpesvirus 8 in a Patient with Human Immunodeficiency Virus Infection

Cited by 98 publications

References 22 publications

High incidence of Kaposi sarcoma–associated herpesvirus–related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease

High incidence of Kaposi sarcoma–associated herpesvirus–related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease

The pleiotropic effects of Kaposi's sarcoma herpesvirus

Pulmonary manifestations of human herpesvirus-8 during HIV infection

Contact Info

Product

Resources

About