Transient developmental exposure to tributyltin reduces optomotor responses in larval zebrafish (Danio rerio)

Bernardo, Rachel C.; Connaughton, Victoria P.

doi:10.1016/j.ntt.2021.107055

Cited by 11 publications

(4 citation statements)

References 83 publications

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“…( 59 ), reporting no effect of aromatase inhibition on larval zebrafish development. However, our study contrasts those demonstrating chemical inhibition of both aromatases affect one or multiple of these morphometrics ( 36 , 56 , 57 , 60 , 61 ). It is possible that significant differences in these morphometrics might emerge during later development after 2 dpf.…”

Section: Discussioncontrasting

confidence: 93%

“…Thus, total aromatase activity of the father contributes to offspring survival. This idea is supported by previous studies reporting increased mortality in larval zebrafish during acute chemical aromatase inhibition ( 36 , 54 – 57 ). Moreover, both cyp19a1 transcripts are expressed during the first 48 h post-fertilization in zebrafish embryos, which suggests a role in early development and survival ( 58 ).…”

Section: Discussionsupporting

confidence: 81%

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Mutation of brain aromatase disrupts spawning behavior and reproductive health in female zebrafish

Shaw,

Therrien,

et al. 2023

Front. Endocrinol.

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Aromatase (Cyp19a1) is the steroidogenic enzyme that converts androgens into bioactive estrogens, and hence is in a pivotal position to mediate reproduction and sexual behavior. In teleosts, there are two aromatase paralogs: cyp19a1a that is highly expressed in granulosa and Leydig cells in the gonads with critical function in sexual differentiation of the ovary, and cyp19a1b that is highly expressed in radial glial cells in the brain with unknown roles in reproduction. Cyp19a1-/- mutant zebrafish lines were used to investigate the importance of the cyp19a1 paralogs for spawning behavior and offspring survival and early development. Mutation of cyp19a1b was found to increase the latency to the first oviposition in females. Mutation of cyp19a1b in females also increased the number of eggs spawned; however, significantly more progeny died during early development resulting in no net increase in female fecundity. This finding suggests a higher metabolic cost of reproduction in cyp19a1b-/- mutant females. In males, the combined mutation of both cyp19a1 paralogs resulted in significantly lower progeny survival rates, indicating a critical function of cyp19a1 during early larval development. These data establish the specific importance of cyp19a1b for female spawning behavior and the importance of the cyp19a1 paralogs for early larval survival.

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Section: Discussioncontrasting

confidence: 93%

Section: Discussionsupporting

confidence: 81%

Mutation of brain aromatase disrupts spawning behavior and reproductive health in female zebrafish

Shaw,

Therrien,

et al. 2023

Front. Endocrinol.

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“…Degeneration and abnormal ordering of retinal layers has also been observed in larvae exposed to TBT for 10 days ( Fent and Meier, 1992 ). Additionally, transient 24-h exposure to TBT during development alters visually guided optomotor responses (OMRs) measured 1-week after removal from treatment ( Bernardo and Connaughton, 2022 ). Effects were age-dependent, with reduced OMRs occurring if TBT exposure occurred at 72 hpf or 7 dpf; reduced eye diameters were also observed when exposure occurred at 7 dpf.…”

Section: Introductionmentioning

confidence: 99%

The Role of Estrogen and Thyroid Hormones in Zebrafish Visual System Function

et al. 2022

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Visual system development is a highly complex process involving coordination of environmental cues, cell pathways, and integration of functional circuits. Consequently, a change to any step, due to a mutation or chemical exposure, can lead to deleterious consequences. One class of chemicals known to have both overt and subtle effects on the visual system is endocrine disrupting compounds (EDCs). EDCs are environmental contaminants which alter hormonal signaling by either preventing compound synthesis or binding to postsynaptic receptors. Interestingly, recent work has identified neuronal and sensory systems, particularly vision, as targets for EDCs. In particular, estrogenic and thyroidogenic signaling have been identified as critical modulators of proper visual system development and function. Here, we summarize and review this work, from our lab and others, focusing on behavioral, physiological, and molecular data collected in zebrafish. We also discuss different exposure regimes used, including long-lasting effects of developmental exposure. Overall, zebrafish are a model of choice to examine the impact of EDCs and other compounds targeting estrogen and thyroid signaling and the consequences of exposure in visual system development and function.

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“…Measurements of edge preference (thigmotaxis) as an indication of anxiety (Richendrfer et al, 2012;Schnoor et al, 2012) and differences in swimming behaviors/activity (Richendrfer et al, 2012) can be used to quantify the effects of sublethal chemical concentrations (Little & Finger, 1990). More recent studies have reported changes in larval behaviors in response to exposure to heavy metals (LeFauve & Connaughton, 2017), alcohol (Clayman et al, 2017), and endocrine disruptors (Bernardo & Connaughton, 2022;Crowley-Perry et al, 2021;Gould et al, 2017;Gould et al, 2019). (DOEE, 2019;McGee et al, 2009;Murray et al, 2015;Velinsky et al, 2011;Wade et al, 1994;Wilson, 2019).…”

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confidence: 99%

Developmental effects of siloxane exposure in zebrafish: A comparison study using laboratory‐mixed and environmental water samples

Jessup

Wiegand

Delbridge‐Perry

et al. 2022

J of Applied Toxicology

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Siloxanes are used in personal care, biomedical, and industrial products. Their worldwide use and persistence in the environment cause consistent exposure for both humans and aquatic animals. Two siloxane congeners, decamethylcyclopentasiloxane (D5; CAS 541-02-6) and octamethylcyclotetrasiloxane (D4; CAS 556-67-2), are among the most prevalent, with measurable levels in air, sediment, water, and biological samples. However, few studies have examined the impact of developmental (embryo/larva) exposure. To address this gap, we performed parallel experiments using wildtype zebrafish (Danio rerio). One set of experiments used laboratory-mixed individual solutions containing either D4, D5, or 2,4,6,8-tetramethylcyclotetrasiloxane (D 4 H ; CAS 2370-88-9); the other used environmental water samples containing a mixture of siloxanes, including D4 and D5. These samples were collected from Bladensburg Waterfront Park (BWP) a site along the Anacostia River, Washington, DC. In both experiments, zebrafish (24-48 h postfertilization, hpf) were exposed until 7 or 14 days (d)pf. Chronic exposure to D4, D5, orBWP water until 7 dpf caused stress-like behaviors and reduced swim velocities; anatomical differences were noted only in BWP-exposed larvae. At 14 dpf, BWP-treated larvae still showed slower swimming velocities and increased immobility; anatomical differences were no longer evident and thigmotactic behavior was reduced. D4 and D5-exposed larvae did not survive after 10 dpf. Larvae exposed to D 4 H showed no decreases in behavior or growth at either age. These results suggest early developmental sensitivity to siloxane exposure and point to the need to consider embryonic/ larval endpoints when assessing aquatic contaminants.

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Transient developmental exposure to tributyltin reduces optomotor responses in larval zebrafish (Danio rerio)

Cited by 11 publications

References 83 publications

Mutation of brain aromatase disrupts spawning behavior and reproductive health in female zebrafish

Mutation of brain aromatase disrupts spawning behavior and reproductive health in female zebrafish

The Role of Estrogen and Thyroid Hormones in Zebrafish Visual System Function

Developmental effects of siloxane exposure in zebrafish: A comparison study using laboratory‐mixed and environmental water samples

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