Transient elastography can be integrated into routine clinical practice for the evaluation of portal hypertension?

Kim, Seung Up

doi:10.3350/cmh.2017.0101

Cited by 3 publications

(3 citation statements)

References 28 publications

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“…The performance of Baveno VI criteria was similar regardless of liver disease aetiology (HBV, HCV, alcohol and NAFLD). Serum platelet count and LSM strongly correlate with fibrosis stage and portal hypertension . LSM has proven accuracy for discriminating patients with and without clinically significant portal hypertension, with a mean area under the receiver operating curve of 0.93 in a meta‐analysis .…”

Section: Discussionmentioning

confidence: 98%

Validation of the Baveno VI and the expanded Baveno VI criteria to identify patients who could avoid screening endoscopy

Bae

Sinn

Kang

et al. 2018

Liver International

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Section: Discussionmentioning

confidence: 98%

Validation of the Baveno VI and the expanded Baveno VI criteria to identify patients who could avoid screening endoscopy

Bae

Sinn

Kang

et al. 2018

Liver International

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“…[9][10][11][12][13][14][15] However, TE is not sufficiently accurate to replace HVPG due to its insufficient sensitivity and specificity. 16 Furthermore, TE has limitations for clinical application because of the wide range of cutoff values (range: 13.9-21.5 kPa) and variability in performance among studies (area under the receiver operating characteristic curve [AUROC] 0.76-0.85). 10,17,18 Recently, Ryu et al 19 evaluated the correlation between LS, LS to platelet ratio (LPR), LS-spleen diameter-to-platelet ratio score (LSPS), and HVPG according to the etiology of cirrhosis (alcoholic cirrhosis vs. viral cirrhosis).…”

mentioning

confidence: 99%

“…Recently, accumulating evidence has suggested that liver stiffness (LS) assessed using transient elastography (TE) can adequately reflect the findings of HVPG, indicating that it is a useful modality for evaluating PH and the resultant cirrhotic complications [ 9 - 15 ]. However, TE is not sufficiently accurate to replace HVPG due to its insufficient sensitivity and specificity [ 16 ]. Furthermore, TE has limitations for clinical application because of the wide range of cutoff values (range, 13.9–21.5 kPa) and variability in performance among studies (area under the receiver operating characteristic curve, 0.76–0.85) [ 10 , 17 , 18 ].…”

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confidence: 99%

The cutoff of transient elastography for the evaluation of portal hypertension should be different according to the etiology?

Kim

2021

Clin Mol Hepatol

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Fibrosis-4, aspartate transaminase-to-platelet ratio index, and gamma-glutamyl transpeptidase-to-platelet ratio for risk assessment of hepatocellular carcinoma in chronic hepatitis B patients: comparison with liver biopsy

Kim

Lee

Chon

et al. 2020

European Journal of Gastroenterology &Amp; Hepatology

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Background and aims: It is well known that hepatocellular carcinoma (HCC) develops as a consequence of hepatic fibrosis progression. Thus, early identification of advanced liver fibrosis is very important. This study evaluated the prognostic value of FIB-4, the aspartate transaminase to-platelet ratio index (APRI), and the gamma-glutamyl transpeptidase-toplatelet ratio (GPR) for predicting HCC development using histological fibrosis stage as a reference in Asian chronic hepatitis B (CHB) patients. Methods: A total of 444 CHB patients who underwent liver biopsy and serological tests for determining noninvasive serum fibrosis markers were enrolled. All patients were followed to monitor HCC development. Results: The histological fibrosis stage showed best performance in predicting HCC development at 5 (area under the receiver operating characteristic curve [AUROC] = 0.783) and 7 years (AUROC = 0.766), followed by FIB-4 (AUROC = 0.753 at 5 years, 0.698 at 7 years), APRI (AUROC = 0.658 at 5 years, 0.572 at 7 years), and GPR (AUROC = 0.638 at 5 years, 0.603 at 7 years). When we classified risk groups according to the histological fibrosis stage (F4 vs. F0-3) and FIB-4 (FIB-4 ≥ 3.25 vs. FIB-4 < 3.25), patients in the high-risk group were found to have a significantly higher probability of developing HCC than those in the low-risk group (P=0.005 and 0.022, respectively, log-rank test). Conclusion: Our study demonstrated that FIB-4 is useful for the noninvasive prediction of HCC development, while APRI and GPR were less useful.

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Transient elastography can be integrated into routine clinical practice for the evaluation of portal hypertension?

Cited by 3 publications

References 28 publications

Validation of the Baveno VI and the expanded Baveno VI criteria to identify patients who could avoid screening endoscopy

Validation of the Baveno VI and the expanded Baveno VI criteria to identify patients who could avoid screening endoscopy

The cutoff of transient elastography for the evaluation of portal hypertension should be different according to the etiology?

Fibrosis-4, aspartate transaminase-to-platelet ratio index, and gamma-glutamyl transpeptidase-to-platelet ratio for risk assessment of hepatocellular carcinoma in chronic hepatitis B patients: comparison with liver biopsy

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