Transient Directional Disorientation as a Manifestation of Cerebral Ischemia

Ino, Tadashi; Usami, Hideo; Tokumoto, Kazuki; Kimura, Tōru; Ozawa, Kyoko; Nakamura, Shotaro

doi:10.1159/000127979

Cited by 4 publications

(2 citation statements)

References 34 publications

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“…This view would be consistent with the type of deficit often observed in humans and animals with parietal damage – namely topographical disorientation. In the human version of this disorder, patients can typically recognize landmarks, but have a poor understanding of their spatial configuration with one another (Brain, 1941; De Renzi, 1982; Hublet & Demeurisse, 1992; Ino, Usami, Tokumoto, Kimura, Ozawa, & Nakamura, 2008). The deficits are readily apparent when they are asked to draw sketch maps representing the spatial relationships of objects.…”

Section: Parietal Cortex and The Cognitive Mapmentioning

confidence: 99%

Where am I and how will I get there from here? A role for posterior parietal cortex in the integration of spatial information and route planning

Calton

Taube

2009

Neurobiology of Learning and Memory

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The ability of an organism to accurately navigate from one place to another requires integration of multiple spatial constructs, including the determination of one's position and direction in space relative to allocentric landmarks, movement velocity, and the perceived location of the goal of the movement. In this review we propose that while limbic areas are important for the sense of spatial orientation, the posterior parietal cortex is responsible for relating this sense with the location of a navigational goal and in formulating a plan to attain it. Hence, the posterior parietal cortex is important for the computation of the correct trajectory or route to be followed while navigating. Prefrontal and motor areas are subsequently responsible for executing the planned movement. Using this theory, we are able to bridge the gap between the rodent and primate literatures by suggesting that the allocentric role of the rodent PPC is largely analogous to the egocentric role typically emphasized in primates, that is, the integration of spatial orientation with potential goals in the planning of goal-directed movements.This review examines the role the posterior parietal cortex (PPC) plays in spatial orientation and navigation. The successful act of navigation likely requires the integration of a number of different spatial constructs, including location and directional heading, the perception of linear and angular movement, the updating of spatial orientation after movement using idiothetic and landmark cues, and finding one's way along a route -often referred to as wayfinding. We argue that one role of the PPC in this behavior is to integrate the organism's perceived spatial orientation (i.e., the perception of current location and directional heading relative to the immediate surrounding environment) with the overall spatial view of the world (i.e., the spatial relationships of landmarks and goals with one another) in order to formulate an accurate route or trajectory to a goal. To expand on this concept further, consider the process of memory. It is often described as consisting of three major processes: 1) encoding, 2) consolidation, and 3) retrieval. A deficit in any one of these three functions will result in impaired performance on a memory task. Similarly, navigation can be thought of as composed of three processes: 1) spatial orientation, 2) manipulation of spatial representations to enable the computation of a planned route, and 3) execution of the plan. Like memory, a deficit in any one of these processes would result in poor output -in this case inaccurate navigation. In this review we contend that navigational deficits seen after damage to the PPC are largely due to an inability to integrate spatial orientation with the spatial position of the final goal and in formulating a plan to attain

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Section: Parietal Cortex and The Cognitive Mapmentioning

confidence: 99%

Where am I and how will I get there from here? A role for posterior parietal cortex in the integration of spatial information and route planning

Calton

Taube

2009

Neurobiology of Learning and Memory

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“…Widespread microstructural damage among the splenium and body of CC, CST, and SLF is only associated with total TUG duration in patients with MS. The splenium of CC connects the bilateral parietal, temporal, and occipital lobes (Hofer & Frahm, 2006 ) affecting multisensory integration and directional orientation (Ino et al, 2008 ), whereas the body of CC connects the bilateral frontal lobes (Hofer & Frahm, 2006 ) affecting feedforward postural motor learning (Peterson et al, 2017 ). Patients with MS who exhibit poorer integrity of the CC experience more difficulty in improving dynamic balance control during repeated balance training (Peterson et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Turning and multitask gait unmask gait disturbance in mild‐to‐moderate multiple sclerosis: Underlying specific cortical thinning and connecting fibers damage

Chen

Hattori

Tomisato

et al. 2022

Human Brain Mapping

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Multiple sclerosis (MS) causes gait and cognitive impairments that are partially normalized by compensatory mechanisms. We aimed to identify the gait tasks that unmask gait disturbance and the underlying neural correlates in MS. We included 25 patients with MS (Expanded Disability Status Scale score: median 2.0, interquartile range 1.0–2.5) and 19 healthy controls. Fast‐paced gait examinations with inertial measurement units were conducted, including straight or circular walking with or without cognitive/motor tasks, and the timed up and go test (TUG). Receiver operating characteristic curve analysis was performed to distinguish both groups by the gait parameters. The correlation between gait parameters and cortical thickness or fractional anisotropy values was examined by using three‐dimensional T1‐weighted imaging and diffusion tensor imaging, respectively (corrected p < .05). Total TUG duration (>6.0 s, sensitivity 88.0%, specificity 84.2%) and stride velocity during cognitive dual‐task circular walking (<1.12 m/s, 84.0%, 84.2%) had the highest discriminative power of the two groups. Deterioration of these gait parameters was correlated with thinner cortical thickness in regional areas, including the left precuneus and left temporoparietal junction, overlapped with parts of the default mode network, ventral attention network, and frontoparietal network. Total TUG duration was negatively correlated with fractional anisotropy values in the deep cerebral white matter areas. Turning and multitask gait may be optimal to unveil partially compensated gait disturbance in patients with mild‐to‐moderate MS through dynamic balance control and multitask processing, based on the structural damage in functional networks.

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Origins of Spatial Abilities

Ardila

2017

Historical Development of Human Cognition

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Transient Directional Disorientation as a Manifestation of Cerebral Ischemia

Cited by 4 publications

References 34 publications

Where am I and how will I get there from here? A role for posterior parietal cortex in the integration of spatial information and route planning

Where am I and how will I get there from here? A role for posterior parietal cortex in the integration of spatial information and route planning

Turning and multitask gait unmask gait disturbance in mild‐to‐moderate multiple sclerosis: Underlying specific cortical thinning and connecting fibers damage

Origins of Spatial Abilities

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