Silicon carbide(SiC) neutron detectors can be applied to extreme environments with high temperature and strong radiation. The total noise factor is most significantly influenced by the noise factor of the first stage in a cascade amplifier. Hence, the preamplifier must exhibit exceptional noise performance. The readout circuit is inevitably exposed to the influence of radiation, which may result in temporary or even permanent failure of electronic systems. The connection method between the SiC neutron detector and the readout circuit is typically DC-coupled. When the sensor is working, the leakage current generated by the sensor will enter the input end of the CSA and change the baseline position of the CSA. In this paper, a low-noise CSA with leakage current compensation circuit(LCC) is presented. The circuit’s voltage-to-charge amplification is 2.98mV/fC, and the error due to nonlinearity is below 0.01%. Without considering the input parasitic capacitance, ENC is 43.12e-. In addition, the circuit also has good radiation resistance and leakage current compensation function. It is implemented and simulated in the DB Hitek 0.18μm CMOS process model.