Transient diabetes insipidus in a very‐low‐birthweight preterm infant with intraventricular haemorrhage

Molnár, Zoltán; Sotiridou, Ellada; Dixon, Hilary; Ogilvy-Stuart, Amanda

doi:10.1111/j.1651-2227.2012.02756.x

Cited by 9 publications

(5 citation statements)

References 5 publications

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“…A previous case report on a premature infant with CDI secondary to intracranial hemorrhage had a transient course. 14 That case may have been due to cerebral edema. 15 CDI is not necessarily transient in nature, but its duration depends on the location of the damage in the hypothalamic-pituitary region.…”

Section: Discussionmentioning

confidence: 99%

Central diabetes insipidus: alert for dehydration in very low birth weight infants during the neonatal period. A case report

et al. 2014

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CONTEXT: Central diabetes insipidus (CDI) is a rare cause of hypernatremia during the neonatal period.The diagnosis is particularly difficult in very low birth weight (VLBW) newborns. CASE REPORT: We report on a preterm newborn who presented CDI soon after birth. On the third day of life, signs of dehydration were present despite normal fluid supply. The diuresis rate was 4.4 ml/kg/h. Although the fluid supply was then increased, the dehydration continued, with hypernatremia, normal glycemia, diuresis of 7.4 ml/kg/h and urine density of 1005 mOsmol/l. Thus, a diagnostic hypothesis of diabetes insipidus was raised. A test with a nasal vasopressin analogue (dDAVP) was performed and CDI was confirmed. Reduction of the fluid supply became possible through appropriate treatment. CONCLUSION:The diagnosis of CDI is rarely made during the neonatal period, especially in VLBW newborns, because of the difficulty in detecting elevated diuresis. Persistent hypernatremia, usually accompanied by hyperthermia despite abundant fluid supply, weight loss and low urine osmolality are important signs of alert. RESUMO CONTEXTO:Diabete insípido central (DIC) é uma rara causa de hipernatremia durante o período neonatal. O diagnóstico é difícil, particularmente em recém-nascidos (RN) de muito baixo peso (RNMBP). RELATO DE CASO: Relatamos um RN que apresentou DIC logo após o nascimento. No terceiro dia de vida, apresentava sinais de desidratação, embora estivesse recebendo aporte adequado de líquidos. A diurese aferida era de 4,4 ml/kg/h. Apesar do aumento do aporte hídrico, manteve-se desidratado, com hipernatremia, valores normais de glicemia e diurese de 7,4 ml/kg/h com densidade urinária de 1005 mOsmol/l. Desta forma, a hipótese diagnóstica de diabete insípido foi considerada. O teste com análogo da vasopressina (dDAVP) foi realizado e DIC foi confirmado. A redução do aporte de líquidos foi possível com o tratamento adequado. CONCLUSÃO: O diagnóstico de DIC raramente é realizado durante o período neonatal, particularmente em RNMBP, devido à dificuldade em detectar diurese aumentada. Hipernatremia persistente, geralmente acompanhada de hipertermia, apesar do abundante aporte de água, perda de peso e osmolaridade urinaria baixa, são importantes sinais de alerta.

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Section: Discussionmentioning

confidence: 99%

Central diabetes insipidus: alert for dehydration in very low birth weight infants during the neonatal period. A case report

et al. 2014

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“…In our patient, intracranial hemorrhage, neonatal sepsis and meningitis were excluded, and CDI was accepted as secondary to HPE. Looking at the relationship between CDI and other endocrinopathies, no additional endocrinopathy was reported in some cases (9,15), while anterior pituitary insufficiency accompanied HPE in other cases (8). In our patient, thyroid function tests (TSH, fT 4 ) and blood cortisol levels were normal excluding additional endocrinopathies.…”

Section: Discussionmentioning

confidence: 45%

Early-Onset Central Diabetes Insipidus in a Newborn With Holoprosencephaly

Aslan¹,

Ince²,

Çoban³

2021

jmed

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Holoprosencephaly is a complex brain malformation caused by the inability of the prosencephalon to divide to form the cerebral hemispheres. Central diabetes insipidus (CDI), as a result of a defect in vasopressin release, may be seen due to the abnormal hypothalamic infundibular region. CDI developing secondary to holoprosencephaly in the early neonatal period has rarely been reported in the literature. A case of early-onset CDI with holoprosencephaly and 13q deletion is presented.

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“…The consequences include serious conditions contributing to high morbidity and mortality of preterm neonates. Such conditions include impairment of the synthesis of proteins in which arginine is an essential building blocks (such as histones) hyperammonemia necrotizing enterocolitis, respiratory distress syndrome, and intraventricular hemorrhage . In some cases, such as hyperammonemia, these conditions might be corrected with arginine and citrulline administration but in other conditions may not be corrected.…”

Section: Discussionmentioning

confidence: 99%

“…Such conditions include impairment of the synthesis of proteins in which arginine is an essential building blocks (such as histones) hyperammonemia 21,33,34 necrotizing enterocolitis, 8-10 respiratory distress syndrome, 35,36 and intraventricular hemorrhage. 37 In some cases, such as hyperammonemia, these conditions might be corrected with arginine and citrulline administration but in other conditions may not be corrected. However, the fact that most of the enzymes are expressed in preterm neonates 29 and arginine and citrulline supplements have not been proven to be toxic, it is advisable to provide such supplements to preterm neonates.…”

Section: Discussionmentioning

confidence: 99%

Correlation between plasma levels of arginine and citrulline in preterm and full‐term neonates: Therapeutical implications

Contreras

Gallardo

Betancourt

et al. 2017

Clinical Laboratory Analysis

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Transient diabetes insipidus in a very‐low‐birthweight preterm infant with intraventricular haemorrhage

Cited by 9 publications

References 5 publications

Central diabetes insipidus: alert for dehydration in very low birth weight infants during the neonatal period. A case report

Central diabetes insipidus: alert for dehydration in very low birth weight infants during the neonatal period. A case report

Early-Onset Central Diabetes Insipidus in a Newborn With Holoprosencephaly

Correlation between plasma levels of arginine and citrulline in preterm and full‐term neonates: Therapeutical implications

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