characteristic electrocardiogram (ECG) consisting of right bundle branch block and coved (or saddleback) type ST-segment elevation in the precordial leads (Brugada-type ST shift) has been associated with aborted cardiac sudden death without structural heart diseases. 1 Because of the increased awareness of this ECG evidence, the Brugada-type ST shift is being discovered incidentally in more and more asymptomatic subjects; we previously reported a rate of 0.14% in the general Japanese population. 2 ECG changes consistent with myocardial ischemia have been associated with inflammatory conditions, such as acute cholecystitis, 3 pancreatitis 4 and myocarditis, 5 usually in the form of T-wave inversion, ST-segment depression, but rarely ST-segment elevation regardless of the presence of coronary artery disease. However, Brugada-type ST shift has not been reported in such conditions. We describe a patient with asymptomatic Brugada-type ST shift mimicked by acute cholecystitis.
Case ReportA 69-year-old woman was referred to hospital because of abdominal discomfort and fever. She did not have a history of syncope or a family history of sudden cardiac death. She had previously been diagnosed with psychotic depression and treated with low-dose antidepressants, including a tetracyclic antidepressant (mianserin, 30 mg/day), a tricyclic antidepressant (amoxapine, 10 mg/day), and a serotoninnoradrenalin reuptake inhibitor (trazodone, 50 mg/day). The patient continued to take these antidepressants after admission. Her blood pressure was 116/70 mmHg, pulse rate was 84 beats/min and regular, and temperature was 38.7°C. There were no abnormalities in heart sounds or respiratory sounds. Abdominal examination revealed mild tenderness without rebound in the upper abdomen. The results of hematological tests on admission showed elevated white blood cell count (11,400 / l), C-reactive protein (15.1 mg/dl), aspartate aminotransferase (197 IU/L), alanine aminotransferase (173 IU/L), alkaline phosphatase (334 IU/L), and -glutamyl transpeptidase (64 IU/L). Serum bilirubin, amylase, electrolytes, and thyroid function were normal. The patient showed a negative reaction to a troponin T rapid test on admission. Serial changes of creatine kinase were normal with the MB fraction less than 5%. Chest X-ray revealed no pulmonary edema or cardiac enlargement. Abdominal ultrasound and computed tomography showed the appearance of gallbladder stones in a thickened gallbladder with pericholecystic fluid but without ductal dilation. These findings led to the diagnosis of acute cholecystitis.The 12-lead ECG on admission showed sinus rhythm with normal PQ, QT, and corrected QT intervals, a heart rate of 82 beats/min, incomplete right bundle branch block, and ST-segment elevation in V1 and V2 (Fig 1A). The ECG abnormality was compatible with a Brugada-type ST shift consisting of a coved-type elevation in V1 and a saddleback type in V2. The patient was treated with intravenous drips and antibiotic therapy (cefotiam, CTM). During the 7 days after hospitalizat...